Fundamentals of deep brain stimulation for Parkinson's disease in clinical practice: part 1

Abstract

Deep brain stimulation (DBS) is recognized as an established therapy for Parkinson's disease (PD) and other movement disorders in the light of the developments seen over the past three decades. Long-term efficacy is established for PD with documented improvement in the cardinal motor symptoms of PD and levodopa-induced complications, such as motor fluctuations and dyskinesias. Timing of patient selection is crucial to obtain optimal benefits from DBS therapy, before PD complications become irreversible. The objective of this first part review is to examine the fundamental concepts of DBS for PD in clinical practice, discussing the historical aspects, patient selection, potential effects of DBS on motor and non-motor symptoms, and the practical management of patients after surgery.

Tailoring and personalizing deep brain stimulation for Parkinson's disease

“…This gap is in great part responsible for the disproportion between the number of PD patients to which surgery should be offered and the actual number of patients in which the surgery is actually and correctly performed. 2 In this issue of the journal, an article in two parts by Aquino and Moscovich et al 3,4 explored the state-of-the-art and new and future technologies in neuromodulation for PD. The authors reviewed the DBS indication criteria, expected outcomes, and possible targets according to patients' profiles, programming, and medication management.…”

“…In this issue of the journal, an article in two parts by Aquino and Moscovich et al 3 4 explored the state-of-the-art and new and future technologies in neuromodulation for PD. The authors reviewed the DBS indication criteria, expected outcomes, and possible targets according to patients' profiles, programming, and medication management.…”