Síndrome oculoglandular de Parinaud causada por esporotricose

Ribeiro, Alexandre Sampaio de Abreu; Bisol, Tiago; Menezes, Marcela Sant'Ana

doi:10.1590/s0034-72802010000500008

Cited by 15 publications

(7 citation statements)

References 24 publications

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“…Distinct ocular presentations of sporotrichosis such as conjunctivitis, 30,31 dacryocystitis, 32 uveitis, choroiditis 27,28 and retro‐bulbar lesions 24 have been reported in human patients. Granulomatous conjunctivitis is the most common clinical manifestation of ocular sporotrichosis 31 .…”

Section: Discussionmentioning

confidence: 99%

Primary conjunctival sporotrichosis in three cats from Northeastern Brazil

Spinelli¹,

Bezerra²,

Souza

et al. 2021

Veterinary Ophthalmology

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Introduction Classically, sporotrichosis occurs as a chronic granulomatous lymphocutaneous infection. The extracutaneous form is uncommon and may affect the eye without cutaneous involvement. The most frequent form of ocular sporotrichosis reported in humans is a granulomatous conjunctivitis. There are no previous reports on primary ocular sporotrichosis in cats. Procedures Three mixed breed cats rescued from shelters were referred by the veterinarian for ophthalmic evaluation with a complaint of conjunctivitis nonresponsive to treatment with no evidence of skin disease or systemic disease. Complete ophthalmic examination, conjunctival cytology, and microbiological analysis were performed. Results Ophthalmic examinations revealed epiphora, purulent ocular discharge, conjunctival hyperemia, and a mass in the palpebral conjunctiva. Conjunctival cytology revealed segmented and degenerated neutrophils, conjunctival epithelial cells, and an abundant number of round and oval cells compatible with Sporothrix spp. Microbiological culture was performed and confirmed the presence of fungi from the Sporothrix schenckii complex. All animals were treated with oral itraconazole; two animals received topical itraconazole in association with oral treatment. Case 1 was refractory to treatment, and iodate potassium was combined with itraconazole therapy without resolution at the time of this publication. Cases 2 and 3 had complete resolution of conjunctival lesions with four months of oral and topical itraconazole therapy. Conclusion Conjunctival sporotrichosis should be considered as a differential diagnosis of conjunctivitis in cats from endemic regions. Conjunctival cytology is an important tool that can aid early diagnosis.

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Section: Discussionmentioning

confidence: 99%

Primary conjunctival sporotrichosis in three cats from Northeastern Brazil

Spinelli¹,

Bezerra²,

Souza

et al. 2021

Veterinary Ophthalmology

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“…POS occurs when the patient has granulomatous conjunctivitis and pre-auricular or submandibular ipsilateral lymphadenopathy, as observed in patients 2 and 3. 8 Acute dacryocystitis is an inflammation of the lacrimal sac with infiltration, swelling, and induration observed in the medial canthal ligament of the eye and can progress to become chronic. 9 Bulbar conjunctivitis is when this mucosa is infiltrated, with pink coloration and hiperemia.…”

Section: Discussionmentioning

confidence: 99%

Ocular sporotrichosis: A frequently misdiagnosed cause of granulomatous conjunctivitis in epidemic areas

Yamagata

Rudolph

Nobre

et al. 2017

American Journal of Ophthalmology Case Reports

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PurposeSporotrichosis is a subcutaneous mycosis caused by Sporothrix sp., a dimorphic fungus. Although the cutaneous form is the most frequent form, the ocular presentation has been increasingly diagnosed in epidemic areas. We describe three cases of ocular sporotrichosis with the involvement of the ocular adnexa due to autoinoculation without trauma with successful antifungal treatment.ObservationsPatient 1: A 68-year-old woman presented with granulomatous conjunctivitis of the right eye with an ulcerated nodule on the right temporal region for 5 months. Patient 2: A 46-year-old woman with conjunctival hyperemia of the left eye with associated periorbital edema and erythema for the past 4 months was referred to the Dermatology Department due to an ulcerated nodule on the left malar region. Patient 3: A 14-year-old boy presented to the emergency department with inferior palpebral edema with a 5-day evolution. Specimens were obtained from the lesions of the three patients, and the cultures were positive for Sporothrix sp. The three cases were diagnosed as ocular sporotrichosis and were successfully treated with itraconazole (200–400 mg/d). Two of the three patients developed sequelae such as conjunctival fibrosis and symblepharon.Conclusions and importanceWe emphasize the importance of the ophthalmologist being familiar with the diagnosis and management of this rare and frequently misdiagnosed form of sporotrichosis.

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“…A recent Brazilian guideline advocates that itraconazole is the drug of election for feline sporotrichosis treatment (Gremião et al, 2020). Interestingly, a parallel can be drawn between the clinical presentation of this cat's eye, pinna, and regional lymph nodes with the Parinaud's Oculoglandular Syndrome, a relatively frequent sporotrichosis presentation in humans (Ribeiro et al, 2010(Ribeiro et al, , 2020. Whether this similarity can be related to S. brasiliensis pathophysiology in both hosts has yet to be investigated.…”

Section: Discussionmentioning

confidence: 99%

Ocular lesions in a domestic feline:

Mothé

Reis

Melivilu

et al. 2021

Braz. J. Vet. Res. Anim. Sci.

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Sporotrichosis is a dermatozoonosis, caused by dimorphic pathogenic fungi of the genus Sporothrix. Although Sporothrix brasiliensis is the most frequent and pathogenic species identified from the Brazilian sporotrichosis hyperendemic, to the best of our knowledge this is the first report of its molecular diagnosis from a cat with ocular lesions. A 3-month old female, domestic feline presented an ocular manifestation with granuloma in the lower-left palpebral conjunctiva, in addition to mucocutaneous lesions in varied locations throughout the body. Samples were collected for subsequent cytopathology, fungal culture, serology, and molecular genotyping. Itraconazole was prescribed for the treatment of sporotrichosis and the animal was considered clinically cured at the end of 5 months of treatment and discharged. S. brasiliensis cat interactions can manifest with a multitude of clinical forms that resemble either infectious or noninfectious diseases. Both the need for meticulous cat physical evaluation by a veterinarian followed by accurate laboratory diagnosis are key Public Health measures in the Brazilian sporotrichosis hyperendemic area.

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Síndrome oculoglandular de Parinaud causada por esporotricose

Cited by 15 publications

References 24 publications

Primary conjunctival sporotrichosis in three cats from Northeastern Brazil

Primary conjunctival sporotrichosis in three cats from Northeastern Brazil

Ocular sporotrichosis: A frequently misdiagnosed cause of granulomatous conjunctivitis in epidemic areas

Ocular lesions in a domestic feline:

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