Endometriosis is defined as the presence of endometrial-like glands and stroma outside the uterine endometrial lining. Endometrial tissue has also been identified in numerous surgical or procedure scars, including cesarean section and laparoscopic trocar tract. A prospective study was conducted at Maternidade-Escola Assis Chateaubriand, Faculty of Medicine, Federal University of Ceara, Brazil in seven patients with abdominal wall mass pathologically proven as scar endometriosis from January 2004 to December 2008. All cases were submitted to fine-needle aspiration cytology (FNAC). Age ranged from 21 to 42 years old (mean: 30) with parity ranging from 0 to 3 (mean: 1.4). The preceding history of pelvic procedures was miomectomy (1 of 7), cesarean section (3 of 7), and diagnostic laparoscopy (3 of 7). The complaints occurred about 18 months after the surgical proceeding. The FNAC findings were endometrial-like epithelial cells (6 of 7) and stromal cells (6 of 7); decidualization occurred in 2 of 7 cases. Hemosiderin-laden macrophages were present in all cases. FNAC is a fast and accurate method to make the diagnosis before the surgery, avoiding errors in the approach of the abdominal wall endometriosis' scars.
PurposeTo assess the impact of sperm retrieval on the gonadal function of rats with impaired spermatogenesis by comparing testicular sperm extraction (TESE) to aspiration (TESA). The efficacy of these procedures to sperm obtainment was also compared.Materials and MethodsA pilot study showed impaired spermatogenesis, but normal testosterone (T) production after a bilateral orchidopexy applied to 26 rats, which were randomly assigned into four groups: TESE (n=7), TESA (n=7), SHAM (n=6) and Control (n=6). The T levels were measured through comparative analysis after the orchidopexy.ResultsThere was no statistical difference in the animal's baseline T levels after orchidopexy in comparison to the controls: the TESE and TESA groups, 6.66±4.67ng/mL; the SHAM group (orchidopexy only), 4.99±1.96ng/mL; and the Control, 4.75±1.45ng/mL, p=0.27. Accordingly, no difference was found in the postoperative T levels: TESE, 5.35±4.65ng/mL; TESA, 3.96±0.80ng/mL; SHAM, 3.70±1.27ng/mL; p=0.4. The number of sperm cells found through TESE (41.0±7.0) was significantly larger than that found through TESA (21.3±8.1, p=0.001). Moreover, higher tissue weight was found through TESE (0.09±0.02g versus 0.04±0.04g, p=0.04).ConclusionsThe testicular sperm capture performed in rats through extraction or aspiration, after orchidopexy, did not significantly decrease the T levels. The amount of sperm found through testicular sperm extraction was higher than that through testicular sperm aspiration.
We hypothesize that hyperlipidemia and IR may be involved in the pathophysiologic features of the elevated diastolic blood pressure in PCOS patients.
Os idosos pertencem a uma parcela da população que necessita de serviço de atenção farmacêutica com enfoque na promoção do uso racional de medicamentos, reduzindose, assim, os Problemas Relacionados a Medicamentos (PRM). Tratou-se de um estudo longitudinal, quantitativo, realizado com 27 idosos de comunidade de periferia de Fortaleza (Ceará), no período de agosto 2003 a junho 2004. O instrumento de coleta de dados consistiu de um questionário com perguntas abertas e fechadas, sendo permitida a intervenção do entrevistador, quando necessário. O método utilizado foi adaptado da primeira etapa do Método Dáder de Seguimento Farmacoterapêutico (STF) e baseou-se na obtenção da história farmacoterapêutica do paciente, para posterior avaliação do estado de situação, e na identificação e resolução dos possíveis PRM. Os resultados apontaram o uso excessivo de medicamentos. Em 19 idosos (70,3%) detectou-se a utilização de mais de um medicamento rotineiramente. A hipertensão arterial foi a doença crônica de maior freqüência relatada, atingindo 14 (51,8%) dos investigados; três faziam uso de fármacos de alto risco para as pessoas idosas. A partir deste trabalho constatou-se a necessidade de programas de atenção farmacêutica aos idosos objetivando uma posterior construção do estado de situação e intervenção quando necessário.Descritores: serviços de saúde para idosos, idosos; serviços de assistência farmacêutica; fármaco-epidemiologia.
The effects of prostaglandin E-analogue misoprostol on the susceptibility to pentilenetetrazol (PTZ)-induced seizures were examined in mice. Misoprostol (200-800 micrograms/kg), given subcutaneously 45 min before the subconvulsive dose of PTZ (30 mg/kg, i.p) provoked dose-dependent clonic-tonic seizures (30 to 100%) and mortality in mice. At 300 g/kg, s.c., misoprostol pretreatment significantly (p < 0.05) lowered the onset latency to first convulsion as well as the latency to mortality induced by a convulsive dose of PTZ (60 mg/kg, i.p.). At this dose misoprostol was found to lower the CD50 and Ld50 values for PTZ by 21% and 36% respectively. The results suggest that prostaglandins are likely to lower the threshold for convulsions.
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