Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats

Deiró, Teresa Cristina Bomfim de Jesus; Carvalho, J F de; Nascimento, Elizabeth do; Medeiros, J.M. Barreto; Cajuhi, Fabiana; Ferraz-Pereira, Kelli Nogueira; Manhães-de-Castro, Raul

doi:10.1590/s0004-282x2008000500025

Cited by 16 publications

(16 citation statements)

References 43 publications

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“…Animal models converge with evidence from human studies as early exposure to SSRIs results in delayed motor abilities in pre-weaning offspring and juvenile offspring [131][132][133].…”

Section: Motor Developmentmentioning

confidence: 87%

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Perinatal selective serotonin reuptake inhibitor (SSRI) effects on body weight at birth and beyond: A review of animal and human studies

Hutchison

Mâsse

Pawluski

et al. 2018

Reproductive Toxicology

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. Perinatal selective serotonin reuptake inhibitor (SSRI) effects on body weight at birth and beyond A review of animal and human studies. Reproductive Toxicology, Elsevier, 2018, 77, pp.109-121. 10 Highlights  Our paper reviews our current understanding of the impact of prenatal SSRI exposure on weight and growth using both human and animal findings.  Our review extends the previously published review paper by Grzeskowiak and colleagues in Repro Tox in 2012 by including findings beyond infancy, the impact of maternal mood -pre and post natal, and given that the majority our 5HT is in the gastrointestinal (GI) system we speculate that altering 5HT signaling, via SSRI exposure might have an impact on GI function and later weight gain.  With recent advances in our understanding of the gut-brain axis and the role of 5HT, we raise critical questions about how weight and growth outcomes might be related to SSRI induced changes in the GI microbiome.  Our paper provides an updated review of the literature (e.g., Leuner et al 2014;Nezvalová-Henriksen et al., 2016), with a particular focus on weight related outcomes beyond birth, developmental aspects of SSRI exposure that might also impact weight and growth, as well as provides detailed suggestions for future research. AbstractThe long-term impact of selective serotonin reuptake inhibitor (SSRI) antidepressant treatment during pregnancy and postpartum on offspring outcomes is still not clear. Specifically, perinatal SSRI exposure may have long-term consequences for body weight and related health outcomes in the newborn period and beyond. This review focuses on the impact of perinatal SSRI exposure on weight using human and animal findings. The impact of maternal mood is also explored. We propose potential mechanisms for weight changes, including how early alterations in serotonin signaling may have implications for weight via changes in metabolism and motor development.As the majority of serotonin is in the gastrointestinal (GI) system we also speculate that perinatal SSRI exposure might alter the brain-gut relationship, via the microbiome, leading to changes in feeding behavior and weight.

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“…Animal models converge with evidence from human studies as early exposure to SSRIs results in delayed motor abilities in pre-weaning offspring and juvenile offspring [131][132][133].…”

Section: Motor Developmentmentioning

confidence: 87%

“…This early postnatal exposure to SSRIs reduced weight at the pre-weaning and juvenile stage [90][91][92] and at adulthood in offspring [93]. Another study with postnatal SSRIs reduced weight at the pre-…”

Section: Animal Studiesmentioning

confidence: 99%

Perinatal selective serotonin reuptake inhibitor (SSRI) effects on body weight at birth and beyond: A review of animal and human studies

Hutchison

Mâsse

Pawluski

et al. 2018

Reproductive Toxicology

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“…Negative effects of neonatal administration of SSRI drugs on the change in body weight in the animals were registered in several studies. Thus, administration of citalopram [ 20 ], sertraline [ 19 , 22 ], and fluoxetine [ 18 ] during the early development period in rats causes growth deceleration. The serotoninergic system is known to play an important role in the regulation of appetite and food consumption.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, clinical studies of the effects of prenatal SSRI exposure are mostly focused on neonatal abnormalities, with data on the delayed effects of the exposure being limited. On the contrary, animal experiments are mostly aimed at estimating the long-term effects of perinatal SSRI administration [ 15 ]; studies of the neonatal effects are scarce [ 4 , 19 , 20 ]. However, studies of the acute effects of neonatal SSRI administration in animals are required to prove the adequacy of the experimental models in use.…”

Section: Introductionmentioning

confidence: 99%

Effects of Neonatal Fluvoxamine Administration on the Physical Development and Activity of the Serotoninergic System in White Rats

Glazova¹,

Merchieva²,

Володина³

et al. 2014

Acta Naturae

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Selective serotonin reuptake inhibitors (SSRIs), including fluvoxamine, are widely used to treat depressive disorders in pregnant women. These antidepressants effectively penetrate through the placental barrier, affecting the fetus during the critical phase of neurodevelopment. Some clinical studies have linked prenatal exposure to SSRIs with increased neonatal mortality, premature birth, decreased fetal growth and delay in psychomotor development. However, the effects of prenatal exposure to SSRIs remain unknown. The administration of SSRIs in rodents during the first postnatal weeks is considered as an model for studying the effects of prenatal SSRIs exposure in human. The aim of this work was to study the acute effects of chronic fluvoxamine (FA) administration in white rat pups. The study was carried out in male and female rat pups treated with FA (10 mg/kg/day, intraperitoneally) from postnatal days 1 to 14. The lethality level, body weight, age of eye opening, and motor reflex maturation were recorded. The contents of biogenic amines and their metabolites in different brain structures were also determined. It was shown that neonatal FA administration led to increased lethality level, reduced body weight, and delayed maturation of motor reflexes. Furthermore, increased noradrenalin level in hypothalamus, serotonin level in hippocampus and serotonin metabolite 5-HIAA level in frontal cortex, hypothalamus, hippocampus, and striatum were observed in drug-treated animals compared to the control group. We can conclude that the altered activity of the serotoninergic system induced by fluvoxamine administration at early developmental stages leads to a delay in physical and motor development.

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“…Many experimental and clinical outcomes have shown that injuries during the critical period can change the sequence of these events, causing various and persistent effects on the NS ontogenesis. Among factors that cause injuries, the use of drugs (Deiró et al, 2008), malnutrition (Anselmo et al, 2006) and changes in quantity and quality of dietary lipids stand out (Soares et al, 2009;Santillán et al, 2010;Soares et al, 2014). Linolenic (n-3) and linoleic acids (n-6), essential fatty acids and precursors of long-chain polyunsaturated fatty acids (LCPUFAs) are among dietary lipids (Blanchard et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Buriti oil (Mauritia flexuosa L.) negatively impacts somatic growth and reflex maturation and increases retinol deposition in young rats

Medeiros

Aquino

Soares

et al. 2015

Intl J of Devlp Neuroscience

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Buriti oil contains nutrients such as essential fatty acids and vitamins, which are directly involved with neonates' development. However, the refining process of this oil can change its nutrient profile. This study investigated the effects of maternal consumption of Buriti oil (crude or refined), on reflex and somatic development and retinol levels in neonatal rats. Thirty-six Wistar male neonate rats born from mothers who consumed diet with 7% lipids during gestation and lactation were used. Rats were randomized into three groups: rats receiving diet added of soybean oil (control-CG), crude Buriti oil (CB) and refined Buriti oil (RB). Offspring weight, tail length, reflex ontogeny and somatic maturation were assessed during lactation. At the end of the experiment, serum and liver retinol concentrations were measured. Animals from CB and RB groups showed delayed onset of palm grasp, righting reflex and cliff avoidance reflexes compared to the control group (CG). However, animals from RB group showed anticipation of auditory startle compared to those from BC group. Regarding somatic maturation indicators, animals from RB group showed delayed eye opening and eruption of superior and inferior incisors in relation to control and anticipation in the auditory conduit opening in relation to CB group. Rats from CB and RB groups showed higher serum and liver vitamin A contents. Buriti oil delays physical parameters and reflex maturation and increases serum and liver retinol deposition among neonatal rats.

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Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats

Cited by 16 publications

References 43 publications

Perinatal selective serotonin reuptake inhibitor (SSRI) effects on body weight at birth and beyond: A review of animal and human studies

Perinatal selective serotonin reuptake inhibitor (SSRI) effects on body weight at birth and beyond: A review of animal and human studies

Effects of Neonatal Fluvoxamine Administration on the Physical Development and Activity of the Serotoninergic System in White Rats

Buriti oil (Mauritia flexuosa L.) negatively impacts somatic growth and reflex maturation and increases retinol deposition in young rats

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