Avaliação da segurança de diferentes doses de suplementos de ácido fólico em mulheres do Brasil

Santos, Quenia dos; Sichieri, Rosely; Marchioni, Dirce Maria Lobo; Verly, Eliseu

doi:10.1590/s0034-8910.2013047004769

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…The paper also discusses that while folate has been associated with decreased risk of certain chronic diseases, there is strong evidence that the excess of nutrients may increase DNA synthesis, stimulating cell proliferation and participate in tumor progression [ 68 ]. Furthermore, because current evidence of the benefits of regular use and risk of excessive consumption of supplements containing folic acid, it is necessary to monitor use of supplements [ 69 , 70 ].…”

Section: Discussionmentioning

confidence: 99%

Folate and Nutrients Involved in the 1-Carbon Cycle in the Pretreatment of Patients for Colorectal Cancer

et al. 2015

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To assess the ingestion of folate and nutrients involved in the 1-carbon cycle in non-treated patients with colorectal adenocarcinoma in a reference center for oncology in southeastern Brazil. In total, 195 new cases with colorectal adenocarcinoma completed a clinical evaluation questionnaire and a Food Frequency Questionnaire (FFQ). Blood samples from 161 patients were drawn for the assessment of serum folate. A moderate correlation was found between serum concentrations of folate, folate intake and the dietary folate equivalent (DFE) of synthetic supplements. Mulatto or black male patients with a primary educational level had a higher intake of dietary folate. Of patients obtaining folate from the diet alone or from dietary supplements, 11.00% and 0.10%, respectively, had intake below the recommended level. Of the patients using dietary supplements, 35% to 50% showed high levels of folic acid intake. There was a prevalence of inadequacy for vitamins B2, B6 and B12, ranging from 12.10% to 20.18%, while 13.76% to 22.55% of patients were likely to have adequate choline intake. The considerable percentage of patients with folate intake above the recommended levels deserves attention because of the harmful effects that this nutrient may have in the presence of established neoplastic lesions.

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Section: Discussionmentioning

confidence: 99%

Folate and Nutrients Involved in the 1-Carbon Cycle in the Pretreatment of Patients for Colorectal Cancer

et al. 2015

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“…Quando ocorre a decisão clínica de suplementar folato, a dose máxima deve levar em conta o total ingerido na dieta diária, e a dose do suplemento. O consumo máximo deve respeitar o limite superior tolerável de ingestão diário de 1000 mcg, sendo valores de suplementação de 400 a 700 mcg diários considerados seguros e mantinham o folato sérico dentro de doses terapêuticas (SANTOS et al, 2013).…”

Section: Resultsunclassified

Folato E Seu Papel Na Depressão

Silva

Pelizzari²,

Linartevichi

2019

FAG J of health

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Introdução: Transtornos depressivos são bastante prevalentes, com grande incapacidade laborativa e social. Podem ter caráter recidivante e persistente ao longo do tempo. A deficiência de folato é potencialmente prevenível e ainda carente de grandes estudos de seu papel na depressão e outros transtornos de saúde mental. Objetivos: Avaliar a associação da deficiência de folato com depressões graves e refratárias ao tratamento, frequentemente descritas com evidências atuais. Metodologia: Os artigos foram selecionados por meio da base de dados PubMed. Resultados: Níveis deficientes de folato são resultantes da baixa ingestão, deficiente absorção intestinal e polimorfismo genético com a forma ineficiente da enzima responsável em converter o folato/ácido fólico em sua forma com atividade biológica, o L-metilfolato. O folato é indispensável na síntese de neurotransmissores ligados aos processos depressivos – serotonina, noradrenalina e dopamina, além participar de forma epigenética na regulação da expressão gênica. Conclusões: apesar da evidência positiva da associação da deficiência de folato com transtornos depressivos, ainda são necessários estudos adicionais para definir quando e quais pacientes podem ser beneficiados com a terapia antidepressiva em associação ao uso de folato.

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“…Survey (INA) indicate that it is almost impossible for women of childbearing age to achieve the recommended additional folate intake only from food sources of natural folate, as these women would need to drastically increase their intake of fruit, vegetables, legumes, and pulses in their diet. Even considering the intake of fortified food products, the recommended level of folate is still not reached in Brazil 32 . Also, our study describes the intake among users and non-users of dietary supplements.…”

Section: Discussionmentioning

confidence: 99%

Diet and supplement assessment in a Brazilian urban population

Sousa

Costa

2021

Rev. saúde pública

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OBJECTIVE: To assess total usual nutrient intakes from foods and dietary supplements by age, sex, physical activity, and nutritional status, and to compare usual nutrient intakes to the Dietary Reference Intakes among non-users and users of dietary supplements in an urban population. METHODS: Cross-sectional population-based survey with 506 adults conducted in the city of Brasília, Brazil, using 24h food recalls. The 24-HR was collected on two nonconsecutive days, for which individuals reported all food, supplements, and beverages consumed in the previous 24 hours. The estimates of mean and the distribution percentiles were adjusted to reflect usual nutrient intake using the Iowa State University method. The prevalence of inadequate micronutrient intake was estimated according to sex using the Estimated Average Requirement (EAR), and values above the Tolerable Upper Intake Level (UL) were also considered. Also, a comparison was made of the total mean usual intake between supplement users and non-users according to BMI and physical activity. RESULTS: The total mean usual dietary intake was significantly higher among users than non-users of dietary supplements (p ≤ 0.02). Dietary supplement use increased intakes of nutrients and decreased prevalence of inadequacy according to sex, with only small (typically < 13%) increases in the population exceeding the Tolerable Upper Intake Level. There was a significant interaction between physical activity and BMI categories with supplement use. CONCLUSIONS: The population that consumes food supplements comprises individuals with more advanced age, female, normal BMI, and physically active. Our findings show that the use of supplements appears beneficial to attain nutrient adequacy. Careful monitoring of intake from food and supplements is recommended, and the statistical methods must be powerful enough to achieve relevant information.

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Avaliação da segurança de diferentes doses de suplementos de ácido fólico em mulheres do Brasil

Cited by 7 publications

References 19 publications

Folate and Nutrients Involved in the 1-Carbon Cycle in the Pretreatment of Patients for Colorectal Cancer

Folate and Nutrients Involved in the 1-Carbon Cycle in the Pretreatment of Patients for Colorectal Cancer

Folato E Seu Papel Na Depressão

Diet and supplement assessment in a Brazilian urban population

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