Comparação histológica entre o osso desmineralizado e polímero de mamona sobre a regeneração óssea

Abstract

Ai m The aim of the present study is to make a histologic analysis the effects of a human demineralized bone matrix and a polyurethane resin derived from the Ricinus communis, on bone regeneration process. Materials and Methods For this, 24 rabbits were submitted to two surgical calvaria bone defects, one on the right and another on the left side of the parietal suture. The animals were divided in two groups. In group I the experimental defect (right side) was treated with a human demineralized bone matrix, while in group II the experimental cavity was treated with the polyurethane resin derived from Ricinus communis. The control defects were filled with the animal's own blood. The animals were slaughtered after subsequent periods of 04, 07 and 15 weeks. Results The histological analysis revealed that all groups (control and experiment), presented increased bone regeneration with time, but this repair was faster in the control group, even showing important decrease in defect thickness. Conclusion Both materials proved to be biologically compatible, however polyurethane was more slowly resorbed presented considerable better results when compared with demineralized bone matrix.

Behavior study of the doped castor bean polymer rod with bioactive glass and hidroxyapatite in mice femur medullary canal

“…These results corroborate the findings of Laureano Filho et al 10 who concluded that the castor bean polymer was little reabsorbed after 15 weeks of research comparing the action of demineralized bone from human origin and the castor bean polymer on bone healing in cavities made in 24 rabbits calvarial. As Pereira et al 22 evaluated through radiographic and histological examinations, the function of the castor bean polymer in bone defects performed in the shaft of rabbits radios and verified at 15, 30, 60 and 120 days of postoperative that the polymer castor bean acted as filler space, minimizing the production of fibrous tissue at the site and showed no signs of resorption in any of the evaluation times.…”

“…The biocompatibility of the castor bean polymer, that is, the acceptance of the organism concerning the implanted material without significant inflammatory focus signals and no foreign body granulomatous reaction was observed in this study in all groups and has been highlighted by several authors after implant in bone defects 10,11 . In this research it was initially noticed the presence moderate to mild inflammatory infiltrate that decreased with time elapsed, but this difference was not statistically significant in Group B.…”

Análisis Histológico del Proceso de Reparación en Defectos Óseos: Reconocimiento de Defectos Críticos

“…El presente estudio es capaz de reportar un proceso de reparación ósea más rápida en defectos rellenados con hueso en partículas al ser comparados con los rellenos con coagulo, lo que está de acuerdo con otros resultados encontrados en la literatura internacional (Haas et al, 2002;Laureano-Filho et al, 2007). Turner (2001) estudió el proceso de reparación ósea en diferentes modelos animales (primates, canes, gatos, ratones, conejos y minicerdos), observando que la velocidad de la reparación ósea en el humano era más próxima al de los perros con una relación de 1:3 (hombre: can).…”

Avaliação da interação biológica entre polímero de poliuretana de mamona acrescido de carbonato de cálcio e tecido ósseo de equinos

“…Além disso, é biocompatível quando em contato com culturas de células e tecido conjuntivo, e quando empregada sob a forma de implantes ou enxertos (COSTA et al, 1997;FRASCINO, 1998;ARA, 1999;BONINI, 1999;BONINI et al, 2002a, b;LAUREANO FILHO et al, 2007;CELESTE et al, 2010), em leitos subperiósticos (PURICELLI et al, 1999) ou em tecido ósseo (CARVALHO et al, 1997;KONIG JR et al, 1999;RAMALHO, 1999;GARCIA JR, 2000;CAVALIERI;SÁ-LIMA;GOMES, 2001;INÁCIO et al, 2002;BRANDT;LIMA, 2002;DEL CARLO et al, 2003;LEONEL et al, 2003;RIBEIRO, 2003;LEONEL et al, 2004;POPAK et al, 2004;SARAN, 2006). De acordo com Ignácio et al (2002), por ser ácido graxo, tem comportamento de lípede, permitindo sua degradação por mecanismo de lipólise.…”

“…Diante da necessidade de se encontrar substituto ósseo para utilização em equinos, agregando as qualidades de um bom biomaterial sem que o custo inviabilizasse seu uso, foi utilizado o polímero de poliuretana de mamona, material atualmente comercializado no mercado nacional e internacional, com características conhecidas e estudadas em outras espécies (IGNÁCIO et al, 2002;DEL CARLO et al, 2003;BOLSON et al, 2005;SARAN et al, 2006;CELESTE et al, 2010). Tendo como fator diferencial realidade financeira da ortopedia de equinos, no mercado nacional, critério de escolha para realização do estudo que também foi considerado por Laureano Filho et al (2007) para justificar a pesquisa deste biomaterial para uso futuro em casos clínicos na medicina.…”