Partial efficacy of a Brazilian coralsnake antivenom and varespladib in neutralizing distinct toxic effects induced by sublethal Micrurus dumerilii carinicauda envenoming in rats

Considerations for the development of a field-based medical device for the administration of adjunctive therapies for snakebite envenoming

“…This approach has been demonstrated when a combination of marimastat and varespladib showed synergistic efficacy over the individual drugs and prevented mortality in mice when exposed to venom from the most medically important vipers of South Asia, Africa, and Central America( Albulescu et al, 2020b ; Xie et al, 2020a ). There are also a growing number of examples demonstrating the synergistic effects of small molecule drugs when used in combination with traditional biologic antivenoms (see section 4.5 ) ( de Souza et al, 2022 ; Lay et al, 2023 ; Silva-Carvalho et al, 2022 ; Silva et al, 2021 ).…”