Fibrinogênio como fator de risco independente de doença vascular cerebral

Abstract

RESUMO -No protocolo de avaliação clínico-laboratorial de pacientes com acidente vascular cerebral (AVC) aterotrombótico dosamos e analisamos níveis de fibrinogênio plasmático (técnica de Clauss automatizada), para determinar seu possível papel como fator de risco trombogênico em 29 pacientes (20 homens e 9 mulheres) com idades entre 25 a 79 anos (mediana=55); todos tinham tido AVC aterotrombótico. Eles foram classificados em 2 grupos segundo alterações de fluxo nas carótidas: g1 -sem alteração de fluxo (n=19) e g2-com alteração de fluxo (n=10). Resultados-A média das dosagens de fibrinogênio no gl foi de 269 e no g2 de 353 mg/dl. Quarenta e sete por cento dos pacientes do gl e 80% do g2, apresentaram medidas >300 mg/dl. As diferenças obtidas entre os grupos neste estudo foram significantes. Conclusão-Considerando o nível de risco epidemiológico de 300 mg/dl, nossos resultados sugerem que o fibrinogênio é um fator de risco independente para AVC aterotrombótico, especialmente naqueles com alteração de fluxo carotídeo.PALAVRAS CHAVE: doença cerebrovascular, fibrinogênio, fator de risco, ultra-sonografia carotídea. Fibrinogen as independent risk factor for ischemic strokeABSTRACT -We have studied fibrinogen levels (Clauss technique) in atherothrombotic ischemic stroke patients, in order to determine its role as a thombogenic risk factor. Twenty nine patients (20 men and 9 women) between 25 and 79 years old were studied; they all have had a atherothrombotic stroke. They were classified into two groups according to the result of their carotid doppler ultrasonography: g1 -without carotid flow reduction (n=l 9) and g2 -with carotid flow reduction (n=10). The fibrinogen mean value was 269mg/dl in gl and 353 mg/dl in g2. There were 47% of patients in gl and 80% of patients in g2 who presented levels >300 mg/dl. The proportions of the groups were significantly different (p<0,05). Considering the epidemiological value of 300 mg/dl, we conclude that the fibrinogen can be an independent risk factor for ischemic atherothrombotic stroke, specially in those whose carotid flow is reduced.KEY WORDS: stroke, cerebrovascular disease, fibrinogen, risk factor, carotid ultrasonography.São vários os fatores de risco bem estabelecidos para doenças aterotrombóticas (coronariana e cerebrovascular, principalmente), como hipertensão arterial, hipercolesterolemia e tabagismo, por exemplo. Alguns outros fatores vêm sendo estudados e ainda não há consenso quanto à preditividade de alguns destes para tais eventos vasculares, dentre os quais o fibrinogênio tem se destacado. Há fatores que podem prognosticar maior risco, sendo considerados independentes; estes fatores de risco independentes interferem pela sua magnitude, isto é, quanto maior o seu valor, maior a probabilidade futura de doença.

Diagnostic implication of fibrin degradation products and D-dimer in aortic dissection

“…Fukujima et al . found that FDP participate the development and progression of atherosclerosis and thrombus30. Corban MT et al .…”

The NF-κB pathway: regulation of the instability of atherosclerotic plaques activated by Fg, Fb, and FDPs

“…Epidemiological studies have demonstrated that hyperfibrinogenemia is an independent risk factor for stroke, as well as that fibrinogen (Fg), fibrin (Fb), and fibrinogen degradation products (FDPs) are involved in the formation and development of atherosclerosis (AS) [1, 2]. Fg is a 340 kD glycoprotein which is constitutively expressed exclusively in hepatocytes [3].…”

Control of diabetes and fibrinogen levels as well as improvement in health care might delay low cognitive performance in societies aging progressively

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