Lees' syndrome: a case series

Becker, Nílson; Munhoz, Renato P.; Teive, Hélio A.G.

doi:10.1590/s0004-282x2011000600006

Cited by 7 publications

(5 citation statements)

References 32 publications

(45 reference statements)

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“…Impulsive compulsive behaviours (ICBs) are increasingly recognized as a devastating complication of Parkinson's disease (PD) treatment, and include pathological gambling, compulsive sexual disorder, excessive inappropriate shopping, binge eating, compulsive shopping, and the dopamine dysregulation syndrome (Lees syndrome) [1, 2]. ICBs have been reported to be no more frequent in untreated PD than in the general population, which would suggest that PD pathology alone is unlikely to increase the risk of addictive behaviours [3, 4].…”

Section: Introductionmentioning

confidence: 99%

Jumping to conclusions in untreated patients with Parkinson's disease

et al. 2016

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Background Jumping to conclusions due to impulsivity has been shown to be a sensitive marker for dopamine dysregulation and addictive behaviour patterns in treated patients with Parkinson's disease (PD). It is unknown whether drug naïve PD patients, who have never received dopaminergic therapy also have deficits in information sampling. Methods Twenty five de novo PD patients and twenty matched healthy controls were recruited and tested on the beads task, which is a validated information sampling task to assess reflection impulsivity and a temporal discounting questionnaire. Results Patients gathered significantly less information and made more irrational choices than matched controls. There was, however, no group difference on the temporal discounting questionnaire. Conclusions Poor information sampling and irrational decision making may be an inherent component of the neuropsychological deficit in Parkinson's disease. These findings suggest that underlying impulsivity detected by a metric task is common in de novo PD.

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Section: Introductionmentioning

confidence: 99%

Jumping to conclusions in untreated patients with Parkinson's disease

et al. 2016

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“…It is associated with severe LID and behavioral disturbances, including restlessness, aggression, dysphoria, anhedonia, and irritability during off periods, with compulsive demand for dopaminergic drugs. 83 The effects of STN or GPi DBS on DDS are still unclear and many groups have argued that STN DBS, in particular, may be beneficial by facilitating dose reduction of dopaminergic drugs. However, one recent study assessing the effect of STN and GPi DBS on DDS did not show any significant change; therefore, a neutral effect.…”

Section: Effects Of Dbs On Parkinson's Disease Symptomsmentioning

confidence: 99%

Fundamentals of deep brain stimulation for Parkinson's disease in clinical practice: part 1

Aquino,

Moscovich,

Marinho

et al. 2024

Arq Neuropsiquiatr

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Deep brain stimulation (DBS) is recognized as an established therapy for Parkinson's disease (PD) and other movement disorders in the light of the developments seen over the past three decades. Long-term efficacy is established for PD with documented improvement in the cardinal motor symptoms of PD and levodopa-induced complications, such as motor fluctuations and dyskinesias. Timing of patient selection is crucial to obtain optimal benefits from DBS therapy, before PD complications become irreversible. The objective of this first part review is to examine the fundamental concepts of DBS for PD in clinical practice, discussing the historical aspects, patient selection, potential effects of DBS on motor and non-motor symptoms, and the practical management of patients after surgery.

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“…Patients with punding have more psychiatric symptoms, greater impulsivity, and are more likely to have other impulsive compulsive behaviors (ICBs) 4 . Punding has also been linked with the dopamine dysregulation syndrome 3 (Lees syndrome) 5 and l ‐dopa peak dose dyskinesias 6 . Although excessive hobbyism is commonly associated with punding and placed together with punding in the Questionnaire for Impulsive‐Compulsive Disorders in Parkinson's Disease‐Rating Scale (QUIP‐RS), the relationship between these two behavioral abnormalities has not been fully elucidated yet.…”

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confidence: 99%

Neuropsychiatric Features of Punding and Hobbyism in Parkinson's Disease

Barbosa

O’Sullivan

Joyce

et al. 2021

Movement Disord Clin Pract

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Background Little is known about the cognitive and neuropsychiatric profile associated with punding and hobbyism in Parkinson's disease (PD). Objective To compare the clinical and neuropsychological features of PD patients with punding and hobbyism to PD controls. Methods The Questionnaire for Impulsive‐Compulsive Disorders in Parkinson's Disease‐Rating Scale (QUIP‐RS) was used as a screening tool, and a structured interview was used to diagnose punding/hobbyism. Clinical and neuropsychological assessment was conducted with validated questionnaires/scales. Results Twenty‐one patients with PD and punding (PD + pu) were compared to 26 with hobbyism (PD + h) and 25 PD controls. PD + pu patients showed higher levels of anxiety, non‐motor symptoms and motor symptoms, and lower Frontal Assessment Battery scores. The PD + h group exhibited similar levels of anxiety and motor fluctuations to the PD + pu group. Conclusion PD + pu showed increased anxiety and frontal lobe dysfunction, similar to PD + h. Hobbyism could be a prodromal phase with increased risk of leading to punding.

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Lees' syndrome: a case series

Abstract: We report a case series of dopamine dysregulation syndrome, previously known as hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine replacement therapies, now designated as Lees' syndrome.

Cited by 7 publications

References 32 publications

Jumping to conclusions in untreated patients with Parkinson's disease

Jumping to conclusions in untreated patients with Parkinson's disease

Fundamentals of deep brain stimulation for Parkinson's disease in clinical practice: part 1

Neuropsychiatric Features of Punding and Hobbyism in Parkinson's Disease

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