Acoustic Radiation Force Impulse Is Equivalent to Liver Biopsy to Evaluate Liver Fibrosis in Patients With Chronic Hepatitis C and Nonalcoholic Fatty Liver Disease

Guerra, J.A.; Trippia, Marcus Adriano; Pissaia, Alcindo; Teixeira, Bernardo Corrêa de Almeida; Ivantes, Claudia Alexandra Pontes

doi:10.1590/s0004-28032015000300015

Cited by 9 publications

(6 citation statements)

References 19 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority of published studies support the higher accuracy of non-invasive methods in the detection of more advanced fibrosis (32)(33)(34)(35). The present study mostly included patients with non-advanced stages of fibrosis, with more than 80% of patients having stage 2 fibrosis or lower.…”

Section: Fibrosismentioning

confidence: 77%

Liver Fibrosis Assessment Using Transient Elastography by FibroScan and Shear Wave Elastography by Sonography: A Comparative Cross-sectional Study in an Outpatient Liver Clinic

et al. 2021

View full text Add to dashboard Cite

Background: Non-alcoholic fatty liver disease (NAFLD) is the second most common cause of liver transplantation in the United States, with a continuously growing prevalence. There are several non-invasive methods to detect liver fibrosis, which is defined as the accumulation of extracellular matrix proteins, particularly collagens. It is most commonly associated with chronic liver diseases, such as NAFLD. Objectives: This study aimed to investigate the concordance between transient elastography (TE) and shear wave elastography (SWE) for liver fibrosis staging and also to examine the congruence between the controlled attenuation parameter (CAP) and the B-mode hepatorenal ratio for hepatic steatosis grading in patients with NAFLD. Materials and Methods: In this cross-sectional study conducted during March 2018 - 2019, NAFLD patients, referred to the liver clinic of our center for the non-invasive assessment of hepatic fibrosis, were enrolled. However, patients with sonographic features of cirrhosis, multiple hepatic masses, or moderate to large ascites were excluded; also, patients who were uncooperative during the tests were excluded. Measurements obtained by different tools were recorded. Kolmogorov-Smirnov test, Chi-square test, independent t-test, or Mann-Whitney tests, as well as Pearson’s correlation coefficient test, were used to analyze the data. Results: Sixty-five patients (male-to-female ratio, 1:13), with a median age of 47 years, were included in the study. The tools for assessing fibrosis (r = 0.9538, 95% CI: 0.9252 - 0.9717, P < 0.0001) and steatosis (r = 0.429, 95% CI: 0.2048 - 0.6104, P < 0.0001) were perfectly and moderately correlated, respectively. Sex, age, and body mass index (BMI) did not affect the results. Conclusion: The two elastography modalities showed a strong correlation for fibrosis staging in our study population. Also, the CAP and B-mode hepatorenal ratio were moderately correlated for grading hepatosteatosis. Overall, selection of the best assessment method among the studied modalities depends on factors other than internal validity.

show abstract

Section: Fibrosismentioning

confidence: 77%

Liver Fibrosis Assessment Using Transient Elastography by FibroScan and Shear Wave Elastography by Sonography: A Comparative Cross-sectional Study in an Outpatient Liver Clinic

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Liver stiffness measurements were performed on the same day, after measurement of the hepatorenal index, using the same single ultrasound machine (S2000 HELX; Siemens, Erlangen, Germany) with an acoustic radiation force impulse point shear wave in liver The group with advanced liver fibrosis was defined as having a shear wave velocity � 1.78 m/s based on the study by Masato et al [20], in which only patients with NAFLD with the same ultrasound model as that used in our study were included. The defined cutoff is more rigorous than those described in a local population [28] and in the recent update consensus from the Society of Radiologists in Ultrasound [29], which includes patients with chronic viral hepatitis. At least eight shear wave velocity measurements with an interquartile range of < 0.15 m/s were recorded [24].…”

Section: Plos Onementioning

confidence: 99%

Hepatorenal index for grading liver steatosis with concomitant fibrosis

et al. 2021

View full text Add to dashboard Cite

Introduction Ultrasonography is widely used as the first tool to evaluate fatty liver disease, and the hepatorenal index is a semi-quantitative method that improves its performance. Fibrosis can co-exist with steatosis or even replace it during disease progression. This study aimed to evaluate the influence of fibrosis on the measurement of steatosis using the hepatorenal index. Materials and methods This cross-sectional study included 89 patients with nonalcoholic fatty liver disease and in whom liver fibrosis was determined by ultrasound elastography. The Pearson’s correlation coefficient was used to compare between the results of the sonographic hepatorenal index and the quantification of steatosis using magnetic resonance spectroscopy as well the accuracy of detecting moderate to severe steatosis using sonography in two groups of patients: (A) without advanced fibrosis and (B) with advanced fibrosis. Advanced fibrosis was defined as a shear wave speed ≥ 1.78 m/s on ultrasound elastography. We calculated the area under the curve (AUC-ROC) to detect the ability of the hepatorenal index to differentiate light from moderate to severe steatosis in both groups. Moderate to severe steatosis was defined as a fat fraction > 15% on the magnetic resonance spectroscopy. The intra-observer variability was assessed using the Bland-Altman plot. Results Among patients, the mean age was 54.6 years and 59.6% were women, 50.6% had a body mass index ≥ 30 kg/m2, 29.2% had moderate to severe steatosis, and 27.2% had advanced fibrosis. There was a correlation between steatosis grading by ultrasonography and magnetic resonance in group A (0.73; P < 0.001), but not in Group B (0.33; P = 0.058). The AUC-ROC for detecting a steatosis fraction ≥ 15% was 0.90 and 0.74 in group A and group B, respectively. The intra-observer variability for the hepatorenal index measurements was not significant (-0.036; P = 0.242). Conclusion The hepatorenal index is not appropriate for estimating steatosis in livers with advanced fibrosis.

show abstract

“…Additional tests are based on demographic data and risk factors (BARBUTI et al, 2020;FU et al, 2017;JIŘÍ et al, 2016;LURIE et al, 2015;MACHADO et al, 2020). (GUERRA et al, 2015;HONAR et al, 2015;RAMALHO et al, 2017;SCHMILLEVITCH et al, 2016).…”

Section: Recent Advances In the Diagnosis Of Liver Cirrhosismentioning

confidence: 99%

Advances in the diagnosis and therapy of liver cirrhosis: a systematic review / Avanços no diagnóstico e terapia da cirrose hepática: uma revisão sistemática

Vasconcelos¹,

Oliveira²,

Barbosa³

et al. 2021

BJDV

View full text Add to dashboard Cite

Hepatic cirrhosis (HC) is a diffuse pathophysiological state of the liver considered to be the end-stage of several liver injuries. It is essential to highlight the need to implement new diagnostic and treatment methods to contain subsequent damage to liver cirrhosis, so that we can better understand the pathophysiological process of the disease and obtain better therapeutic results. Thus, this study aimed to identify advances in diagnostic methods and treatments for liver cirrhosis. This is a systematic literature review study, conducted by searching the descriptors “Liver cirrhosis”, “Alcoholic liver cirrhosis”, “Liver fibrosis” and “Liver”, in the databases: Scielo- Scientific Electronic Library Online, Lilacs - Latin American and Caribbean Center on Health Sciences Information, NIH-NCBI-Pubmed- National Center for Biotechnological Information – National Library of Medicine, following a search strategy according to descriptors in Portuguese and English, years 2015 to 2021. At the end of the search with the descriptors, 835 articles were found in the databases, of which 88 were in the Scielo platform, 286 in Lilacs and 461 in Pubmed. After the three selection steps, 811 articles were excluded and 23 articles that met the inclusion and exclusion criteria were selected for analysis. Based on this systematic review, it is pointed out that there has been a lot of development regarding the diagnosis and treatment of cirrhosis that, for many years, required scientific evidence to combat morbidity and mortality and reverse the condition of liver cirrhosis.

show abstract

Acoustic Radiation Force Impulse Is Equivalent to Liver Biopsy to Evaluate Liver Fibrosis in Patients With Chronic Hepatitis C and Nonalcoholic Fatty Liver Disease

Abstract: Acoustic radiation force impulse is a method with good accuracy to distinguish initial fibrosis from advanced fibrosis in hepatitis C virus and nonalcoholic fatty liver disease and can replace biopsy in most cases.

Cited by 9 publications

References 19 publications

Liver Fibrosis Assessment Using Transient Elastography by FibroScan and Shear Wave Elastography by Sonography: A Comparative Cross-sectional Study in an Outpatient Liver Clinic

Liver Fibrosis Assessment Using Transient Elastography by FibroScan and Shear Wave Elastography by Sonography: A Comparative Cross-sectional Study in an Outpatient Liver Clinic

Hepatorenal index for grading liver steatosis with concomitant fibrosis

Advances in the diagnosis and therapy of liver cirrhosis: a systematic review / Avanços no diagnóstico e terapia da cirrose hepática: uma revisão sistemática

Contact Info

Product

Resources

About