Reconhecimento de frações do veneno de cobras corais brasileiras pelo soro antielapídico

Abstract

Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. Results: Variability in venom components and in the ability to recognize such components was demonstrated by the antielapid serum. Based on the western-blotting technique, the antielapid serum from Ezequiel Dias Foundation was able to recognize most, but not all the components present in the analyzed venoms. Conclusions:The results suggest restricted efficacy of the antielapid serum, due to its limitations against species from the Amazon region, reinforcing the need for a review of intraspecific and interspecific studies of Micrurus venoms.

In vivo treatment with varespladib, a phospholipase A2 inhibitor, prevents the peripheral neurotoxicity and systemic disorders induced by Micrurus corallinus (coral snake) venom in rats

“…distributed across the country(Higashi et al, 1995;Silva Jr. et al, 1991;Abreu et al, 2008;Tanaka et al, 2010;Vidal et al, 2015; Floriano et al, 2019). In this study, we also observed the bivalent antivenom was not able to prevent the worst clinical condition associated to the neurotoxic action of M. corallinus venom when administered alone; envenomed animals treated with antivenom evolved to a severe neuromuscular paralysis affecting their respiratory function, with one death occurring before completing 120 min of clinical monitoring.…”