Sporotrichosis zoonotic transmission by cats has obtained hyperendemic magnitude in Rio de Janeiro, Brazil. Atypical cases, relapses, and reinfections as well as reduced diagnostic sensitivity of conventional methods have been reported. Previously, the anti-SsCBF enzyme-linked immunosorbent assay (ELISA) test was shown to be useful as a diagnostic tool for human sporotrichosis. Effective diagnosis and treatment are critical to interrupt the chain of transmission of this major pathogen in Brazilian Public Health. To evaluate its applicability for feline sporotrichosis diagnosis and/or therapeutic follow-up, 15 domestic cats from Rio de Janeiro were clinically and laboratory monitored by cytopathology, culture, Sporothrix genotyping, and anti-SsCBF IgG levels. Subsequently, animals were divided into satisfactory and non-satisfactory therapeutic responders. Averages of antibody serum levels obtained for diagnosis (first consultation) compared with the levels found after follow-up (last consultation) were significantly different in both groups (p = 0.0002 and p = 0.038, respectively). We conclude that the SsCBF ELISA test can predict feline sporotrichosis therapeutic responses even for animals with distinct clinical evolutions.
Sporotrichosis is a dermatozoonosis, caused by dimorphic pathogenic fungi of the genus Sporothrix. Although Sporothrix brasiliensis is the most frequent and pathogenic species identified from the Brazilian sporotrichosis hyperendemic, to the best of our knowledge this is the first report of its molecular diagnosis from a cat with ocular lesions. A 3-month old female, domestic feline presented an ocular manifestation with granuloma in the lower-left palpebral conjunctiva, in addition to mucocutaneous lesions in varied locations throughout the body. Samples were collected for subsequent cytopathology, fungal culture, serology, and molecular genotyping. Itraconazole was prescribed for the treatment of sporotrichosis and the animal was considered clinically cured at the end of 5 months of treatment and discharged. S. brasiliensis cat interactions can manifest with a multitude of clinical forms that resemble either infectious or noninfectious diseases. Both the need for meticulous cat physical evaluation by a veterinarian followed by accurate laboratory diagnosis are key Public Health measures in the Brazilian sporotrichosis hyperendemic area.
O adenocarcinoma do ducto apócrino é um tipo de neoplasia da glândula sudorípara pouco relatado. Neste trabalho, é descrito o caso de um cão, com seis anos de idade, atendido no Hospital Universitário de Medicina Veterinária da Universidade Federal Fluminense (HUVET-UFF) com lesões ulceradas e circulares na pele do pescoço, membro torácico e hemitórax direitos. Anteriormente, em outra clínica, o cão recebeu o diagnóstico errado de esporotricose, realizado por meio apenas de citopatologia e foi submetido a terapêutica padrão com antifúngico que não resultou em qualquer melhora. Já no HUVET-UFF, exames complementares foram realizados, dentre os quais a biópsia das lesões para cultura fúngica e histopatologia. A cultura resultou negativa para esporotricose e o exame histopatológico descreveu as alterações caracterizando a enfermidade não como doença fúngica, como fora anteriormente diagnosticado, mas como adenocarcinoma apócrino ductal micropapilífero, uma neoplasia maligna, já em estágio avançado de desenvolvimento e que rapidamente levou o paciente à óbito. Portanto, esse trabalho objetivou relatar a ocorrência desse distinto padrão de adenocarcinoma do ducto apócrino em cão que inicialmente se assemelhou à manifestação clínica de esporotricose e que, se tivesse sido diagnosticado corretamente e tratado sem morosidade poderia ter resultado em maior sobrevida para o paciente.
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