Defeitos de fechamento do tubo neural e fatores associados em recém-nascidos vivos e natimortos

Aguiar, Marcos José Burle de; Campos, Ângela S.; Aguiar, Regina Amélia Lopes Pessoa de; Lana, Ana Maria Arruda; Magalhães, Renata L.; Babeto, Luciana T.

doi:10.1590/s0021-75572003000200007

Cited by 53 publications

(90 citation statements)

References 15 publications

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“…maior frequência em recém-nascidos do sexo feminino 11,12,13 . No entanto, neste estudo a frequência maior foi do sexo masculino, o que é corroborado por outros estudos 3,10 . Este estudo não mostrou relação entre o peso de nascimento e a espinha bífida, já que a maioria tinha peso maior que 2500g ao nascer.…”

Section: Resultsunclassified

“…A carência de ácido fólico é o fator de risco para os DFTN mais importante encontrado até hoje e a suplementação de ácido fólico periconcepcional pode reduzir tanto a ocorrên-cia como o risco de recorrência dessas malformações em torno de 70% 3,18 .…”

Section: Quanto à Distribuição Da Espinha Bífida Segundo O Sexo Váriunclassified

“…As pesquisas com população portadora de DFTN, entre eles a espinha bífida, têm mostrado resultados conflitantes em relação a variável paridade. Enquanto alguns estudos mostram que o risco para os DFTN aumenta com a multiparidade, três ou mais gestações 5,12 , outros estudos, inclusive com a população brasileira, descrevem uma menor prevalência de DFTN em multíparas 3,13 .…”

Section: Quanto à Distribuição Da Espinha Bífida Segundo O Sexo Váriunclassified

“…Essa malformação possui herança multifatorial, ou seja, interação entre vários genes e fatores ambientais 3,4,5 . Dentre os fatores ambientais estão as condições socioeconô-micas, deficiência de folato e alimentos contaminados com inseticidas.…”

Section: Introductionunclassified

“…dades crônicas graves, tais como: hidrocefalia, bexiga neurogênica, disfunção intestinal, problemas ortopédicos e paralisia de membros inferiores 3,5 . Além dessas incapacidades podem apresentar também transtornos emocionais sociais e psicossociais, e deficiência cognitiva.…”

Section: Introductionunclassified

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Perfil clínico-epidemiológico de crianças e adolescentes que vivem e convivem com espinha bífida

Gaíva

Corrêa

Santo

2011

J. Hum. Growth Dev.

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Section: Resultsunclassified

Section: Quanto à Distribuição Da Espinha Bífida Segundo O Sexo Váriunclassified

Section: Introductionunclassified

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Perfil clínico-epidemiológico de crianças e adolescentes que vivem e convivem com espinha bífida

Gaíva

Corrêa

Santo

2011

J. Hum. Growth Dev.

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Prevalence of Detection of Clostridioides difficile Among Asymptomatic Children

et al. 2021

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IMPORTANCE Detection of Clostridioides difficile has frequently been described in asymptomatic infants and children, but accurate estimates across the age spectrum are unavailable. OBJECTIVE To assess the prevalence of C difficile detection among asymptomatic children across the age spectrum. DATA SOURCES This systematic review and meta-analysis included a search of the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, CINAHL, Scopus, and Web of Science for articles published from January 1, 1990, to December 31, 2020. Search terms included Clostridium difficile, Peptoclostridium difficile, Clostridioides difficile, CDF OR CDI OR c diff OR c difficile, Clostridium infections OR cd positive diarrhea OR cd positive diarrhea OR Clostridium difficile OR Peptoclostridium difficile OR pseudomembranous colitis OR pseudomembranous enterocolitis, enterocolitis, and pseudomembranous. These were combined with the following terms: bacterial colonization and colonization OR colonized OR colonizing OR epidemiology OR prevalence OR seroprevalence. STUDY SELECTION Studies were screened independently by 2 authors. Studies were included if they reported testing for C difficile among asymptomatic children (ie, children without diarrhea) younger than 18 years.DATA EXTRACTION AND SYNTHESIS Data were extracted independently and in duplicate by 2 reviewers. Preferred Reporting Items for a Systematic Review and Meta-analysis (PRISMA) guidelines were used. Data were pooled using a random-effects model. MAIN OUTCOMES AND MEASURESThe primary outcome was prevalence of C difficile detection among asymptomatic children. Secondary outcomes included prevalence of toxigenic vs nontoxigenic strains of C difficile and prevalence of C difficile detection stratified by geographic region, income status, testing method, and year of testing. RESULTS A total of 95 studies with 19 186 participants were included. Rates of detection of toxigenic or nontoxigenic C difficile were greatest among infants aged 6 to 12 months (41%; 95% CI, 32%-50%) and decreased to 12% (95% CI, 7%-18%) among children aged 5 to 18 years. The prevalence of toxigenic C difficile colonization was lower, peaking at 14% (95% CI, 8%-21%) among infants aged 6 to 12 months and decreasing to 6% (95% CI, 2%-11%) among children older than 5 years. Although prevalence differed by geographic region (ie, North and South America vs Europe: β, −0.151, P = .001; North and South America vs Western Pacific: β, 0.136, P = .007), there was no difference by testing method (ie, culture vs polymerase chain reaction: β, 0.069, P = .052; culture vs enzyme immunoassay: β, −0.178, P = .051), income class (low-middle income vs high income: β, −0.144, P = .23; upper-middle vs high income: β, −0.020,

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Genetic causes of intellectual disability in a birth cohort: A population‐based study

Karam

Riegel

Segal

et al. 2015

American J of Med Genetics Pt A

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Intellectual disability affects approximately 1–3% of the population and can be caused by genetic and environmental factors. Although many studies have investigated the etiology of intellectual disability in different populations, few studies have been performed in middle‐income countries. The present study estimated the prevalence of genetic causes related to intellectual disability in a cohort of children from a city in south Brazil who were followed from birth. Children who showed poor performance in development and intelligence tests at the ages of 2 and 4 were included. Out of 4,231 liveborns enrolled in the cohort, 214 children fulfilled the inclusion criteria. A diagnosis was established in approximately 90% of the children evaluated. Genetic causes were determined in 31 of the children and 19 cases remained unexplained even after extensive investigation. The overall prevalence of intellectual disability in this cohort due to genetic causes was 0.82%. Because this study was nested in a cohort, there were a large number of variables related to early childhood and the likelihood of information bias was minimized by collecting information with a short recall time. This study was not influenced by selection bias, allowing identification of intellectual disability and estimation of the prevalence of genetic causes in this population, thereby increasing the possibility of providing appropriate management and/or genetic counseling. © 2015 The Authors. American Journal of Medical Genetics Part A Published by Wiley Periodicals, Inc.

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Defeitos de fechamento do tubo neural e fatores associados em recém-nascidos vivos e natimortos

Abstract: The neural tube defect prevalence found in this study was higher than the one described in international and Latin-American literature.

Cited by 53 publications

References 15 publications

Perfil clínico-epidemiológico de crianças e adolescentes que vivem e convivem com espinha bífida

Perfil clínico-epidemiológico de crianças e adolescentes que vivem e convivem com espinha bífida

Prevalence of Detection of Clostridioides difficile Among Asymptomatic Children

Genetic causes of intellectual disability in a birth cohort: A population‐based study

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