Genotoxic activity of Praziquantel1To Dora Valencia (in memoriam).1

Montero, Regina; Ostrosky, Patricia

doi:10.1016/s1383-5742(97)00027-6

Cited by 35 publications

(7 citation statements)

References 62 publications

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“…Administration of PZQ in the young child resulted in some putative side-effects, although many had resolved by 24 hours after treatment and even fewer were present 21 days after treatment, evidence of their mild and transient nature, and in accordance with previous observations. An obvious caveat for our data is the fact that symptoms were being reported by the mother on behalf of the child 46 . Interestingly, mothers reported significantly more side-effects one day after they received treatment, particularly dizziness (percentage difference = +10%), sleepiness (+15%), fatigue (+16%), vertigo (+14%) and cramps (+11%), than their children, possibly due to the higher prevalence and mean intensity of S. mansoni infections recorded in the mothers.…”

Section: Discussionmentioning

confidence: 93%

Treatment of intestinal schistosomiasis in Ugandan preschool children: best diagnosis, treatment efficacy and side-effects, and an extended praziquantel dosing pole

Sousa-Figueiredo

Pleasant

Day

et al. 2010

International Health

157

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SummaryThe Ugandan national control programme for schistosomiasis has no clear policy for inclusion of preschool-children (≤5 years old) children. To re-balance this health inequality, we sought to identify best diagnosis of intestinal schistosomiasis, observe treatment safety and efficacy of praziquantel (PZQ), and extend the current WHO dose pole for chemotherapy. We examined and treated 363 preschool children from shoreline villages of Lakes Albert and Victoria, and found that 62·3% (CI95 57·1–67·3) of the children were confirmed to have intestinal schistosomiasis. One day after treatment, children were reported as having headaches (3·6%), vomiting (9·4%), diarrhoea (10·9%) and urticaria/rash (8·9%) with amelioration at 21-day follow-up, where the parasitological cure rate was found to be 100·0%. Height and weight data were collected from a further 3303 preschool children to establish and validate an extended PZQ dose pole that now includes two new height-intervals: 60–84 cm for one-half tablet and 84–99 cm for three-quarter tablet divisions; which would result in 97·6% of children receiving an acceptable dose (30–60 mg/kg). To conclude, preschool children in lakeshore communities of Uganda are at significant risk of intestinal schistosomiasis; we now strongly advocate for their immediate inclusion within the national control programme to eliminate this health inequity.

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Section: Discussionmentioning

confidence: 93%

Treatment of intestinal schistosomiasis in Ugandan preschool children: best diagnosis, treatment efficacy and side-effects, and an extended praziquantel dosing pole

Sousa-Figueiredo

Pleasant

Day

et al. 2010

International Health

157

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“…This can subsequently cause nitrosative and oxidative damage to nucleic acids, and this damage may play a part in the initiation and/or promotion of steps in the development of CCA [ 36 – 38 ]. Extensive use of repeated doses of PZQ may be a specific factor which needs to be evaluated in relation to the use of this drug and the development of neoplasms in humans [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

Association between praziquantel treatment and cholangiocarcinoma: a hospital-based matched case–control study

et al. 2015

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BackgroundInfection by the liver fluke, Opisthorchis viverrini, remains an important public health problem in Thailand and has resulted in the highest prevalence of infection and incidence of subsequent cholangiocarcinoma (CCA) in the world. Praziquantel (PZQ) is the antihelminthic drug of choice for treatment. Previous studies in hamsters showed that repeated infection and PZQ treatment could increase the risk of CCA. However, the few available epidemiology studies in humans have shown unclear evidence of an increased risk of CCA with frequency of PZQ intake. The present study investigated the relationship between the number of repeated PZQ treatments and CCA.MethodsA hospital-based matched case–control study was conducted. All cases and controls were inpatients of a tertiary hospital in Northeast Thailand. During 2012–2014 a total of 210 incident cases of pathologically diagnosed CCA and 840 control subjects were selected from a hospital inpatient database (four controls per case). The four recruited controls were individually matched with CCA cases by gender, age and date of admission. Data were collected in face-to-face interviews using a standardised pre-tested questionnaire. Multivariable conditional logistic regression was used in the analysis of the data.ResultsThe frequencies of PZQ usage among the 210 cases and 840 controls were 48.6 vs. 66.0 for never, 32.9 vs. 24.4 for once, 8.6 vs. 4.9 for twice, and 10.0 % vs. 4.8 % for more than twice, respectively. There was a statistically significant dose–response relationship (p < 0.001). Compared with subjects who never used PZQ, those who used the medication once, twice, and more than twice were 1.49, 1.82, and 2.30 times more likely to develop CCA (95 % confidence intervals: 1.02 - 2.20, 0.92 - 3.60, and 1.20 - 4.40). These odds ratios (adjusted ORs) had already been adjusted for the effects of eating raw fish, a family history of cancer, and highest educational attainment. Additional PZQ usage increased the odds of developing CCA by 23.0 % (adjusted OR = 1.23; 95 % CI: 1.07 - 1.43).ConclusionsThe findings show that repeated PZQ treatments are associated with an increased risk of CCA. Paradoxically, this contradicts the common belief that repeated PZQ treatments decrease the risk of CCA. The study also showed a strong association between the number of repeated PZQ treatments and the consumption of raw freshwater fish. This suggests that repeated PZQ treatments may be a surrogate marker of habit of eating raw fish.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-015-1788-6) contains supplementary material, which is available to authorized users.

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“…Furthermore, these drugs may induce side effects, such as vomiting, nausea, headache, and hepatomegaly [20]. Particularly in the case of praziquantel, genotoxic potential has been established [21], which suggests the need to find other effective drugs that are safe and inexpensive. Taking into consideration this information, the aim of the present study was to explore the role of B. thuringiensis toxins against the adult cestode and egg capsules of D. caninum evaluating its in vitro effects on eggs development and survival and adult worm tegument thickness, which are key processes in the maintenance of the infectious cycle in dogs and humans.…”

Section: Introductionmentioning

confidence: 99%

In VitroOvicidal and Cestocidal Effects of Toxins fromBacillus thuringiensison the Canine and Human ParasiteDipylidium caninum

Peña

Jiménez

Hallal-Calleros

et al. 2013

BioMed Research International

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Bacillus thuringiensis is a gram-positive soil-dwelling bacterium that is commonly used as a biological pesticide. This bacterium may also be used for biological control of helminth parasites in domestic animals. In this study, we evaluated the possible ovicidal and cestocidal effects of a total protein extract of B. thuringiensis native strains on the zoonotic cestode parasite of dogs, Dipylidium caninum (D. caninum). Dose and time response curves were determined by coincubating B. thuringiensis proteins at concentration ranging from 100 to 1000 μg/mL along with 4000 egg capsules of D. caninum. Egg viability was evaluated using the trypan blue exclusion test. The lethal concentration of toxins on eggs was 600 μg/ml, and the best incubation time to produce this effect was 3 h. In the adult stage, the motility and the thickness of the tegument were used as indicators of damage. The motility was inhibited by 100% after 8 hours of culture compared to the control group, while the thickness of the cestode was reduced by 34%. Conclusively, proteins of the strain GP526 of B. thuringiensis directly act upon D. caninum showing ovicidal and cestocidal effects. Thus, B. thuringiensis is proposed as a potential biological control agent against this zoonosis.

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Genotoxic activity of Praziquantel1To Dora Valencia (in memoriam).1

Cited by 35 publications

References 62 publications

Treatment of intestinal schistosomiasis in Ugandan preschool children: best diagnosis, treatment efficacy and side-effects, and an extended praziquantel dosing pole

Treatment of intestinal schistosomiasis in Ugandan preschool children: best diagnosis, treatment efficacy and side-effects, and an extended praziquantel dosing pole

Association between praziquantel treatment and cholangiocarcinoma: a hospital-based matched case–control study

In VitroOvicidal and Cestocidal Effects of Toxins fromBacillus thuringiensison the Canine and Human ParasiteDipylidium caninum

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