Lipopolysaccharide retards development of amygdala kindling but does not affect fully-kindled seizures in rats

Sayyah, Mohammad; Najafabadi, Iraj Toubeihaye; Beheshti, Siamak; Majzoob, Sayeh

doi:10.1016/j.eplepsyres.2003.11.002

Cited by 22 publications

(14 citation statements)

References 35 publications

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“…Furthermore, we observed a trend toward reduced seizure activity in LPS preconditioned mice, similarly to what other groups have reported (Sayyah et al, 2003, Akarsu et al, 2006, Arican et al, 2006, Dmowska et al, 2010. These data would suggest that LPS activated microglia were providing some protection to the hippocampus, perhaps by controlling the spread of seizure activity.…”

Section: A Functional Role For Microglia In Seizures: the 'Bad' And Tsupporting

confidence: 75%

“…There are a few examples in the literature where preconditioning microglia with LPS modulates seizures including our own, and this will be discussed in more detail in the next section (Sayyah et al, 2003, Akarsu et al, 2006, Arican et al, 2006, Dmowska et al, 2010, Mirrione et al, 2010, Yang et al, 2010a. One mechanism that may contribute to the positive effects attributed to LPS preconditioning is through enhanced neurotrophin release (Nakajima et al, 2001a).…”

Section: Wwwintechopencommentioning

confidence: 99%

“…In one study, LPS administration prior to pentylenetetrazole (PTZ)-induced seizures was beneficial by increasing plasma levels of NO and IL-6, which reduced blood brain barrier permeability (Arican et al, 2006). In kindling, LPS was inhibitory but only when it was administered daily for 16 days, as it blunted the acquisition of kindled behavioral seizures (Sayyah et al, 2003). Neuronal protection from cell death in hippocampal CA1, CA3 and DG was observed with LPS preconditioning 72 hours prior to seizure induction, although seizure behavior was not affected at this low dose of LPS (Dmowska et al, 2010).…”

Section: A Functional Role For Microglia In Seizures: the 'Bad' And Tmentioning

confidence: 99%

See 2 more Smart Citations

A Functional Role for Microglia in Epilepsy

Mirrione¹,

Tsirka²

2011

Clinical and Genetic Aspects of Epilepsy

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Section: A Functional Role For Microglia In Seizures: the 'Bad' And Tsupporting

confidence: 75%

Section: Wwwintechopencommentioning

confidence: 99%

Section: A Functional Role For Microglia In Seizures: the 'Bad' And Tmentioning

confidence: 99%

See 1 more Smart Citation

A Functional Role for Microglia in Epilepsy

Mirrione¹,

Tsirka²

2011

Clinical and Genetic Aspects of Epilepsy

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“…The CD40-CD40L pathway seems to be involved in inflammatory responses implicated in the pathophysiology and progression of various autoimmune and inflammatory disorders (30)(31)(32)(33). When microglial cells are exposed to proinflammatory mediators, the expression of CD40 is rapidly upregulated (11,34,35).…”

Section: Discussionmentioning

confidence: 99%

“…Activated microglia release compounds such as glutamate, free radicals, proteases, cytokines, leukotrienes and nitric oxide (NO) that could contribute to brain dysfunction (31,40). This can be further aggravated by the dysfunction of the BBB that is implicated in the pathogenesis of SAE (41).…”

Section: Discussionmentioning

confidence: 99%

CD40-CD40 Ligand Pathway Is a Major Component of Acute Neuroinflammation and Contributes to Long-term Cognitive Dysfunction after Sepsis

Michels

Danieslki

Vieira

et al. 2015

Mol Med

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Sepsis-associated encephalopathy (SAE) is associated with an increased rate of morbidity and mortality. It is not understood what the exact mechanism is for the brain dysfunction that occurs in septic patients, but brain inflammation and oxidative stress are a possible theory. Such events can occur through the alteration of molecules that perpetuate the inflammatory response. Thus, it is possible to postulate that CD40 may be involved in this process. The aim of this work is to evaluate the role of CD40-CD40L pathway activation in brain dysfunction associated with sepsis in an animal model. Microglia activation induces the upregulation of CD40-CD40L, both in vitro and in vivo. The inhibition of microglia activation decreases levels of CD40-CD40L in the brain and decreases brain inflammation, oxidative damage and blood brain barrier dysfunction. Despite this, anti-CD40 treatment does not improve mortality in this model. However, it is able to improve long-term cognitive impairment in sepsis survivors. In conclusion, there is a major involvement of the CD40-CD40L signaling pathway in long-term brain dysfunction in an animal model of sepsis.

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The investigation of the molecular changes during lipopolysaccharide‐induced systemic inflammation on rat hippocampus by using FTIR spectroscopy

Cakmak‐Arslan,

Kaya,

Mamuk

et al. 2024

Journal of Biophotonics

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The aim of this study is to reveal the molecular changes accompanying the neuronal hyper‐excitability during lipopolysaccharide (LPS)‐induced systemic inflammation on rat hippocampus using Fourier transform infrared (FTIR) spectroscopy. For this aim, the body temperature of Wistar albino rats administered LPS or saline was recorded by radiotelemetry. The animals were decapitated when their body temperature began to decrease by 0.5°C after LPS treatment and the hippocampi of them were examined by FTIR spectroscopy. The results indicated that systemic inflammation caused lipid peroxidation, an increase in the amounts of lipids, proteins and nucleic acids, a decrease in membrane order, an increase in membrane dynamics and changes in the secondary structure of proteins. Principal component analysis successfully separated control and LPS‐treated groups. In conclusion, significant structural, compositional and functional alterations occur in the hippocampus during systemic inflammation and these changes may have specific characteristics which can lead to neuronal hyper‐excitability.

show abstract

Lipopolysaccharide retards development of amygdala kindling but does not affect fully-kindled seizures in rats

Cited by 22 publications

References 35 publications

A Functional Role for Microglia in Epilepsy

A Functional Role for Microglia in Epilepsy

CD40-CD40 Ligand Pathway Is a Major Component of Acute Neuroinflammation and Contributes to Long-term Cognitive Dysfunction after Sepsis

The investigation of the molecular changes during lipopolysaccharide‐induced systemic inflammation on rat hippocampus by using FTIR spectroscopy

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