Avaliação dos fatores associados a infecções recorrentes e/ou graves em pacientes com síndrome de Down

Ribeiro, Luciana Machado; Jacob, Cristina Miuki Abe; Pastorino, Antônio Carlos; Kim, Chong A E; Fomin, Ângela B. F.; Castro, Ana Paula Beltran Moschione

doi:10.1590/s0021-75572003000200009

Cited by 13 publications

(12 citation statements)

References 19 publications

(18 reference statements)

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“…These pieces of evidence collectively raise confidence in the reliability of our results, showing that FXS and especially DS individuals may be particularly liable to develop urinary BKV infection, as compared to controls and ASD subjects. The present report is in line with previous data linking DS to increased incidence of bacterial and viral infections [5,32], as well as to immunodeficiency and decreased response to vaccination [33][34][35][36][37]. Several factors contribute since early childhood to diminish humoral and especially cell-mediated immunological surveillance in DS [4,38,39], increasing the incidence of primary and recurrent infections, while facilitating the reactivation of latent infections.…”

Section: Discussionsupporting

confidence: 91%

“…The incidence of DS is directly proportional to maternal age and on average affects 1:750 live births [2]. The disease is associated with mental retardation, congenital cardiac defects, autoimmune disorders (celiac disease, hypothyroidism, type I diabetes mellitus), immunodeficiency with increased incidence of bacterial and viral infections, and early onset Alzheimer's disease [3][4][5][6]. Interestingly, both genome-wide and chromosome 21-targetted expression studies have unveiled the consistent over-expression of only approximately 25% -30% of trisomic genes, in addition to 3% -6% of loci distributed on each of the remaining chromosomes [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Urinary polyomavirus infections in neurodevelopmental disorders

Gentile¹,

Altieri²,

Lintas³

et al. 2013

OJPsych

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We have recently reported enhanced frequencies of polyomavirus infection in post-mortem brain tissue of autistic patients compared to controls. To further explore potential contributions to neurodevelopmental disorders by polyomaviruses, we have employed specie-specific TaqMan assays to assess the prevalence and titres of BKV, JCV and SV40 inthe urines of 87 patients with autism spectrum disorder, 84 controls matched by sex and age with the autistic sample, 15 subjects with Down syndrome and 13 fragile X individuals. Prevalence rates of urinary BKV infection were significantly greater in Down syndrome and fragile X patients compared to autistic and control individuals (P < 0.01). In a large majority of patients who showed the presence of urinary genomes, viral titres resulted significantly higher among Down syndrome patients (P < 0.01) compared to controls, autism spectrum disorder and fragile X individuals, who did not significantly differ from each other. Our results are consistent with previous evidence supporting hampered immunological surveillance and/or immune deficits in fragile X and especially in Down syndrome patients.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Urinary polyomavirus infections in neurodevelopmental disorders

Gentile¹,

Altieri²,

Lintas³

et al. 2013

OJPsych

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“…Regarding to the investigation of humoral immunity, found values within the normal limits only in DS patients, as in our study [13]. There are few studies of complement system in DS individuals, in which are observed both normality and increase in C3 and C4 [25,26]. making them more susceptible to recurrent infections.…”

Section: Discussionsupporting

confidence: 66%

Immunological Profile of Patients Presenting Down Syndrome and Alopecia Areata

Ribeiro¹

2015

Adv Tech Biol Med

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Aim: This study was undertaken to contribute to knowledge of the immunological profile of Down syndrome and alopecia areata patients. Material and Methods: Observational, case series study, with comparison group. The following data were computed: gender, age, karyotype, previous disease and immunological profile: complete blood count, Blood Sedimentation Rate (BSR), cellular and humoral immunity and autoimmunity. Frequency, central trends and dispersion measurements for descriptive analysis. The nonparametric χ 2 test and Fisher Exact test for exploratory analyses; significance level for p value < 0.05. Results: Eighty-three Down Syndrome (DS) patients were evaluated: 21 with Alopecia Areata (AA) and 62 without it. The average age of patients with AA was 13.3 years (SD ± 5.0) and of DS without AA was 12.2 (SD ± 5.3); 94.7% presented free trisomy. The predominant previous illness was hypothyroidism, which occurred only in DS patients with AA (3/21). Hemogram was normal in 40.9% and the most frequent alteration was an increase of hematocrit (22.9%). The BSR was elevated in 71.1%. About cellular immunity, the principal abnormality was the decrease in CD4. Immunoglobulin electrophoresis was normal in 100.0%; DS patients showed normal levels of IgA in 100.0% of cases, of IgM in 98.8% and IgG, in 85.5%. Complement C4 and C3 were decreased in 67.4% and in 9.6% of the patients, respectively. The majority of studied antibodies were non reagent, but the presence of antiperoxidase antibody was significant in DS patients with AA. Conclusion: There was no significant difference between the groups, related to their immunological profile, except for the presence of antiperoxidase antibody that maybe associated with the presence of hypothyroidism in DS patients with AA. Perhaps some of the findings are justified by the small sample; the authors suggest further studies with a larger sample and with HLA testing in order to understand the mechanism of AA in DS.

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“…Dessa forma, a identificação de obesidade nesse grupo mostra-se de grande importância, uma vez que esta influencia no surgimento de riscos de morbimortalidade 10,11 . Na avaliação do estado nutricional de portadores de Síndrome de Down é recomendado que sejam utilizadas curvas de crescimento específicas para essa população, uma vez que possuem desenvolvimento inferior às pessoas em geral 2,12 .…”

Section: Introductionunclassified

Excesso De Pes E Gordura Corporal Em Portadores De Síndrome De Down De Uma Instituição No Município De Divinópolis – Mg

Souza

Rodrigues

Ferreira

2014

Rev. Bras. Ciên. Saúde

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Introdução: Os portadores de Síndrome de Down possuem alterações no desenvolvimento físico e mental e podem apresentar distúrbios da tireoide, alterações endócrinas e obesidade. Objetivo: Avaliar a prevalência de excesso de peso e gordura corporal, bem como caracterizar a ingestão alimentar de portadores de Síndrome de Down de uma instituição de Divinópolis -MG. Métodos: Índice de Massa Corporal (IMC), circunferência da cintura, percentual de gordura e quantificação da ingestão alimentar (registro alimentar) foram utilizados para classificação nutricional. Resultados: A amostra foi composta por 26 portadores, 57,7% dos avaliados apresentaram excesso de peso, 50% foram classificados como alto percentual de gordura e 100% dos indivíduos do gênero feminino, e apenas 33,3% do gênero masculino, estavam com circunferência da cintura elevada (p<0,05). Sobre a ingestão alimentar, 57,9% dos avaliados ingeriram valores acima das necessidades energéticas, já em crianças esse percentual foi de 100%. Alto percentual de inadequação de micronutrientes foi encontrado. Conclusão: O excesso de peso foi prevalente nessa população, principalmente em adultos. Além disso, mulheres apresentaram percentual maior de circunferência da cintura elevada e de gordura em relação aos homens. Introdução de hábitos alimentares saudáveis é uma intervenção importante nesses indivíduos.Palavras-chave: síndrome de down; obesidade; ingestão de alimentos; estado nutricional. ResuMOIntroduction: Down Syndrome have changes in physical and mental development and may have thyroid and endocrine disorders and obesity. Objective: To assess the prevalence of overweight and body fat, as well as characterize the dietary intake of individuals with Down Syndrome in an institution in Divinópolis -MG. Methods: Body mass index, waist circumference and body fat percentage and quantification of food intake (food record), were used for nutritional classification. Results: The sample consisted by 26 patients, 57.7% of the individuals were overweight, 50% were classified as high-fat percentage and, 100% of females and only 33,3% in males, have a high waist circumference (p<0.05). On food intake, 57.9% of energy intake was above energy needs, since children in this percentage was 100%. There was a high percentage of inadequacy of micronutrient intake. Conclusion: Overweight was prevalent in this population, especially in adults. In addition, women had a higher percentage of large waist circumference and fat than men. Introducing healthy eating habits is as important in these individuals. AbstRACt EXCESSO DE PESO E GORDURA CORPORAL EM PORTADORES DE SÍNDROME DE DOWN DE UMA INSTITUIÇÃO NO MUNICÍPIO DE DIVINÓPOLIS -MGOverweight and bOdy fat in patients with dOwn syndrOme in an institutiOn in divinópOlis -mg Artigos originAis RBCS Revista Brasileira de Ciências da Saúde, ano 11, nº 37, jul/set 2013

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Avaliação dos fatores associados a infecções recorrentes e/ou graves em pacientes com síndrome de Down

Abstract: Although the data found in this study are valid for this specific population, the authors point out the necessity of the immunodeficiency research in Down syndrome patients with maintenance of infection besides the appropriated control of associated diseases.

Cited by 13 publications

References 19 publications

Urinary polyomavirus infections in neurodevelopmental disorders

Urinary polyomavirus infections in neurodevelopmental disorders

Immunological Profile of Patients Presenting Down Syndrome and Alopecia Areata

Excesso De Pes E Gordura Corporal Em Portadores De Síndrome De Down De Uma Instituição No Município De Divinópolis – Mg

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