Observações sobre os níveis glicêmicos de Holochilus brasiliensis nanus Thomas, 1897, hospedeiro natural do Schistosoma mansoni na Pré-Amazônia

Bastos, Othon; Leal, Grace Mary J. Pires; Salgado, Bernardete Jorge

doi:10.1590/s0034-89101985000600004

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…Couto et al (2008) observed the same energy imbalance in an experimental study of metabolic changes in undernourished mice infected by S. mansoni. In a study of Holochilus brasiliensis nanus from a pre-Amazon region naturally infected with S. mansoni, Bastos et al (1985) demonstrated that the animals infected at 30 days of age suffered reduced glycemic levels as the infection evolved, while those infected at 40 days of age showed no significant difference in plasma glucose levels during eight weeks of infection when compared to animals uninfected by S. mansoni. In the present study, S. mansoni infection in rodents caused loss of glycemic homeostasis, resulting in an increase of free plasma glucose as a typical response observed under conditions of physiological stress.…”

Section: Discussionmentioning

confidence: 99%

Biochemical and histological changes in liver ofNectomys squamipes naturally infected bySchistosoma mansoni

Neto

Alves

et al. 2013

Rev. Bras. Parasitol. Vet.

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The South American water rat Nectomys squamipes is a wild mammal reservoir of Schistosoma mansoni in Brazil. In the present study, wild rodents were collected in the field and categorized into two groups: infected and uninfected by S. mansoni. Blood was collected to analyze changes in the serum glucose level (mg/dL) and liver fragments were used to determine the hepatic glycogen content (mg of glucose/g tissue). The histological examination showed inflammatory granulomatous lesions in different phases of development in the liver of rodents naturally infected with S. mansoni, in some cases with total or partial occlusion of the vascular lumen. Early lesions were characterized by the presence of inflammatory infiltrate around morphologically intact recently deposited eggs. Despite the significance of these histological lesions, the biochemical changes differed in extent. N. squamipes naturally infected by S. mansoni showed no variation in hepatic glycogen reserves. These findings were accompanied by a significant increase in plasma glucose contents, probably as a consequence of amino acids deamination, which are degraded, resulting in the formation of intermediates used as precursors for the glucose formation, without compromising the reserves of liver glycogen. In the wild, naturally infected N. squamipes can maintain S. mansoni infections without undergoing alterations in its carbohydrate metabolism, which minimizes the deleterious effects of S. mansoni.Keywords: Biochemical alterations, rodents, wild reservoirs, alternative model. ResumoNectomys squamipes é um mamífero silvestre reservatório de Schistosoma mansoni no Brasil. No presente estudo, os roedores silvestres, colhidos no campo, foram classificados em dois grupos: infectado e não infectado por S. mansoni. O sangue foi colhido para análise da alteração no nível de glicose sérico (mg/dL) e fragmentos de fígado foram usados para determinar o conteúdo de glicogênio hepático (mg de glicose/g tecido). A análise histológica demonstrou lesões granulomatosas em diferentes fases de desenvolvimento no tecido hepático dos roedores naturalmente infectados com S. mansoni, localizados principalmente na região periportal, com total ou parcial oclusão do lúmen vascular. As lesões foram caracterizadas por presença de infiltrado inflamatório ao redor de ovos morfologicamente intactos recentemente depositados. Apesar da grande significância das lesões histológicas, as alterações bioquímicas não diferiram no mesmo

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Section: Discussionmentioning

confidence: 99%

Biochemical and histological changes in liver ofNectomys squamipes naturally infected bySchistosoma mansoni

Neto

Alves

et al. 2013

Rev. Bras. Parasitol. Vet.

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“…Moreover, it has been previously demonstrated that the blood glucose concentration of H. sciureus decreases progressively with the evolution of S. mansoni experimental infection, particularly in younger animals infected at 30 days old. However, animals infected at 40 days old did not show any major variation in blood glucose level and had a longer life span (Bastos et al, 1985), suggesting that the age of the animals, likely associated with the development of the immune system, contribute to a more balanced host-parasite relationship.…”

Section: Discussionmentioning

confidence: 97%

“…Furthermore, the metabolism of these animals during natural infection allows for an excessive accumulation of lipids in the liver (steatosis), which may prevent intense severe liver inflammatory reactions (Amaral et al, 2016). In the case of H. sciureus, studies have shown that experimental infection with S. mansoni causes a decrease in glucose concentrations in younger infected animals (30 days old), but not in older infected animals (40 days old) (Bastos et al, 1985). However, no study has proposed a similar investigation during natural infections and comparatively between males and females of H. sciureus rodents as yet.…”

Section: Introductionmentioning

confidence: 99%

Alterations in blood glucose concentration in wild rodents, Holochilus sciureus, naturally infected with Schistosoma mansoni

Rodrigues

Lira

Nogueira

et al. 2022

Rev. Bras. Parasitol. Vet.

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The present study aimed to evaluate the changes in peripheral blood glucose concentrations induced by Schistosoma mansoni infection in Holochilus sciureus rodents, a wild reservoir of the parasite. Glucose concentration was measured in the plasma of blood samples using a colorimetric enzymatic test. Biological parameters and S. mansoni burden in each rodent were also verified and correlated with glucose concentrations. A total of 76 H. sciureus were captured, out of which 20 (26%) were infected with S. mansoni (n=13 males and n=7 females). Although the parasite burden was comparable between the sexes, blood glucose concentration was lower in infected males and almost unchanged in females. Furthermore, histopathological data revealed that male rodents had a greater hepatic granulomatous inflammatory reaction than females. In addition, we also confirmed that the weight and total length of the analyzed animals had no effect on glucose levels. Therefore, natural infection with S. mansoni in H. sciureus may have a lower impact on glycemic homeostasis in females, which will help us understand the role of these rodents as reservoirs of S. mansoni.

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Observações sobre os níveis glicêmicos de Holochilus brasiliensis nanus Thomas, 1897, hospedeiro natural do Schistosoma mansoni na Pré-Amazônia

Cited by 2 publications

References 9 publications

Biochemical and histological changes in liver ofNectomys squamipes naturally infected bySchistosoma mansoni

Biochemical and histological changes in liver ofNectomys squamipes naturally infected bySchistosoma mansoni

Alterations in blood glucose concentration in wild rodents, Holochilus sciureus, naturally infected with Schistosoma mansoni

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