Mielopatias: comportamento das células e proteínas do líquido cefalorraqueano

Abstract

Data on cerebrospinal fluid (CSF) cells and proteins (total proteins and gamma globulins content) are reviewed in 287 patients with myelopathies. Clinical data on these patients were reported. Results obtained are distributed according to diagnoses and to time of disease (tables 1 and 2). Informations obtained through the study show that signalization of CSF system is related to the episode responsible by the disease, when the episode is singular. Repeated episodes or a progressive evolution are more apt to produce a maintained signalization of CSF cyto-protein dual. In this way data on infectious myelopathies, multiple sclerosis and neuromyelitis optica are compared to those found in post-vaccination, post-infection and post-intoxication myelopathies, as well as to those found in B-12 deficiency and myelopathies of vascular origin. Primary myelitis are evaluated in report to this comparison. It is shown that changes in the CSF cyto-protein dual are more related to those found in multiple sclerosis and neuromyelitis optica when chronic primary myelitis is considered. In acute and sub-acute primary myelitis they are related to those found in post-vaccination, post-infection and post-intoxication myelopathies.

Afecções desmielinizantes e citoproteinograma do líquido cefalorraqueano

“…Revisão sobre mielopatias de etiologia diversa 8 permitiu apontar certas características em comum da resposta do dual citoproteico do líquido cefalorraqueano (LCR) 7 . Essas características obedecem a determinado padrão, embora variem na sua intensidade conforme a etiologia e os mecanismos fisiopatológicos envolvidos.…”