Multifocal osteoclastoma of the skull: case report

Quadros, Ricardo Souza; Sousa, Atos Alves de; Carvalho, Gervásio Teles Cardoso de; Filho, Marcos Antônio Dellaretti

doi:10.1590/s0004-282x2004000100031

Cited by 4 publications

(5 citation statements)

References 13 publications

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“…25,38 A growing number of authors believe that GCTs are radiosensitive, and radiotherapy played an essential role in recurrence control. 3,6,8,9,17,27,29,33,35 Malone et al 25 reported that local control was achieved in 19 of 21 patients with radiotherapy and recommended the modality as an effective option if surgery was impossible or would result in significant morbidity. Therefore, postoperative radiation therapy was recommended to patients with at least one of the following entities: 1) malignant pathology with a Ki-67 index ≥ 10% regardless of extent of resection; 2) residual tumors regardless of Ki-67 index; and 3) recurrent GCT.…”

Section: Proposed Treatment Algorithmmentioning

confidence: 99%

Surgical management and long-term outcomes of intracranial giant cell tumors: a single-institution experience with a systematic review

Weng

Wang

et al. 2019

Journal of Neurosurgery

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OBJECTIVEIntracranial giant cell tumors (GCTs) are extremely rare neoplasms with dismal survival and recurrence rates. The authors aimed to confirm independent adverse factors for progression-free survival (PFS) and to propose an optimal treatment algorithm.METHODSThe authors reviewed the clinical data of 43 cases of intracranial GCTs in their series. They also reviewed 90 cases of previously reported GCTs in the English language between 1982 and 2017 using Ovid MEDLINE, Embase, PubMed, and Cochrane databases with keywords of “giant cell tumor” or “osteoclastoma” and “skull,” “skull base,” “temporal,” “frontal,” “sphenoid,” or “occipital.” These prior publication data were processed and used according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Aforementioned risk factors for the authors’ series and the pooled cases were evaluated in patients not lost to follow-up (m = 38 and n = 128, respectively).RESULTSThe authors’ cohort included 28 males and 15 females with a mean age of 30.5 years. Gross-total resection (GTR) was achieved in 15 (34.9%) patients. Fifteen patients (39.5%) who did not undergo GTR received postoperative radiotherapy with a mean total dose of 54.7 ± 4.1 Gy. After a mean follow-up of 71.3 months, 12 (31.6%) patients experienced recurrence, and 4 (10.5%) died of disease. The actuarial 5-year PFS and overall survival (OS) were 68.6% and 90.0% in the authors’ cohort, respectively. A multivariate Cox regression analysis verified that partial resection (HR 7.909, 95% CI 2.296–27.247, p = 0.001), no radiotherapy (HR 0.114, 95% CI 0.023–0.568, p = 0.008), and Ki-67 ≥ 10% (HR 7.816, 95% CI 1.584–38.575, p = 0.012) were independent adverse factors for PFS. Among the 90 cases in the literature, GTR was achieved in 49 (54.4%) cases. Radiotherapy was administered to 33 (36.7%) patients with a mean total dose of 47.1 ± 5.6 Gy. After a mean follow-up of 31.5 months, recurrence and death occurred in 17 (18.9%) and 5 (5.6%) cases, respectively. Among the pooled cases, the 5-year PFS and OS were 69.6% and 89.2%, respectively. A multivariate model demonstrated that partial resection (HR 4.792, 95% CI 2.909–7.893, p < 0.001) and no radiotherapy (HR 0.165, 95% CI 0.065–0.423, p < 0.001) were independent adverse factors for poor PFS.CONCLUSIONSGTR and radiotherapy were independent favorable factors for PFS of intracranial GCTs. Based on these findings, GTR alone or GTR plus radiotherapy was advocated as an optimal treatment; otherwise, partial resection plus radiotherapy with a dose ≥ 45 Gy, if tolerable, was a secondary alternative. Lack of randomized data of the study was stressed, and future studies with larger cohorts are necessary to verify these findings.Systematic review no.: CRD42018090878 (crd.york.ac.uk/PROSPERO/)

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Section: Proposed Treatment Algorithmmentioning

confidence: 99%

Surgical management and long-term outcomes of intracranial giant cell tumors: a single-institution experience with a systematic review

Weng

Wang

et al. 2019

Journal of Neurosurgery

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“…Although rare, cranial GCTs occur most frequently in the endochondral bone of the middle fossa floor [14], with a specific tendency to occur in the sphenoid and temporal bones [15]. GCTs of the skull typically present in the third and fourth decades of life [16,17], with a slightly higher predominance in women and a high rate of recurrence (40-60%) [18]. These tumors are exceptionally rare in individuals younger than 20 years of age [19].…”

Section: Discussionmentioning

confidence: 99%

Multicentric giant cell tumor in adolescents

Jung

Park

Lee

et al. 2013

Journal of Pediatric Orthopaedics B

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“…Two other series found none involving the skull among 189 39) and 327 cases. 5) Giant cell tumors of the skull typically present in the third and fourth decades of life 9,13,14,32) with equal sex distribution and a high rate of recurrence (40-60%). 22,36) This tumor is very rare in persons younger than 15 years or over 40 years of age.…”

Section: Discussionmentioning

confidence: 99%

Giant Cell Tumor of the Frontal Bone in a Girl -Case Report-

Kamoshima

Sawamura²,

Imai

et al. 2011

Neurol. Med. Chir.(Tokyo)

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A 2-year-old female presented with a rare case of recurrent giant cell tumor affecting the frontal bone. She had already undergone partial removal twice at the ages of 14 and 18 months. The tumor was located in the frontal bone, expanding to the ethmoid and orbital bones, and invading the frontal base dura mater. The tumor was totally removed including the surrounding bone and frontal base dura mater. No local recurrence and metastasis were observed at 18 months after the last operation. Most giant cell tumors occur in the epiphyses of long bones and are rare in the cranio-facial bone. These tumors usually affect young adults and few pediatric cases are reported.

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Multifocal osteoclastoma of the skull: case report

Cited by 4 publications

References 13 publications

Surgical management and long-term outcomes of intracranial giant cell tumors: a single-institution experience with a systematic review

Surgical management and long-term outcomes of intracranial giant cell tumors: a single-institution experience with a systematic review

Multicentric giant cell tumor in adolescents

Giant Cell Tumor of the Frontal Bone in a Girl -Case Report-

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