Coral snake venoms: mode of action and pathophysiology of experimental envenomation

Brazil, Oswald Vital

doi:10.1590/s0036-46651987000300001

Cited by 74 publications

(16 citation statements)

References 8 publications

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“…Micrurus venoms are known to possess neurotoxic properties 37 . In most symptomatic cases neuromuscular paralysis is the most prominent and is caused by postsynaptic motor end-plate blockage of acetylcholine receptors, which produces similar effects to those seen in myasthenia gravis 18 and curare poisoning 24 .…”

Section: Discussionmentioning

confidence: 99%

Envenomation by Micrurus coral snakes in the Brazilian Amazon region: report of two cases

Pardal

Gadelha

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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SUMMARYTwo cases of proven coral snake bites were reported in Belém, Pará State, Brazil. The first case was a severe one caused by Micrurus surinamensis. The patient required mechanical ventilation due to acute respiratory failure. The second case showed just mild signs of envenomation caused by Micrurus filiformis. Both patients received specific Micrurus antivenom and were discharged without further complications. Coral snake bites are scarcely reported in the Amazon region and there is a broad spectrum of clinical manifestations, varying from extremely mild to those which may rapidly lead to death if the patient is not treated as soon as possible.

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Section: Discussionmentioning

confidence: 99%

Envenomation by Micrurus coral snakes in the Brazilian Amazon region: report of two cases

Pardal

Gadelha

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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“…A inclusão do veneno de M. lemniscatus deve-se, provavelmente, aos estudos pioneiros e únicos de Vital Brazil [4,16]. Entretanto, dificuldades com a obtenção e manutenção de espécimes em cativeiro, extração de veneno e garantia de ter as espécies inclusas no pool levaram a um desequilíbrio na produção e no compromisso dos produtores de imunobiológicos.…”

Section: /6unclassified

Reconhecimento de frações do veneno de cobras corais brasileiras pelo soro antielapídico

Vidal¹,

Nascimento²,

Pessoa³

et al. 2015

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. Results: Variability in venom components and in the ability to recognize such components was demonstrated by the antielapid serum. Based on the western-blotting technique, the antielapid serum from Ezequiel Dias Foundation was able to recognize most, but not all the components present in the analyzed venoms. Conclusions:The results suggest restricted efficacy of the antielapid serum, due to its limitations against species from the Amazon region, reinforcing the need for a review of intraspecific and interspecific studies of Micrurus venoms.

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“…venoms, with combined action (pre-and postsynaptic) such as those of M. corallinus from Brazil, M. nigrocinctus from Costa Rica, and M. dumerilii and M. mipartitus from Colombia. They inhibit acetylcholine release by interfering with Ca ++ metabolism (Brazil 1987;Da Silva Jr and Bucaretchi 2003;Rey-Suárez et al 2011).…”

Section: Neurotoxicitymentioning

confidence: 99%

“…and Pelamis platurus venoms is the postsynaptic blockade by competitive inhibition of acetylcholine (a-neurotoxins). This group of toxins belongs to the three-finger toxin superfamily (3FTx) (Otero 2007(Otero , 2014Rey-Suárez et al 2012;Da Silva and Bucaretchi 2003;Brazil 1987;Mori et al 1989). The venom of M. dissoleucus from Colombia also has postsynaptic action combined with myotoxic effect (Renjifo et al 2012), the latter being similar to that previously described for M. mipartitus venom from Colombia (Otero et al 1992b).…”

Section: Neurotoxicitymentioning

confidence: 99%

Snakebites in Colombia

Otero-Patiño

2014

Toxinology

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Nearly 4,000 snakebites are annually reported in Colombia -90-95 % are inflicted by pit vipers from Bothrops, Porthidium, Bothriechis, Bothriopsis, and Bothrocophias genera, specially by B. asper (50-80 %); 2 % by the bushmaster Lachesis spp.; 1 % by the rattle snake Crotalus durissus cumanensis; 1 % by coral snakes (Micrurus spp.); and the remaining 1-5 % by snakes of aglyphous and opisthoglyphous dentition, mainly from Colubridae family. The Colombian fatality rate of snakebite envenoming is 1-3 %, the highest percentage in the Orinochian and Amazonian regions, whereas 6 % of patients suffer some type of sequelae, mainly as a result of dermonecrosis and myonecrosis. B. asper is responsible for 60-90 % of deaths secondary to snakebites. In this chapter, the clinical and epidemiological aspects of bothropic, lachesic, crotalic, and elapidic envenomations are described, with specific features for the country, as well as the actual knowledge of venom composition and actions.

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Coral snake venoms: mode of action and pathophysiology of experimental envenomation

Abstract: coral snake venoms: mode of action and pathophysiology of experimental envenomation. Rev.

Cited by 74 publications

References 8 publications

Envenomation by Micrurus coral snakes in the Brazilian Amazon region: report of two cases

Envenomation by Micrurus coral snakes in the Brazilian Amazon region: report of two cases

Reconhecimento de frações do veneno de cobras corais brasileiras pelo soro antielapídico

Snakebites in Colombia

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