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doi:10.1590/s0004-282x2012000100023

Cited by 2 publications

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“…Neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorders (NMOSD) are a group of inflammatory disorders of the CNS characterized by immune-mediated demyelination and axonal damage, with primary target sites being the optic nerves and the spinal cord [1]. The usual presentation often involves sudden onset, severe episodes of optic neuritis and longitudinally extensive transverse myelitis [3]. The disease is most commonly associated with the presence of serum NMO-IgG antibodies that selectively bind aquaporin-4 (AQP4) and are highly disease specific [1].…”

Section: Discussionmentioning

confidence: 99%

Intractable Vomiting and Hiccups: An Atypical Presentation of Neuromyelitis Optica

Prabhu

Agrawal

2019

Cureus

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Neuromyelitis optica is an inflammatory disorder of the central nervous system. It involves the immune-mediated demyelination of predominantly the optic nerves and the spinal cord, which can lead to optic neuritis and transverse myelitis, respectively. Patients usually present with symptoms related to the eyes or the spinal cord, like loss of vision, pain in the eyes, visual field defects or numbness and weakness of limbs. Vomiting and hiccups are common cases encountered in medicine clinics and can sometimes be an atypical presentation of this disorder. Here we present a case of a 33-year-old female who initially presented to our tertiary care centre with repeated episodes of bilious vomiting and intractable hiccups for 10 days. After multiple investigations over a couple of days, the patient was found to be positive for anti-NMO antibodies and displayed neuro-radiological findings on MRI brain and spine, which finally led to the diagnosis of neuromyelitis optica spectrum disorder (NMOSD). Through this case we highlight the importance of suspecting NMO in a patient with complaints of intractable vomiting and hiccups, so that early intervention and treatment can prevent further disabling complications of the disease.

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Section: Discussionmentioning

confidence: 99%

Intractable Vomiting and Hiccups: An Atypical Presentation of Neuromyelitis Optica

Prabhu

Agrawal

2019

Cureus

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What’s new in neuromyelitis optica? A short review for the clinical neurologist

et al. 2017

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The evolution of neuromyelitis optica spectrum disorder (NMOSD) from a rare, incurable and misunderstood disease with almost universally poor outcomes to its present state in just over a decade is unprecedented in neurology and possibly in medicine. Our knowledge of NMOSD biology has led to the recognition of wider phenotypes, new disease mechanisms, and thus clinical trials of new and effective treatments. This article aims to update readers on the recent developments in NMOSD with particular emphasis on clinical advances, the 2015 diagnostic criteria, biomarkers, imaging, and therapeutic interventions.

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Cited by 2 publications

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Intractable Vomiting and Hiccups: An Atypical Presentation of Neuromyelitis Optica

Intractable Vomiting and Hiccups: An Atypical Presentation of Neuromyelitis Optica

What’s new in neuromyelitis optica? A short review for the clinical neurologist

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