Uso da papaína na úlcera plantar

Aim:A comparative evaluation of the antimicrobial activity of natural extracts of Morinda citrifolia, papain, and aloe vera (all in gel formulations), 2% chlorhexidine gel and calcium hydroxide, against Enterococcus faecalis—an in vitro study.Materials and Methods:The antimicrobial efficacy was assessed in vitro using dentin shavings collected at 2 depths of 200 and 400 μm. The total colony forming units at the end of 1, 3, and 5 days were assessed.Results:The overall percentage inhibition of bacterial growth (200 and 400 μm depth) was 100% with chlorhexidine gel. This was followed by M. citrifolia gel (86.02%), which showed better antimicrobial efficacy as compared with aloe vera gel (78.9%), papain gel (67.3%), and calcium hydroxide (64.3%). There was no statistical difference between data at 200 and 400 μm depth.Conclusion:Chlorhexidine gel showed the maximum antimicrobial activity against E. faecalis, whereas calcium hydroxide showed the least. Among the natural intracanal medicaments, M. citrifolia gel consistently exhibited good inhibition up to the 5th day followed by aloe vera gel and papain gel.

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“…This was probably due to proteolytic cysteine enzyme present in papain, which exhibits antibacterial and anti-inflammatory properties. [11]…”

Section: Discussionmentioning

confidence: 99%

“…[11] Papain acts as a debris-removing agent. It acts only on affected tissues, which lack the α1-antitrypsine plasmatic antiprotease that inhibits proteolysis in healthy tissues.…”

Section: Introductionmentioning

confidence: 99%

Comparative evaluation of the antimicrobial activity of natural extracts of Morinda citrifolia, papain and aloe vera (all in gel formulation), 2% chlorhexidine gel and calcium hydroxide, against Enterococcus faecalis: An in vitro study

Bhardwaj¹,

Ballal

Velmurugan

2012

J Conserv Dent

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“…A papaína apresenta bons resultados como desbridante e acelerador do processo de cicatrização, com formação de tecido de granulação, com baixo custo em relação a coberturas industrializadas (13)(14)18) .…”

Section: Categoria 1: Indicações E Contra-indicações Ao Uso Da Papaínaunclassified

“…A fim de conservar a atividade proteolítica da papaína, em três estudos (3,(10)(11) foi evidenciado que sua diluição em pó foi realizada no momento da aplicação e utilizada logo em seguida. Dois estudos referem ter deixado a solução para uso por 12 horas em ar ambiente (13,22) . Atualmente, foi demonstrado que essa exposição prolongada causa inativação enzimática do produto com perda da atividade proteolítica (28) .…”

Section: Categoria 2: Apresentações Da Papaínaunclassified

Uso e efetividade da papaína no processo de cicatrização de feridas: uma revisão sistemática

Leite¹,

Oliveira²,

Soares³

et al. 2012

Rev. Gaúcha Enferm.

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Trata-se de uma revisão sistemática, cujo objetivo é analisar as evidências sobre o uso da papaína na cicatrização de feridas. Foi realizado levantamento bibliográfico manual e eletrônico nas bases de dados: LILACS; COCHRANE; IBECS; MEDLINE via Pubmed e CINAHL, utilizando os seguintes termos como descritores e como palavras: Carica; Papaína; e Cicatrização, período de 1987 a 2010. Os resultados apontaram predomínio de estudos descritivos, exploratórios, estudos de caso e relatos de caso, apenas um ensaio clínico randomizado e controlado. Os resultados também evidenciaram que a papaína é usada em feridas de diversas etiologias e em todas as fases da cicatrização, sem contraindicações específicas, sendo efetiva e segura, embora haja relatos de ardência e dor. Conclui-se que este estudo contribuiu para demonstrar o uso da papaína nesse período, como fonte de consulta, além de apontar para necessidade de pesquisas com maior rigor metodológico, que proporcionem evidências fortes do seu uso e recomendação.

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“…The product is a gel based on papain, a proteolytic cisteine enzyme which presents antibacterial and anti-inflammatory properties. 5,6 Papain acts as a debris-removing agent, with no harmful effect on sound tissues because of the enzyme's specificity. It acts only on affected tissues, which lack the α1-antitripsine plasmatic antiprotease that inhibits proteolysis in healthy tissues.…”

Section: Introductionmentioning

confidence: 99%

Papain-based gel for biochemical caries removal: influence on microtensile bond strength to dentin

et al. 2008

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This study investigated the influence of a papain-based gel (Papacárie) for chemo-mechanical caries removal on bond strength to dentin. Human molars were assigned to the following groups: Group 1: sound teeth were flattened to expose dentin; Group 2: after flattening of surfaces, the papain-based gel was applied on the sound dentin; Group 3: overlying enamel from carious teeth was removed and mechanical excavation of dentin was conducted; Group 4: chemo-mechanical excavation of carious dentin was conducted using the papain-based gel. The Prime&Bond NT or Clearfil SE Bond adhesive systems were used for restorative procedures. A microtensile bond strength test was performed, and the modes of failure were determined under SEM. The data were submitted to two-way ANOVA and Tukey's test (p < or = 0.05). No significant differences were observed between the sound dentin groups. For both excavation methods, Clearfil presented a significantly higher bond strength than Prime&Bond NT. Also, for Clearfil, the mechanically excavated samples disclosed a significantly higher bond strength than the chemo-mechanically ones. For Prime&Bond NT, no significant differences were detected between the excavation methods. Predominance of mixed failures for the sound substrate and of adhesive failures for the carious dentin one was detected. The bond strength to carious dentin of the self-etching system was negatively affected by chemo-mechanical excavation using the papain-based gel.

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Uso da papaína na úlcera plantar

Cited by 8 publications

References 1 publication

Comparative evaluation of the antimicrobial activity of natural extracts of Morinda citrifolia, papain and aloe vera (all in gel formulation), 2% chlorhexidine gel and calcium hydroxide, against Enterococcus faecalis: An in vitro study

Comparative evaluation of the antimicrobial activity of natural extracts of Morinda citrifolia, papain and aloe vera (all in gel formulation), 2% chlorhexidine gel and calcium hydroxide, against Enterococcus faecalis: An in vitro study

Uso e efetividade da papaína no processo de cicatrização de feridas: uma revisão sistemática

Papain-based gel for biochemical caries removal: influence on microtensile bond strength to dentin

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