Aspectos do diagnóstico na Síndrome de Sjögren

Liquidato, Bianca Maria; Filho, Ivo Bussoloti; Camargo, Ana Cristina Kfouri; Soler, Rita de Cássia

doi:10.1590/s0034-72992002000300011

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…Classificada como doença autoimune das glândulas exócrinas, envolve particularmente as glândulas salivares e lacrimais (Liquidato et al, 2002).…”

Section: Lista De Abreviaturas E Siglasunclassified

“…A Síndrome de Sjögren (SS) é a segunda doença reumática autoimune mais comum, superada apenas pela artrite reumatoide (Fox et al, 2000). Classificada como doença autoimune das glândulas exócrinas, envolve particularmente as glândulas salivares e lacrimais (Liquidato et al, 2002) É uma doença de progressão lenta que afeta principalmente mulheres, em uma proporção de 9:1, entre a quinta e sétima décadas de vida. Existem poucos estudos direcionados para se estimar a prevalência da SS e os até hoje realizados mostram ampla variação de 0,1 a 4,8%.…”

Section: Aspectos Geraisunclassified

“…A SS pode ser vista isoladamente (SS primária) ou em associação com outras doenças autoimunes (SS secundária), principalmente lúpus e artrite reumatoide (Vitali et al, 2002). Pelo amplo quadro clínico que a SS apresenta, podendo manifestar-se apenas com diminuição do lacrimejamento e xerostomia ou, concomitantemente, com alterações articulares, pulmonares ou renais, a abordagem diagnóstica é bastante complicada (Liquidato et al, 2002). (Dalavanga et al, 1986;Xanthou et al, 1999).…”

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Prevalência da Síndrome de Sjögren em infectados pelo HTLV em São Paulo

Vale¹

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Vale DA. Prevalence of Sjögren's Syndrome among HTLV-infected individuals in São Paulo [dissertation]. São Paulo: Universidade de São Paulo, Faculdade de Odontologia; 2013. Versão corrigida. HTLV-1 (human T-cell lymphotropic virus type 1) was the first human retrovirus identified. It is proven to be the etiological agent of adult T-cell leukemia/lymphoma (ATLL) and of a neurological disease known as HTLV-1 associated myelopathy or tropical spastic paraparesis (HAM/TSP). However, there is the evidence that the virus could be related to several other systemic manifestations. Sjögren's Syndrome (SS) is one of the disorders that have been associated with HTLV-1. Although HTLV infection is known to be endemic in Brazil, there is no information about this association in Brazilian population. This study proposes to investigate the prevalence of SS among patients infected with HTLV and the prevalence of HTLV among patients diagnosed with SS. Serological tests for HTLV were performed in 50 patients from Irmandade da Santa Casa de Misericórdia de São Paulo (ISCMSP) with complaints compatible with the SS (group 1). At Institute of Infectious Diseases Emilio Ribas (IIER), 129 HTLV+ patients were evaluated and the diagnostic process for SS was performed (group 2). None of the patients in group 1 was positive for HTLV. In group 2, 46 (35.7%) reported any degree of xerostomia, 18 (13.95%) had xerophtalmia, hyposalivation was present in 8 (6.2%) patients and decrease in tear secretion, in only one patient (0.77%) the auto-antibodies was positive (Anti-SSB). Incisional biopsies of labial minor salivary glands were executed in 5 patients in group 2. Only 2 HTLV+ patients (1.55%) have fulfilled the classification criteria for SS. SS proved to be three times more prevalent in HTLV patients from IIER than in patients who sought care in the service of Otorhinolaryngology at ISCMSP.

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“…Classificada como doença autoimune das glândulas exócrinas, envolve particularmente as glândulas salivares e lacrimais (Liquidato et al, 2002).…”

Section: Lista De Abreviaturas E Siglasunclassified

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Prevalência da Síndrome de Sjögren em infectados pelo HTLV em São Paulo

Vale¹

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“…A SS é uma exocrinopatia de origem autoimune que afeta particularmente as glândulas salivares e lacrimais causando variados graus de xerostomia, hipossalivação e queratoconjuntivite seca (Liquidato et al, 2002;Vitali et al, 2002).…”

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Detecção de proteínas e partículas virais do HTLV-1 em glândulas salivares de pacientes com Síndrome de Sjögren e de infectados pelo HTLV-1

Vale¹

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Vale DA. Detection of HTLV-1 viral proteins and particles in the salivary glands of patients with Sjögren's Syndrome and patients infected with HTLV-1 [thesis]. São Paulo: Universidade de São Paulo, Faculdade de Odontologia; 2017. Versão original. Human T-cell lymphotropic virus type I (HTLV-1) was the first human retrovirus to be discovered. HTLV-1 has the ability to activate and generate an intense inflammatory response, which can lead to changes in several tissues that mimic an autoimmune disease Of the complex of diseases associated with HTLV-1, Sjögren's Syndrome (SS) is among the most studied. The aim of this study is to investigate the presence of HTLV-1 in the minor salivary glands of patients infected with this retrovirus and to compare the morphological alterations in the salivary glands of patients with HTLV-1 and patients with SS uninfected. Minor salivary gland samples were obtained from 14 HTLV + patients with dry syndrome (study group) and 5 patients diagnosed with SS and HTLV negative (control group). In the study group, the inflammatory infiltrate was mainly composed of CD4+ T lymphocytes, in the control group the majority population was of CD20+ B lymphocytes. Morphological changes such as fibrosis and adipose tissue infiltration were more common in the study group, the difference was statistically significant (p = 0.038 and 0.033, respectively). The HTLV-1 tax and/or rex genes were detected by PCR in 11 (78.57%) patients of the study group, but 4 (80%) samples from the control group were also positive. HTLV-1 shows signs of being present in the salivary glands of individuals with dry syndrome however, HTLV-1+ patients present morphological alterations in different patterns from those observed in SS patients, denoting a probable difference in the immunological activation process.

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