Particularidades imunológicas do pré-termo extremo: um desafio para a prevenção da sepse hospitalar

Mussi-Pinhata, Marisa Márcia; Rego, Maria Aparecida do Carmo

doi:10.1590/s0021-75572005000200008

Cited by 35 publications

(26 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Os fatores relacionados ao seu aparecimento no recém-nascido (RN), especialmente no pré-termo, são a necessidade de utilização de procedimentos invasivos, associados à imaturidade imunológica [3][4][5] .…”

Section: Introductionunclassified

Accuracy of white blood cell count, C-reactive protein, interleukin-6 and tumor necrosis factor alpha for diagnosing late neonatal sepsis

Caldas¹,

Marba²,

Blotta³

et al. 2008

J Pediatr (Rio J)

View full text Add to dashboard Cite

ARTIGO ORIGINALAccuracy of white blood cell count, C-reactive protein, interleukin-6 and tumor necrosis factor alpha for diagnosing late neonatal sepsis Acurácia diagnóstica do leucograma, Resultados: Estudaram-se 82 crianças, sendo 42 no grupo SC, 16 no SP e 24 NI. Nos três momentos, as medianas da PCR e da IL-6 mostraram-se significativamente mais elevadas nos grupos SC e SP, e as do TNF-α alteraram-se apenas no grupo SC. Os índices diagnósticos da PCR foram elevados nos três momentos e com acurácia superior a do leucograma e semelhante a da IL-6 e a do TNF-α em suas primeiras medidas. Entre as citocinas, não houve diferença estatística entre elas, nem em relação ao leucograma. A associação dos testes não aumentou a capacidade diagnóstica, exceto na combinação entre leucograma e PCR2 e na dosagem seriada de PCR. Conclusões:A PCR e o leucograma mostram-se úteis no diagnóstico de sepse neonatal tardia e comparáveis à IL-6 e ao TNF-α. A acurácia aumentou com a associação PCR-leucograma e a dosagem seriada da PCR.J Pediatr (Rio J). 2008;84(6):536-542: Recém-nascido, sepse, proteína C-reativa, interleucina-6, fator de necrose tumoral, citocina, mediadores da inflamação. AbstractObjective: To evaluate the diagnostic value for late neonatal sepsis of white blood cell count (WBC) and assays for C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α), in isolation and in conjunction.Methods: This was a diagnostic test validation study. Chemiluminescence was used to assay CRP, IL-6 and TNF-α at the time of clinical suspicion and again after 24 and 48 hours, whereas the WBC was performed only once, at the time of suspicion. Patients were classified into three groups based on clinical progress and culture results: confirmed sepsis (CS), probable sepsis (PS), and not infected (NI). Statistical analysis was performed using the Wilcoxon and chi-square tests and Friedman analysis of variance; cutoffs were defined by plotting receiver operator characteristic curves. Results:The total study sample comprised 82 children, 42 of whom were classed as CS, 16 as PS and 24 as NI. At all three test times, the medians for CRP and IL-6 were significantly more elevated in the CS and PS groups, while the medians for TNF-α were abnormal only in the CS group. The CRP test had elevated indices of diagnostic utility at all three test times, better accuracy than the WBC and similar accuracy to the first IL-6 and TNF-α assays. There was no statistical difference between the cytokines, nor between them and the WBC. Combining tests did not increase diagnostic power, with the exception of the combination of WBC with CRP2 and when the sequential CRP assays were combined. Conclusions:Both CRP and WBC were useful for the diagnosis of late neonatal sepsis and comparable with IL-6 and TNF-α. Accuracy increased when CRP and WBC were combined and when sequential CRP assay results were used.J Pediatr (Rio J). 2008;84(6):536-542: Neonate, sepsis, C-reactive protein, interleukin-6, tumor necrosis factor, cytokine, inflammatory...

show abstract

Section: Introductionunclassified

Accuracy of white blood cell count, C-reactive protein, interleukin-6 and tumor necrosis factor alpha for diagnosing late neonatal sepsis

Caldas¹,

Marba²,

Blotta³

et al. 2008

J Pediatr (Rio J)

View full text Add to dashboard Cite

show abstract

“…São representantes de um universo seleto, que por si só advém com suas particularidades ímpares, desta forma atraem a atenção dos profissionais de saúde, por apresentarem uma inabilidade em se adequarem à vida extrauterina. Rego (2005) possuem diversos fatores que facilitam a invasão bacteriana e a ocorrência de sepse neonatal.…”

Section: Considerações Iniciaisunclassified

Caracterização dos Recém-Nascidos Internados em Unidades de Terapia Intensiva

Freitas¹,

Sousa²,

Cabral³

et al. 2018

IDonline

View full text Add to dashboard Cite

Resumo: Prestar cuidados ao ser humano hospitalizado requer muita competência e segurança e negligenciar essa assistência possibilita erros imensuráveis que acarreta danos indesejáveis, tanto ao paciente quanto para o profissional e o serviço de saúde. Por isso é de extrema relevância caracterizar a clientela assistida principalmente quando se trata de recém-nascidos de alto risco. Portanto, objetivou-se com este trabalho, de forma geral caracterizar os RNs internados em UTIs Neonatais, elencando os principais distúrbios responsáveis pelas internações dos RNs. Foi realizada uma busca ativa nas bases de dados eletrônicos MEDLINE/ PubMED e LILACS, e na SciELO.. A amostra foi constituída de 05 artigos científicos indexados nos bancos de dados de acesso livre: Sistema Online de Busca e Análise de Literatura Médica (MEDLINE) e Literatura Latino Americano e do Caribe em Ciências de Saúde (LILACS). A pesquisa foi desenvolvida nos meses de janeiro a março de 2016. Por essas considerações é necessário dentro dessas unidades conhecer o perfil sócio demográfico desses RNs assim como os principais distúrbios que os acometem pensando em estabelecer as melhores estratégias assistenciais buscando melhorar a qualidade dos cuidados prestados.Descritores: Recém Nascidos; Enfermagem Neonatal; Unidade de Terapia Intensiva Neonatal. Characterization Newborn Hospitalized in Intensive Care UnitsSummary: Providing care for the hospitalized human requires a lot of competence and security and neglecting this assistance allows for immeasurable errors that lead to undesirable damages to both the patient and the professional and the health service. Therefore it is extremely important to characterize the assisted clientele mainly when it comes to high risk newborns. Therefore, the objective of this study was to characterize the infants hospitalized in Neonatal ICUs, listing the main disorders responsible for NB hospitalizations. An active search was performed in the electronic databases MEDLINE / PubMED and LILACS, and in SciELO. The sample consisted of 05 scientific articles indexed in the databases of free access: Online System of Search and Analysis of Medical Literature (MEDLINE) and Latin American and Caribbean Literature in Health Sciences (LILACS). The research was developed from January to March 2016. For these considerations it is necessary within these units to know the socio-demographic profile of these newborns as well as the main disturbances that affect them, thinking of establishing the best care strategies to improve the quality of the care that is provide.

show abstract

“…A imunoglobulina endovenosa (IgEV) é uma opção que tem sido considerada como adjuvante no tratamento da sepse neonatal [6][7][8] . O conhecimento das características do desenvolvimento do sistema imunológico fetal e das deficiências dos mecanismos de defesa para proteção contra os patógenos neonatais forneceu argumentos teóricos para o uso de IgEV 9,10 .…”

Section: Conclusõesunclassified

Adjuvant use of intravenous immunoglobulin in the treatment of neonatal sepsis: a systematic review with a meta-analysis

Franco¹,

Torrico²,

Moreira³

et al. 2012

J Pediatr (Rio J)

View full text Add to dashboard Cite

Objective: To evaluate whether intravenous immunoglobulin reduces mortality and length of hospital stay in the treatment of neonatal sepsis. Sources:The MEDLINE database was searched. The keywords were combined using the following search strategy: [(sepsis OR shock, septic OR infection) AND immunoglobulins, intravenous] AND infant, newborn. Only randomized clinical trials (RCTs) showing good methodological quality and assessing the effect of adjuvant intravenous immunoglobulin in the treatment of neonatal sepsis were selected for inclusion and data analysis.Summary of the findings: Seven RCTs were selected. All of them evaluated the mortality rate, including 3,756 patients. The global effect of this outcome showed no statistically significant difference between the groups. Only five studies evaluated the mean length of hospital stay, including 3,672 patients. Although there is a statistically significant reduction of 1.24 days in the length of hospital stay with the use of intravenous immunoglobulin, such difference is clinically irrelevant and its high cost does not warrant its routine use in medical practice. The data reported in the present review contradict the review by Ohlsson et al., which was updated in 2010 and showed significant benefit with the use of intravenous immunoglobulin on both outcomes. Conclusions:We concluded that the use of adjuvant intravenous immunoglobulin shows no benefit regarding mortality, whereas the reduction in the length of hospital stay is irrelevant. J Pediatr (Rio J). 2012;88(5):377-83:Intravenous immunoglobulin, neonatal sepsis, septic shock, sepsis, infection, newborn infant. ResumoObjetivo: Avaliar se a imunoglobulina endovenosa reduz a mortalidade e o tempo de internação no tratamento da sepse neonatal. Fonte dos dados: 377378 Jornal de Pediatria -Vol. 88, N° 5, 2012 Uso da imunoglobulina endovenosa na sepse neonatal -Franco AC et al.

show abstract

Particularidades imunológicas do pré-termo extremo: um desafio para a prevenção da sepse hospitalar

Abstract: Como citar este artigo: Mussi-Pinhata MM, Rego MA. Particularidades imunológicas do pré-termo extremo: um desafio para a prevenção da sepse hospitalar.

Cited by 35 publications

References 14 publications

Accuracy of white blood cell count, C-reactive protein, interleukin-6 and tumor necrosis factor alpha for diagnosing late neonatal sepsis

Accuracy of white blood cell count, C-reactive protein, interleukin-6 and tumor necrosis factor alpha for diagnosing late neonatal sepsis

Caracterização dos Recém-Nascidos Internados em Unidades de Terapia Intensiva

Adjuvant use of intravenous immunoglobulin in the treatment of neonatal sepsis: a systematic review with a meta-analysis

Contact Info

Product

Resources

About