Teratoma sacrococcígeo: relato de três casos

Falavigna, Asdrúbal; Gandara, Carlos; Ferraz, Fernando Antônio Patriani; Saciloto, Bruno

doi:10.1590/s0004-282x2004000200026

Cited by 4 publications

(4 citation statements)

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“…These two latter associations are extremely rare [14]. In reality teratomas are able to develop anywhere in the body, but ovaries and scrotal regions are the common locations [18,19].…”

Section: Discussion Epidemiologymentioning

confidence: 99%

See 1 more Smart Citation

Mature Cystic Ovarian Teratoma: A Study of 43 Congolese Cases

Poaty¹,

Mboungou²,

Mavoungou³

et al. 2018

Hereditary Genet Curr Res

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Background: The mature cystic ovarian teratoma (MCOT) is a common benign ovarian neoplasm in the world, most prevalent among women of childbearing age. It is a disease related to parental imprinting in which genome is exclusively maternal. The purpose of the study was to review the tumour features in Congolese patients in order to clarify its prevalence, and its histological forms and to report the eventual associated chromosomal anomalies described in literature. Methods: It was a retrospective study of MCOT seen in University Teaching Hospital of Brazzaville for a period of seven years, and five DNAs previously extracted from five MCOT. Two antibodies: DLK1 and TIMP2 were also studied by immunohistochemistry (IHC). The confirmed positive diagnosis was performed by Hematoxylin-Eosin method. The eventual presence of chromosomal anomalies was investigated by metaphasic Comparative Genomic Hybridization (mCGH) method. IHC analysis had permit to verify expression of paternal imprinted gene DLK1 expression compared to maternal imprinted gene TIMP2. Results: During the study period, a total of 215 cases of ovarian neoplasms have been seen, from which 20% (43/215 cases) with confidence interval (CI) 95% = [14.7%-25.3%] were diagnosed MCOT. They represent 38.7% (43/111 cases) (IC 95% = [29.9%-48.1%]) of all benign ovarian tumors and they account for 0.4% (43/10170) of all tumors diagnosed during the study period. The average age of patients having MCOT was 30.7 years with extreme ranging from 2 to 70 years. Cutaneous tissue was the most prevalent histological form. About IHC analysis, no staining was observed with mono-allelic paternal gene DLK1 contrasting with high TIMP2 staining of nuclear stem cells in the basal layer of the epidermis. Concerning mCGH, no profile revealed chromosomal rearrangements. Conclusion: The benign ovarian teratoma remains a common ovarian neoplasm in young Congolese women in reproductive age. The predominant skin tissue form signed the current called ovarian dermoid cyst. The CGH analysis in our study revealed that pathology is not associated with chromosomal anomalies, but some associations are described in literature.

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“…These two latter associations are extremely rare [14]. In reality teratomas are able to develop anywhere in the body, but ovaries and scrotal regions are the common locations [18,19].…”

Section: Discussion Epidemiologymentioning

confidence: 99%

“…Usually, teratomas are found in sacrococcygeal area in 57% of cases among children [4,19], that account for 1 per 21,700-35,000 live births [22,23]. That form is rare among adults (incidence of 1:87,000) [9].…”

Section: Discussion Epidemiologymentioning

confidence: 99%

Mature Cystic Ovarian Teratoma: A Study of 43 Congolese Cases

Poaty¹,

Mboungou²,

Mavoungou³

et al. 2018

Hereditary Genet Curr Res

View full text Add to dashboard Cite

show abstract

“…Sacrococcygeal teratomas are neoplasias, which are most frequently found in infants, with the sacrococcígea area being the most frequently found extragonadal location [1,6,7,9]. They are derived tumors of cells embryonic pluripotencies and they can be divided into three classes: mature, immature, or malignant.…”

Section: Introductionmentioning

confidence: 99%

“…The cause of their occurrence remains unknown; however, there are existing theories that try to explain the emergence of those tumors in the sacrococcígea area [7,8,11]. The incidence is one case in every 30,000-170,000 being born alive and are more frequent in females to a proportion of 2-4:1 [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%