Effects of misoprostrol on pentylenetetrazol-induced seizures in mice

Abstract

The effects of prostaglandin E-analogue misoprostol on the susceptibility to pentilenetetrazol (PTZ)-induced seizures were examined in mice. Misoprostol (200-800 micrograms/kg), given subcutaneously 45 min before the subconvulsive dose of PTZ (30 mg/kg, i.p) provoked dose-dependent clonic-tonic seizures (30 to 100%) and mortality in mice. At 300 g/kg, s.c., misoprostol pretreatment significantly (p < 0.05) lowered the onset latency to first convulsion as well as the latency to mortality induced by a convulsive dose of PTZ (60 mg/kg, i.p.). At this dose misoprostol was found to lower the CD50 and Ld50 values for PTZ by 21% and 36% respectively. The results suggest that prostaglandins are likely to lower the threshold for convulsions.

Sublingual Misoprostol-Induced Rhabdomyolysis and Convulsions in Postpartum Hemorrhage: A Case Report and Literature Review

“…According to previous reports, women who received misoprostol postpartum are at risk for shivering and fever [6]. The temperature elevations associated with misoprostol are due to hypothalamus adjustment [12]. E-series prostaglandins (PGEs) play an important role in the endogenous fever mechanism, especially prostaglandin E2 (PGE2) which is known as the mediator of fever induction, through interaction with the EP3 receptor, which is one of the subtypes of PGE receptors [13,14].…”

Misoprostol-induced seizures following self-abortion: a rare, but repeated occurrence

“…Few studies examine prostaglandin E analogues' seizure pathophysiology, but one study on mice reveals Misoprostol lowers seizure threshold. 4 It is crucial not to overlook other potential causes of recurrent seizures and status epilepticus. Epilepsy can be ruled out, given that this is a provoked, first-episode seizure with no previous history.…”