Urinary polyomavirus infections in neurodevelopmental disorders

Gentile, Ivan; Altieri, Laura; Lintas, Carla; Sacco, Roberto; Curatolo, Paolo; Benvenuto, Arianna; Muratori, Filippo; Santocchi, Elisa; Bravaccio, Carmela; Lenti, C; Faggioli, Raffaella; Rigardetto, Roberto; Gandione, Marina; Portella, Giuseppe; Zappulo, Emanuela; Borgia, Guglielmo; Persico, Antonio M.

doi:10.4236/ojpsych.2013.32a004

Cited by 3 publications

(2 citation statements)

References 63 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In some cases, ASD has been linked to infection (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39). A viral infection may per se damage the central nervous system or it might trigger an autoimmune reaction against some cerebral regions (11).…”

Section: (Asd) Are Neurodevelopmental Disorders Without a Definitive mentioning

confidence: 99%

Prevalence of Congenital Cytomegalovirus Infection Assessed Through Viral Genome Detection in Dried Blood Spots in Children with Autism Spectrum Disorders

Gentile

Zappulo

Riccio

et al. 2017

Self Cite

View full text Add to dashboard Cite

Section: (Asd) Are Neurodevelopmental Disorders Without a Definitive mentioning

confidence: 99%

Prevalence of Congenital Cytomegalovirus Infection Assessed Through Viral Genome Detection in Dried Blood Spots in Children with Autism Spectrum Disorders

Gentile

Zappulo

Riccio

et al. 2017

Self Cite

View full text Add to dashboard Cite

“…During the development process, infection is a common cause of illness. Although current studies focus on single factors, the growth process is often the combined action by the environment in a variety of factors [3]. Recently, double-hit models are used to study chronic/tonic pain [4] as well as stress dysregulation [5].…”

Section: Introductionmentioning

confidence: 99%

The Expression Change of GFAP and HMGB1 in Primary Cultured Astrocytes Exposed to Chlorpyrifos and Lipopolysaccharide

Wang¹,

Zhao²

2017

Proceedings From the ICERP 2016

View full text Add to dashboard Cite

Background and Objective: During the development of the nervous system, the impact of adverse environmental factors can cause serious consequences. Chemicals, toxic substances and infections are considered as common risk factors. In order to find the impact of environmental pollutants pesticides and infections on the nervous system, we attempt to investigate the effect of CPF (chlorpyrifos) and LPS (lipopolysaccharide) combined exposure on the release of GFAP/HMGB1 and activation in the primary cultured astrocyte of neonatal rat cerebral cortex. Methods: In this paper, trypsin digestion was used to isolate and purify astrocytes, and identify the cell based on immunofluorescence method; Astrocyte in experiment group was exposed to different concentrations of LPS and CPF. Astrocyte's activities were observed via CCK-8; Immunofluorescence and Western blot were used to measure the changes on the expression level of GFAP as well as HMGB1 in astrocyte. Results: Astrocyte's synaptic network was significantly increased at 24 h after being exposed to 25, 50 μMCPF combined with 1 μg/mL LPS; The expression level of glial fibrillary acidic protein (GFAP). High mobility group box 1(HMGB1) increased after astrocytes were exposed to 25, 50 μM CPF combined with 1 μg/mL LPS (p<0.05), The expression level of GFAP and HMGB1 decreased after being exposed to 100 μM CPF combined with 1 μg/mL LPS(p<0.05). 4) Conclusion: 1. CPF and LPS can not only cause astrocyte activation but also increase the expression of GFAP and HMGB1. 2. The effect of CPF combined with LPS is more obvious than CPF or LPS respectively on astrocytes, which indicates that they have a synergistic effect.

show abstract

No Evidence of Congenital Varicella Zoster Virus Infection Assessed Through Dried Blood Spot in Children With Autism Spectrum Disorders

et al. 2017

View full text Add to dashboard Cite

Aim: Several authors have hypothesized an association between congenital viral infections and the onset of autism spectrum disorders (ASD). We aimed to assess the prevalence of congenital varicella zoster virus (VZV) infection in patients with ASD. Patients & methods: Congenital infection by VZV was evaluated in a cohort of 38 children with ASD and in 44 healthy controls. PCR for VZV-DNA performed on dried blood spots collected at birth. Results & conclusion: No VZV infection was detected in both groups. With the limitation of the small sample size of this study, the results are not in favor of a role of VZV in the etiology of ASD.

show abstract

Urinary polyomavirus infections in neurodevelopmental disorders

Cited by 3 publications

References 63 publications

Prevalence of Congenital Cytomegalovirus Infection Assessed Through Viral Genome Detection in Dried Blood Spots in Children with Autism Spectrum Disorders

Prevalence of Congenital Cytomegalovirus Infection Assessed Through Viral Genome Detection in Dried Blood Spots in Children with Autism Spectrum Disorders

The Expression Change of GFAP and HMGB1 in Primary Cultured Astrocytes Exposed to Chlorpyrifos and Lipopolysaccharide

No Evidence of Congenital Varicella Zoster Virus Infection Assessed Through Dried Blood Spot in Children With Autism Spectrum Disorders

Contact Info

Product

Resources

About