Resposta imune humoral de cães à vacina inativada, de cérebro de camundongos lactentes, utilizada nas campanhas anti-rábicas no Brasil

Almeida, Marilene Fernandes de; Aguiar, Elizabeth A. C.; Martorelli, Luzia Fátima Alves; Presotto, Douglas; Brandão, Marcelo Mendes; Pereira, O. A. C

doi:10.1590/s0034-89101997000600009

Cited by 13 publications

(14 citation statements)

References 10 publications

(7 reference statements)

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“…The authors concluded that puppies should receive a second vaccine dose as a complement of primevaccination to increase the antibodies titers. Similar results were observed in other studies (ALMEIDA et al, 1997;SEGHAIER et al, 1999;SILVA et al, 2009), reinforcing the need for complementation of primary vaccination in those animals receiving the first anti-RABV vaccine.…”

Section: Discussionsupporting

confidence: 89%

“…Vaccine quality, dose, age of primary vaccination, nutritional status, presence of concomitant infections, in addition to the individual immunological capacity may interfere with the indices of vaccine failure (SEGHAIER et al, 1999;ALMEIDA et al, 1997;MORTERS et al, 2014). As these factors were not evaluated in the present study, it is not possible to attribute to any of them the observed unresponsiveness to vaccination in many animals.…”

Section: Discussionmentioning

confidence: 88%

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Antibodies against rabies virus in dogs with and without history of vaccination in Santa Maria - RS - Brazil

et al. 2017

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The present study investigated the frequency and magnitude of neutralizing antibodies to rabies virus (RABV) in dogs with and without historic of vaccination in Santa Maria/RS. Group A included serum samples from 440 dogs with recent historic of vaccination against rabies, obtained during the 2015 rabies vaccination campaign. Group B included 300 serum samples from dogs submitted to the Veterinary Hospital of the Universidade Federal de Santa Maria in 2015, whose historic of rabies vaccination was unknown. Serum samples were submitted to the rapid fluorescent focus inhibition test (RFFIT) to detect neutralizing antibodies against RABV. In group A, 70.6% (310/440) of the samples had neutralizing antibody titers ≥0.5 international units per milliliter (IU mL-1), considered an indicative of protection against rabies by the World Health Organization. However, approximately 30% of the dogs did not contain antibodies in adequate levels. In group B, 42.3% (127/300) of the samples contained neutralizing antibody titers ≥0.5IU mL-1 and 57.7% (173/300) were negative or contained titers below of the value considered immunized. These results demonstrate that an important proportion of vaccinated dogs (~30%) did not develop adequate antibody levels, mainly those receiving a single vaccine dose. Serologic testing of animals with unknown historic of vaccination revealed relatively low vaccine coverage in the general dog population. Thus, reformulation of immunization strategies - especially the recommendation of a boost vaccination 30 days after the primary dose - and extension of vaccination campaigns are necessary to reach adequate levels and coverage of immunity against RABV in the canine population.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 88%

Antibodies against rabies virus in dogs with and without history of vaccination in Santa Maria - RS - Brazil

et al. 2017

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“…Em estudo objetivando avaliar o título protetor de cães um ano após a vacinação e nova avaliação 30 dias após o reforço vacinal, nos municípios de São Paulo e Paulínia, usando a técnica de RFFIT, foi verificado que 74,1% dos animais possuíam títulos menores que 0,5UI/ml após 12 meses de vacinação 3 , resultados acima dos encontrados neste estudo. No mesmo estudo foi verificada a independência entre a condição de reagente e o estado nutricional dos cães, já o número de vacinas anteriores teve associação com a resposta imune, diferente do aqui identificado.…”

Section: Discussionunclassified

Titulação de anticorpos contra o vírus da raiva em cães, em Campo Grande, MS, na Campanha Anti-Rábica de 2003

Rigo

Honer

2006

Rev. Soc. Bras. Med. Trop.

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“…The inactivated suckling mouse brain rabies vaccine (SMBV) presents an adequate antigenic mass, producing immunity with few adverse side effects in the majority of the animal population 4 . Since a low immunogenic response had been observed in studies undertaken with individuals and animals immunized with the inactivated suckling mouse brain rabies vaccine, a booster dose was found necessary 5,6,7,8,9 . The SMBV is used in Brazilian national vaccination campaigns against rabies, in dogs and cats, carried out, annually, in September.…”

Section: Introductionmentioning

confidence: 99%

Resposta imune humoral de macacos-pregos (Cebus apella) após vacinação com vacina anti-rábica inativada produzida em cérebros de camundongos lactentes: comparação de dois esquemas de imunização

Passos¹,

Germano

Fedullo³

et al. 2005

Braz. J. Vet. Res. Anim. Sci.

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Two groups of adult capuchin monkeys (Cebus apella) were vaccinated i.m. against rabies with inactivated suckling mouse brain rabies vaccine (SMBV), at the Zoo Park Foundation in São Paulo, SP, Brazil. The animals had not been immunized against rabies at any time before. Group I consisted of nine animals, to which were given three 1.0mL doses on days 0 and 30, plus a booster on day 210. Group II comprehended ten animals, to which were given two 1.0mL doses: one, on day 0 and, another, a booster, on day 210. The blood samples were collected on days 0, 30, 60, 90, 150, 210, 240, 300 and 365, being the titrated neutralizing antibodies determined by the simplified fluorescent focus inhibition technique. The vaccine induced immune responses with neutralizing antibody titers above 0.5 IU/m in both groups of capuchin monkeys; however, they were short, lasting 54.9 ± 57.0 days and 36.1 ± 60.2 days in Groups I and II, respectively, after primo-vaccination, and 62.6 ± 74.0 and 86.4 ± 61.5 days in Groups I and II, respectively, after a booster. No statistically significant differences were observed out between the two groups studied (p > 0.05).

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Resposta imune humoral de cães à vacina inativada, de cérebro de camundongos lactentes, utilizada nas campanhas anti-rábicas no Brasil

Cited by 13 publications

References 10 publications

Antibodies against rabies virus in dogs with and without history of vaccination in Santa Maria - RS - Brazil

Antibodies against rabies virus in dogs with and without history of vaccination in Santa Maria - RS - Brazil

Titulação de anticorpos contra o vírus da raiva em cães, em Campo Grande, MS, na Campanha Anti-Rábica de 2003

Resposta imune humoral de macacos-pregos (Cebus apella) após vacinação com vacina anti-rábica inativada produzida em cérebros de camundongos lactentes: comparação de dois esquemas de imunização

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