Holochilus brasiliensis nanus Thomas, 1897: sugestão de modelo experimental para filariose, leishmaniose e esquistossomose

Bastos, Othon; Sadigursky, Moysés; Nascimento, Maria do Desterro Soares Brandão; Brazil, Reginaldo Peçanha; Holanda, João Carvalho de

doi:10.1590/s0036-46651984000600004

Cited by 15 publications

(14 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, there have been only two reports where N. rattus (formerly named N. squamipes amazonicus) were found naturally infected (Bastos et al 1982(Bastos et al , 1984.…”

Section: Abstract: Nectomys Rattus -Nectomys Squamipes -Wild Rodent mentioning

confidence: 99%

Susceptibility of Nectomys rattus (Pelzen, 1883) to experimental infection with Schistosoma mansoni (Sambon, 1907): a potential reservoir in Brazil

Ribeiro

Maldonado

D’Andrea

et al. 1998

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

The aim of the present research was to evaluate the potential of Nectomys rattus, the "water rat", to develop Schistosoma mansoni infection. Comparison Key words: Nectomys rattus -Nectomys squamipes -wild rodent -Schistosoma mansoni -experimental infectionThe occurrence of wild populations of small rodent naturally infected in endemic schistosomiasis areas had been considered as an additional complication factor for the control of the disease (Rey 1993).The species Nectomys squamipes, the "water rat", is one of the most important non-human hosts for Schistosoma mansoni in Brazil (Antunes et al. 1973, Picot 1992. This species excretes viable eggs of the parasite during its hole life-span (RodriguesSilva 1988) and shows strong fitness to parasitism . Furthermore, N. squamipes has a high susceptibility to experimental infection (Souza et al. 1992), reinfection (Maldonado Jr. et al. 1994), and with a moderate pathogenic response (Silva & Andrade 1989 at the eastern Brazilian coast, from north of the municipality of São Lourenço da Mata (State of Pernambuco) to the Amazon river. That new given designation is N. rattus (2n=52).N. squamipes (2n=56) distribution has been restricted to the Atlantic coast of Brazil, in the basins of São Francisco river and Paraná river, as well as in the small independent basins of southern São Lourenço da Mata, in eastern Brazil.The broad distribution of N. rattus includes endemic areas of schistosomiasis apart from those where N. squamipes are found. However, there have been only two reports where N. rattus (formerly named N. squamipes amazonicus) were found naturally infected (Bastos et al. 1982(Bastos et al. , 1984.The aim of this research was to evaluate the potential of N. rattus to develop S. mansoni infection, and its ability to complete the parasite's life cycle under experimental conditions. All results were compared to the N. squamipes relation with S. mansoni infection. MATERIALS AND METHODSExperimental groups -Thirty seven specimens of N. rattus and 58 specimens of N. squamipes of both sexes, aged 3 to 5 months and weighing 250 to 300 g were used. All experimental animals were raised in our laboratory colonies (D'Andrea et al. 1996). The colony of the N. rattus derived from animals captured in the State of Goiás

show abstract

“…However, there have been only two reports where N. rattus (formerly named N. squamipes amazonicus) were found naturally infected (Bastos et al 1982(Bastos et al , 1984.…”

Section: Abstract: Nectomys Rattus -Nectomys Squamipes -Wild Rodent mentioning

confidence: 99%

Susceptibility of Nectomys rattus (Pelzen, 1883) to experimental infection with Schistosoma mansoni (Sambon, 1907): a potential reservoir in Brazil

Ribeiro

Maldonado

D’Andrea

et al. 1998

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

show abstract

“…Rodrigues & Ferreira (1969) captured N. squamipes rodents naturally infected in São Paulo State, where they found new endemic human foci of the parasitosis. Bastos et al (1984) captured N. squamipes in Maranhão State and reported that 70,6% of animals were parasitized. Silva & Andrade (1989) observed that N. squamipes had an important role in the maintenance of schistosomiasis in the rural area of Planalto (BA) because human prevalence was 3.26%, whereas rodent prevalence was 47%.…”

Section: Small Mammals Naturally Infected By S Mansonimentioning

confidence: 99%

“…Studies of the participation of these rodents in schistosomiasis only mention N. squamipes, except for Bastos et al (1982Bastos et al ( , 1984, who reported naturally infected Nectomys squamipes amazonicus (currently Nectomys rattus (Pelzen (1883)). The water-rat Nectomys squamipes (Sigmodontinae) occurs in the Atlantic Forest, Rio São Francisco and Paraná Basins, and in small basins of Eastern Brazil below São Lourenço da Mata, Pernanbuco State, embracing the South, Southern and part of the Northeast regions (Fig.…”

Section: The Most Important Species Of Reservoir: Water-ratsmentioning

confidence: 99%

“…The emission peak during the day would be more related to human infection, as this is the time of greatest activity for the local people and of increased contact with contaminated water bodies, and the crepuscular peak could be related to infection in rodents, as they have twilight/nocturnal activity ( Fig. 9 and Previous studies have attempted to show differences between rodents and human S. mansoni strains through the following factors: external morphology of adult worms , pathogenicity in mice (Bastos et al, 1984, Silva & Andrade 1989, compatibility with snails (Bastos et al, 1984;Dias et al, 1978), sensitivity to drugs www.intechopen.com (Souza et al 1992) and iso-enzyme patterns (Oliveira, 1996). These biological differences, coupled with the existence of two different patterns of cercariae emission (diurnal and crepuscular / nocturnal), led to the hypothesi s t h a t t h e r e c o u l d b e d i f f e r e n c e s a t t h e molecular level between the human and rodent strains and between different geographical regions (Gentile & Oliveira, 2008).…”

Section: On a Regional Scalementioning

confidence: 99%

See 1 more Smart Citation

The Role of Wild Rodents in the Transmission of Schistosoma mansoni in Brazil

Gentile¹,

Soares²,

Barreto³

et al. 2012

Schistosomiasis

View full text Add to dashboard Cite

“…Estudos sobre a anatomia-patológica e a imuno-patologia em Holochilus esquistossomóticos vêm sendo realizados no Programa de Imunologia da Universidade Federal do Maranhão 4,5 . Entretanto, não são conhecidos dados bioquí-micos do sangue desses animais.…”

unclassified

Observações sobre os níveis glicêmicos de Holochilus brasiliensis nanus Thomas, 1897, hospedeiro natural do Schistosoma mansoni na Pré-Amazônia

1985

Self Cite

View full text Add to dashboard Cite

RESUMO: Roedores silvestres, nascidos em biotério, descendentes de Holochilus b. nanus, capturados na região da Baixada Maranhense, localizada na Pré-Amazô-nia, foram infectados experimentalmente com Schistosoma mansoni, procedente da mesma Região, com o objetivo de verificar a influência da infecção sobre os níveis glicêmicos. Um grupo de roedores não infectados tiveram, também, seus níveis glicê-micos determinados, para o conhecimento da concentração normal de glicose. O estudo procedeu distinguindo os animais, tanto os normais quanto os infectados, por sexo, regime alimentar e idade de infecção. A quantificação da glicose sérica foi feita pelo método da Orto-Toluidina, após sangrias semanais pelo plexo oftálmico, sempre no mesmo horário. Os resultados mostraram que ocorreu elevação de pesos corporais de todos os animais normais, durante suas maturações, ao passo que, os animais infectados, tiveram seus pesos em decréscimo, durante a evolução da infecção. Os ní-veis glicêmicos estudados nos animais normais mostraram que as fêmeas possuem nível mais baixo e estável do que os machos, independente de terem sido alimentados ou não. Os animais infectados aos 30 dias de vida tiveram seus níveis glicêmicos em declínio à proporção que a infecção evoluía, provavelmente, devido ao acometimento dos órgãos, como baço, fígado e pâncreas; enquanto que, os animais infectados aos 40 dias de vida, tiveram seus níveis de glicose, durante as 8 semanas de infecção, sem diferença significativa entre eles. O número de vermes adultos recuperados nos animais infectados com 30 dias de vida foi maior do que o número encontrado nos roedores do outro grupo. Os dados informaram, também, que, a idade ideal para a infecção deste novo modelo experimental, deva ser a de 30 dias de vida, semelhante a outros, como camundongos. UNITERMOS:Holochilus brasiliensis nanus, infecção experimental. Schistosoma mansoni. Glicose no sangue, análise.

show abstract

Holochilus brasiliensis nanus Thomas, 1897: sugestão de modelo experimental para filariose, leishmaniose e esquistossomose

Cited by 15 publications

References 8 publications

Susceptibility of Nectomys rattus (Pelzen, 1883) to experimental infection with Schistosoma mansoni (Sambon, 1907): a potential reservoir in Brazil

Susceptibility of Nectomys rattus (Pelzen, 1883) to experimental infection with Schistosoma mansoni (Sambon, 1907): a potential reservoir in Brazil

The Role of Wild Rodents in the Transmission of Schistosoma mansoni in Brazil

Observações sobre os níveis glicêmicos de Holochilus brasiliensis nanus Thomas, 1897, hospedeiro natural do Schistosoma mansoni na Pré-Amazônia

Contact Info

Product

Resources

About