Prevalência da Síndrome de Sjögren em infectados pelo HTLV em São Paulo

Abstract

Vale DA. Prevalence of Sjögren's Syndrome among HTLV-infected individuals in São Paulo [dissertation]. São Paulo: Universidade de São Paulo, Faculdade de Odontologia; 2013. Versão corrigida. HTLV-1 (human T-cell lymphotropic virus type 1) was the first human retrovirus identified. It is proven to be the etiological agent of adult T-cell leukemia/lymphoma (ATLL) and of a neurological disease known as HTLV-1 associated myelopathy or tropical spastic paraparesis (HAM/TSP). However, there is the evidence that the virus could be related to several other systemic manifestations. Sjögren's Syndrome (SS) is one of the disorders that have been associated with HTLV-1. Although HTLV infection is known to be endemic in Brazil, there is no information about this association in Brazilian population. This study proposes to investigate the prevalence of SS among patients infected with HTLV and the prevalence of HTLV among patients diagnosed with SS. Serological tests for HTLV were performed in 50 patients from Irmandade da Santa Casa de Misericórdia de São Paulo (ISCMSP) with complaints compatible with the SS (group 1). At Institute of Infectious Diseases Emilio Ribas (IIER), 129 HTLV+ patients were evaluated and the diagnostic process for SS was performed (group 2). None of the patients in group 1 was positive for HTLV. In group 2, 46 (35.7%) reported any degree of xerostomia, 18 (13.95%) had xerophtalmia, hyposalivation was present in 8 (6.2%) patients and decrease in tear secretion, in only one patient (0.77%) the auto-antibodies was positive (Anti-SSB). Incisional biopsies of labial minor salivary glands were executed in 5 patients in group 2. Only 2 HTLV+ patients (1.55%) have fulfilled the classification criteria for SS. SS proved to be three times more prevalent in HTLV patients from IIER than in patients who sought care in the service of Otorhinolaryngology at ISCMSP.

O Contexto Panorâmico Do Segundo Testamento

“…O vale de Jezreel conhecido por suas montanhas e vales verdes predominantes em sua extensão, "[...] é delimitado ao sul pelos planaltos de Samaria e pelo monte Gilboa, ao norte pela Baixa Galileia, ao oeste pela cordilheira do monte Carmelo e ao leste pelo vale do Jordão" (LAGES, 2012). Assim, a topografia nos mostra que "[...] estando no norte do país, o vale é servido por chuvas mais que o Negueve, ao sul, o que favorece a agricultura" (CAFETORAH, 2019;LAND OF THE BIBLE, 2018;BÍBLIA ANOTADA,2020).…”