Titulação de anticorpos contra o vírus da raiva em cães, em Campo Grande, MS, na Campanha Anti-Rábica de 2003

Rigo, Leonardo; Honer, Michael Robin

doi:10.1590/s0037-86822006000600008

Cited by 10 publications

(9 citation statements)

References 9 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There were animals in other groups with past vaccination history who did not have adequate protection. Similar patterns of data had been observed by research groups in other countries as well [33–35]. However, Barth et al, indicates by analyzing many experimental results that dogs have a very high probability of survival after a later rabies infection, even if serum does not contain detectable anti-rabies antibodies irrespective of the period of time elapsed since the vaccination [18].…”

Section: Discussionsupporting

confidence: 74%

Sero-prevalence of virus neutralizing antibodies for rabies in different groups of dogs following vaccination

et al. 2017

View full text Add to dashboard Cite

BackgroundMass vaccination of dogs is considered fundamental for national rabies control programmes in Sri Lanka, as dog is the main reservoir and transmitter of the disease.MethodsDogs were followed to determine the sero-prevalence of antibodies to the rabies virus. Altogether 510 previously vaccinated and unvaccinated dogs with owners (domestic dogs) and dogs without owners (stray dogs) of the local guard dog breed in different age groups recruited from Kalutara District, Sri Lanka. The dogs were vaccinated with a monovalent inactivated vaccine intramuscularly and serum antibody titres on days 0, 30, 180 and 360 were determined by the Rapid Fluorescent Focus Inhibition Test (RFFIT).ResultsThe results indicated, a single dose of anti-rabies vaccination fails to generate a protective level of immunity (0.5 IU/ml) which lasts until 1 year in 40.42% of dogs without owners and 57.14% of previously unvaccinated juvenile (age: 3 months to 1 year) dogs with owners. More than one vaccination would help to maintain antibody titres above the protective level in the majority of dogs. The pattern of antibody titre development in annually vaccinated and irregularly vaccinated (not annual) adult dogs with owners is closely similar irrespective of regularity in vaccination. Previously vaccinated animals have higher (2 IU/ml) antibody titres to begin with and have a higher antibody titre on day 360 too. They show a very good antibody titre by day 180. Unvaccinated animals start with low antibody titre and return to low titres by day 360, but have a satisfactory antibody titre by day 180.ConclusionsA single dose of anti-rabies vaccination is not sufficient for the maintenance of antibody titres for a period of 1 year in puppies, juvenile dogs with owners and in dogs without owners. Maternal antibodies do not provide adequate protection to puppies of previously vaccinated dams and puppies of previously unvaccinated dams. Immunity development after vaccination seems to be closely similar in both the groups of puppies.

show abstract

Section: Discussionsupporting

confidence: 74%

Sero-prevalence of virus neutralizing antibodies for rabies in different groups of dogs following vaccination

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The differences found in the level of seroconversion among animal shelters (Fig.4) allow us to assume that there are anthropogenic variables that influence the immune response of vaccinated animals. These occur in addition to the biological responses that affect the dogs and cats and are attributable to factors such as nutritional status or health status (Almeida et al 1997, Rigo & Honer 2006, Tordo et al 2005.…”

Section: Discussionmentioning

confidence: 99%

Low level of the immune response against rabies virus in dogs and cats, a cross-sectional study in sheltered animals, Santander, Colombia

2018

View full text Add to dashboard Cite

Rabies is an incurable and fatal progressive viral encephalomyelitis that causes approximately 61,000 deaths a year globally mainly by dog bites, which show the importance of anti-rabies vaccination in dogs to achieve elimination of the disease. In Colombia, multiple cases of human rabies transmitted by dogs and cats have been reported since 1999, showing an increased significance of cats in the transmission of rabies, mainly in rabies of wild origin. Therefore, the aim of the present study was to evaluate the development of neutralizing antibodies in dogs and cats during the mass vaccination campaign of the second half of 2015 in the city of Bucaramanga. For this purpose, a descriptive cross-sectional study with convenience sampling was conducted in 382 dogs and cats (295 dogs, 87 cats), and an evaluation of the humoral immune response of the animals was performed by quantitative ELISA. The prevalence of optimal neutralizing antibodies (>0.5 IU/ml) was only 32.76% (95% CI=28.05-37.46%) in the entire population studied and most of the animals did not have an adequate response to the vaccination, or seroconversion was not detected on them (65.45-95% confidence interval, CI=60.68-70.21%). Significant difference was found between the neutralizing antibody titers in cats and dogs, with a higher neutralizing response in cats. In conclusion, although mass vaccination campaigns for dogs and cats are the most important measure to interrupt virus circulation among the animals, achievement of a good neutralizing immune response in the animals is useful to demonstrate that vaccination has been successful, allowing the maintenance of the required minimum levels of population immunity. These results will allow the implementation of corrective measures in Bucaramanga to achieve better seroconversion rates. Other cities are expected to implement similar seroconversion assessments to verify the quality of effective anti-rabies vaccination in animal populations.

show abstract

“…Rigo and Honer [18] found similar results when analyzing 333 canine sera before the mass vaccination in 2003 in Campo Grande, state of Mato Grosso do Sul, Midwestern Brazil, and found a reactivity proportion of approximately 50%.…”

Section: Resultsmentioning

confidence: 63%

Humoral immune response in dogs and cats vaccinated against rabies in southeastern Brazil

Albas

Picolo

Soares

et al. 2013

J Venom Anim Toxins incl Trop Dis

View full text Add to dashboard Cite

BackgroundBrazil holds annual nationwide public campaigns to vaccinate dogs and cats against rabies. The presence of rabies antibodies in these animals, which are among the main transmitters of rabies to humans, is a good indicator that they are immunized and protected.MethodsIn the present study we analyzed 834 serum samples from dogs and cats from the Southeast of Brazil (Presidente Prudente and Dracena cities), 12 months after the 2009 vaccination campaign. We used the technique known as rapid fluorescent focus inhibition test (RFFIT) and considered reactant those sera with values higher 0.5 IU/mL.Results and discussionReactant sample results in Presidente Prudente were 153 (51.0%) for dogs and 59 (32.6%) for cats, and in Dracena 110 (52.1%) for dogs and 71 (50.0%) for cats. We discussed vaccine coverage of animals involved in this experiment, and observed low titers < 0.5 IU/mL, especially in cats from Presidente Prudente.ConclusionAccording to the results presented in our experiment, we suggest that titers below 0.5 IU/mL are worrisome and that, for multiple reasons, animals should be immunized against rabies in the period between public vaccination campaigns. Hence, the desired vaccine coverage was not accomplished, especially among cats from Presidente Prudente.

show abstract

Titulação de anticorpos contra o vírus da raiva em cães, em Campo Grande, MS, na Campanha Anti-Rábica de 2003

Abstract: RESUMO

Cited by 10 publications

References 9 publications

Sero-prevalence of virus neutralizing antibodies for rabies in different groups of dogs following vaccination

Sero-prevalence of virus neutralizing antibodies for rabies in different groups of dogs following vaccination

Low level of the immune response against rabies virus in dogs and cats, a cross-sectional study in sheltered animals, Santander, Colombia

Humoral immune response in dogs and cats vaccinated against rabies in southeastern Brazil

Contact Info

Product

Resources

About