Gallium-67 imaging in a patient with paracoccidioidomycosis: a case report

Teixeira, Ana Beatriz Marinho de Jesus; Etchebehere, Elba; Lima, Mariana; Santos, Allan de Oliveira; Pires, Bruno Morandi; Valença, José Telmo; Ramos, Celso Darío; Camargo, Edwaldo E.

doi:10.1590/s0036-46652000000300011

Cited by 4 publications

(7 citation statements)

References 7 publications

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“…Therefore, imaging methods are important to the overall diagnosis of PCM involvement and evaluation of its evolution for early diagnoses of recurrences. 19,21,32,36,39,40,44,[51][52][53][54][55] The differential diagnosis of PCM mainly consists of tuberculosis and lymphoma and other deep mycoses. Lymphomegaly in tuberculosis and PCM may have central necrosis and calcification.…”

Section: Discussionmentioning

confidence: 99%

The contribution of ultrasonography and computed tomography in the evaluation of abdominal involvement in paracoccidioidomycosis

Paula¹,

Pedroso²,

Ferreira³

2014

Revista Médica De Minas Gerais

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Introduction: paracoccidioidomycosis (PCM) is a polymorphic systemic granulomatous inflammatory disease determined by Paracoccidioides brasiliensis, one of the 10 leading causes of morbidity and mortality among the parasitic diseases endemic in Brazil. Objective: To identify the following aspects of PCM by ultrasound (US) and computed tomography (CT): abdominal changes, intensity and characteristics of the observed images, frequency of changes depending on clinical presentation, differences from other nosological entities. Patients and methods: This was a retrospective, observational, cross-sectional study carried out with 35 patients with PCM treated at the Hospital das Clinicas (HC) at the Universidade Federal de Minas Gerais (UFMG). Patients with tuberculosis, bronchial asthma, generalized chronic obstructive pulmonary disease, or in contact with silica or mines, as well as those with granulomatous diseases at any point in their current or past clinical history and detected through serology, anatomopathology or microbiological exams were excluded. Collected data were transcribed into SPSS for Windows ® for statistical analysis. The studywas approved by the UFMG Ethics Committee (082/00). Results and conclusion: CT and U.S. showed involvement of abdominal organs in all forms of PCM, including lymphadenopathy (40%), hepatomegaly (37%), splenomegaly (37%) and adrenal involvement (17%). Gallbladder and retroperitoneal musculature involvement were also observed, along with ascites and pleural effusion. Lymph node calcification, adrenal involvement and ascites constituted evidence of high probability of PCM even though these findings are not enough to differentiate PCM from tuberculosis. Chronic and sequelae forms, abdominal involvement is more frequent than indicated by the clinical manifestations.

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Section: Discussionmentioning

confidence: 99%

The contribution of ultrasonography and computed tomography in the evaluation of abdominal involvement in paracoccidioidomycosis

Paula¹,

Pedroso²,

Ferreira³

2014

Revista Médica De Minas Gerais

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“…The detection of antibodies against antigens from Paracoccidioidis or the existence of these antigens in body fluids constitute indirect diagnosis criterion for PCM. [10][11][12][13][14][15][16][17][18][19][20][21] for which appropriate therapy can contribute to avoid premature death and prevent serious sequelae. [1][2][3] It is important to consider on the initial diagnostic evaluation, in addition to the general state of the patient, the organs and systems most often affected, observing the clinical forms of the disease: acutesubacute and chronic.…”

Section: Immunological Testsmentioning

confidence: 99%

“…The sputum, as in tuberculosis, must be examined through the daily collection of samples, in three consecutive days. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] The anatomopathological study of tissue fragments also allows the direct examination in histopathologic preparations through staining with hematoxylin-eosin or with the use of special dyes such as Gomori -Grocot or Schiff periodic acid (Graph 1). The open air lung biopsy should be considered when the diagnosis is impossible via other methods.…”

Section: Direct Examinationmentioning

confidence: 99%

“…7,8,[26][27][28][29] Obtaining material for histological analysis can be difficult and is not recommended, as in central nervous or pulmonary isolated involvement, which requires invasive procedures such as craniotomy and thoracotomy, which are often unavailable in many PCM endemic areas, in addition to their high costs. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]…”

Section: Introductionmentioning

confidence: 99%

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Paracoccidioidomycosis disease (Lutz-Splendore-Almeida disease): Additional workup, differential diagnosis, cure control

Vasconcellos¹,

Ambrósio

Cristiane³

et al. 2014

Revista Médica De Minas Gerais

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The diagnosis of paracoccidioidomycosis requires epidemiological data to be available and for the presence of some more typical clinical manifestations.It requires complementary investigation with interventional methods, differential diagnosis of pathologies of great importance such as tuberculosis and lymphomas, and cure control. This update discusses the advances in these various areas, which include complementary investigation, differential diagnosis and cure control, pointing to development prospects that may help better define the best approach to this disease.

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“…A l t h o u g h i m a g i n g m e t h o d s s u c h a s high resolution computed tomography or pulmonary scintilography provide more detailed information, conventional chest radiography is still a valuable tool in evaluating PCM lung involvement, especially in countries where costs of more sophisticated imaging methods may be prohibiting [3][4][5][6][7] . Chest X-ray is frequently abnormal in patients with PCM and shows non-specific lung changes.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary paracoccidoidomycosis: radiology and clinical-epidemiological evaluation

Freitas

Prado

Prado³

et al. 2010

Rev. Soc. Bras. Med. Trop.

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Introduction:The purpose of this study was to compare respiratory signs and symptoms between patients with and without chest X-ray abnormalities in order to establish the meaning of radiographic findings in pulmonary PCM diagnosis. Methods: The epidemiological, clinical and radiological lung findings of 44 patients with paracoccidiodomycosis (PCM) were evaluated. Patients were divided into two groups of 23 and 21 individuals according to the presence (group 1) or absence (group 2) of chest X-ray abnormalities, respectively, and their clinical data was analyzed with the aid of statistical tools. Results: As a general rule, patients were rural workers, young adult males and smokers -group 1 and 2, respectively: males (91.3% and 66.7%); mean age (44.4 and 27.9 year-old); smoking (34.7% and 71.4 %); acute/subacute presentation (38.1% and 21.7%); chronic presentation (61.9% and 78.3%). The most frequent respiratory manifestations were -group 1 and 2, respectively: cough (25% and 11.4%) and dyspnea (22.7% and 6.8%). No statistical difference was observed in pulmonary signs and symptoms between patients with or without radiographic abnormalities. The most frequent radiological finding was nodular (23.8%) or nodular-fibrous (19%), bilateral (90.5%) and diffuse infiltrates (85.7%). Conclusions: Absence of statistical difference in pulmonary signs and symptoms between these two groups of patients with PCM indicates clinical-radiological dissociation. A simplified classification of radiological lung PCM findings is suggested, based on correlation of these data and current literature review.

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Gallium-67 imaging in a patient with paracoccidioidomycosis: a case report

Cited by 4 publications

References 7 publications

The contribution of ultrasonography and computed tomography in the evaluation of abdominal involvement in paracoccidioidomycosis

The contribution of ultrasonography and computed tomography in the evaluation of abdominal involvement in paracoccidioidomycosis

Paracoccidioidomycosis disease (Lutz-Splendore-Almeida disease): Additional workup, differential diagnosis, cure control

Pulmonary paracoccidoidomycosis: radiology and clinical-epidemiological evaluation

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