Otoproteção das células ciliadas auditivas contra a ototoxicidade da amicacina

Oliveira, José Antônio Apparecido de; Canedo, D. M.; Rossato, Maria

doi:10.1590/s0034-72992002000100002

Cited by 30 publications

(38 citation statements)

References 18 publications

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“…The most common type of OHC injury found on the analysis was the absence of sterocilia, followed by the cilia distortion with derangement of "W" pattern. This finding coincides with other publications 11,15 .…”

Section: Discussionsupporting

confidence: 94%

“…In Otology, the guinea pigs are largely used as experimental animals because of its easy handling, good cochlear dissection and manipulation as well as the facility to infuse anesthetic drugs and experimental drugs, intraperitoneally or intramuscularly 8,11,14 . The most common type of OHC injury found on the analysis was the absence of sterocilia, followed by the cilia distortion with derangement of "W" pattern.…”

Section: Discussionmentioning

confidence: 99%

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Otoproteção em cobaias expostas a agrotóxico e ginkgo biloba

Finkler¹,

Silveira²,

Munaro³

et al. 2012

Braz. j. otorhinolaryngol.

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Pesticides are widely used in agriculture, despite the risk of hearing loss related to the exposure to their chemical components. This study looks into protective drugs to counteract the ototoxicity of pesticides. Objective This study aims to analyze the effect ginkgo biloba extract may have in protecting against possible cochlear damage caused by organophosphate pesticides (methamidophos). Anatomic changes are assessed through surface and electron microscopy. Materials and Methods This is a prospective experimental study. Twenty-one guinea pigs were given saline solution, pesticide, and ginkgo biloba alone or combined for seven consecutive days. Then their cochleas were removed and examined in a scanning electron microscope. Results Pesticide-exposed guinea pigs had morphological alterations in their cochleas and injuries in the three turns analyzed through electron microscopy. Injury intensity varied according to the dosages of the agents given to the test subjects. Guinea pigs treated with pesticide and ginkgo biloba maintained the architecture of their outer hair cells in all cochlear turns. Conclusion The antioxidant properties found in the ginkgo biloba extract protected guinea pigs from pesticide ototoxicity.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Otoproteção em cobaias expostas a agrotóxico e ginkgo biloba

Finkler¹,

Silveira²,

Munaro³

et al. 2012

Braz. j. otorhinolaryngol.

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“…Although it is a marker of neural progenitor cells, as demonstrated for mice tissues (Chao et al 2013), it is probable that these neural cell lineages likely went lost during our undifferentiated cell cultivation. In contrast, ciliated, sensory cells and pluripotent stem cells were maintained, indicated by the presence of myosin VIIa and tubulin expression (Dabdoub et al 2008;Banerjee et al 2008;Piatto et al 2005;Oliveira et al 2002). In addition, the phenotypic characterization revealed the presence of the pluripotency markers Oct-4 and Sox-2, mesenchymal stem cell markers, i.e.…”

Section: Discussionmentioning

confidence: 99%

Cochlear epithelial of dog fetuses: a new source of multipotent stem cells

et al. 2017

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Hearing loss caused by the damage of cochlea sensory cells or neurons is a common human disease, but also affects dogs and other animals. To test their progenitor nature as potential value for future therapies, we characterized cells derived from the cochlear epithelium in dog fetuses. In total, 8 fetuses of 35-40 days of gestation, derived from castration campaigns, were investigated. Cells were analysed by the MTT colorimetric assay and in regard to cell cycle, differentiation capacities, immunophenotypes and qPCR analysis. In culture, cells had a fibroblast-like morphology. Phenotypic immunocharacterization showed positive staining for mesenchymal stem cell and pluripotency markers and were negative for hematopoietic cell markers. Cells possessed differentiation capacity for the three main cell lineages: osteogenic, adipogenic and chondrogenic, altogether indicating their nature as mesenchymal stem cells. Thus, cells derived from fetal cochlear tissues indeed may provide valuable sources of progenitor cells for cell therapy of canine deafness and other diseases.

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“…16 As emissões otoacústicas são testes de grande valia clínica, por mapear a função das células ciliadas externas ao longo do órgão de Córti, possibilitando a identificação do local onde estas se encontram lesadas. É um teste bastante útil para monitorar os estados de riscos para a audição.…”

Section: Discussionunclassified

Emissões otoacústicas x Cisplatina: detecção precoce da ototoxicidade em pacientes oncológicos

Zocoli

Reichow²,

Zocoli

2003

Rev. Bras. Otorrinolaringol.

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Est udos mostram que existem numerosas substâncias reconhecidas como potencialmente ototóxicas e entre as principais, na classe dos medicamentos, destacam-se os quimioterápicos. Objetivo: o objetivo deste trabalho foi realizar um estudo da ototoxicidade através das emissões otoacústicas evocadas -produto de distorção (EOA-PD), pré e pós-aplicação do quimioterápico Cisplatina, em indivíduos adultos, moradores da cidade de Blumenau/SC. Forma de Estudo: Prospectivo clínico. Material e Método: Foram estudados 11 indivíduos com patologia oncológica, idade variando entre 29 e 73 anos, através das emissões otoacústicas evocadas -produto de distorção, prévia e posteriormente à aplicação da Cisplatina, utilizando-se o equipamento Madsen Cappela acoplado ao Notebook Toshiba Satélite. Resultados: Os resultados não mostraram mudanças significativas nas respostas das EOA-PD nas freqüências de 2, 3 e 4 kHz, porém, em 1 e 6 kHz, ocorreram alterações na sensibilidade auditiva, após a aplicação da Cisplatina. St udies show that there are numerous substances known as potentially ototoxic and among the main ones in the medicine classes, stands out the chemotherapeutics. Aim: The objective of this work was to achieve a study of the ototoxicity through otoacoustic emissions -product of distortion (EOA -PD), pre and post-application of the chemotherapeutic Cisplatin, in adults individuals, residents of the city of Blumenau/SC. Study Form: Clinic prospective. Material and Method: There were 11 individuals studied with oncologic pathology, age between 29 and 73 years old, through the otoacoustic emissions -product of distortion, previous and subsequently to the Cisplatin application, using the Madsen Cappela equipment coupled to the notebook Toshiba satellite computer. Results: The results didn't show significant changes on the answers of the EOA -PD on the frequencies of 2, 3 and 4 kHz, however, in 1 and 6 kHz, alterations occurred on the hearing sensitivity after the Cisplatin application. Ruysdael ORIGINAL ARTICLE ARTIGO ORIGINALRev Bras Otorrinolaringol.

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Otoproteção das células ciliadas auditivas contra a ototoxicidade da amicacina

Abstract: Palavras-chave: ototoxicidade, antibióticos aminoglicosídeos, amicacina, autodefesa.

Cited by 30 publications

References 18 publications

Otoproteção em cobaias expostas a agrotóxico e ginkgo biloba

Otoproteção em cobaias expostas a agrotóxico e ginkgo biloba

Cochlear epithelial of dog fetuses: a new source of multipotent stem cells

Emissões otoacústicas x Cisplatina: detecção precoce da ototoxicidade em pacientes oncológicos

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