Lethal effect of oxamniquine and praziquantel on mice experimentally infected with Schistosoma mansoni

Abstract

Lethality caused by administration of oxamniquine and praziquantel to mice infected with Schistosoma mansoni, and their respective controls (uninfected), has been studied. As the results indicate, the infected animals clearly showed higher mortality rates when praziquantel was used. Surprisingly, it may be noted that exactly the contrary occurs in relation to the use of oxamniquine, inasmuch as marked higher mortality rates were seen in the control animals (uninfected). These observations lead to the conclusion that further toxicological studies of antischistosomal drugs using. S. mansoni infected animals are needed.

Comparative Study on Clinical Efficacy and Safety of Formulated and Marketed Myrrh Extract in Capsules

“…Further studies revealed a lethal effect for the coadministration of oxamniquine and praziquantel at large doses to experimental animals [12,13]. The bioavailability, side effects, and toxicity of praziquantel are increased in the presence of liver disease [14].…”