Seroprevalence of Helicobacter pylori in patients with colon adenomas in a brazilian university hospital

Abstract

-Context -The association between Helicobacter pylori infection and colon neoplasia has been the subject of recent investigations which have produced controversial results. Objective -To evaluate the prevalence of H. pylori infection in patients with colonic adenomas and also in patients whose colonoscopy exams were normal. Methods -After colonoscopy, the individuals were distributed into two groups: patients with colon adenomas (cases) and patients whose colons were normal (controls). The groups were similar regarding age and gender. The individuals of both groups were subjected to a dosage of IgG antibody against H. pylori. The dosage was applied according to the solid phase, chemiluminescent immunometric assay. The chi-square test was used to analyze the data. Results -There were 30 men and 64 women in each group (94 cases and 94 controls). The mean age of the cases was 59.79 ± 12.25 years and that of the controls was 58.98 ± 11.55 years. The H. pylori serology was positive for 66 (70.21%) of the cases and for 51 (54.25%) of the controls. There was a significant difference (P = 0.024). The odds ratio was 1.98 (CI 95%, 0.82-3.15). The prevalence of H. pylori in cases and controls according to gender, histological type and location of the colon lesions showed a significant difference only among women (P = 0.03), among patients with tubular adenomas (P = 0.03), and in those with distal adenomas (P = 0.038). Conclusion -There is a positive association between H. pylori infection and colonic adenomas. This association is more evident in women, especially for tubular adenomas and distal colonic location. HEADINGS -Helicobacter pylori. Adenoma. Colonic neoplasms. Helicobacter infections.

Helicobacter pylori Infection and the Risk of Colorectal Adenoma and Adenocarcinoma: an Updated Meta-analysis of Different Testing Methods

“…In all, six studies clarified sex-based differences. Buso et al (2009) found that female subjects infected with H. pylori had a significantly stronger risk of colorectal tumor development. Fujimori et al (2005) and Jones et al (2007) found that the OR for colorectal adenocarcinoma in H. pylori-infected female subjects was higher than that in males, but this result was not statistically significant.…”

“…Zhang et al (2012) showed the elevation of risk to be essentially confined to left-sided colorectal cancer, with an odds ratio of 1.22 (95% CI 1.02, 1.45); this suggests that H. pylori infection may be associated with a small yet relevant risk increase in the left colorectal region. Buso et al (Buso et al, 2009) and Inoue et al (2011) showed that distal adenoma risk was significantly increased in the presence of H. pylori infection. Meanwhile, Inoue et al (2011) found that the proximal adenoma risk increased in a stepwise manner with the presence and progression of H. pylori-related chronic gastritis, showing a maximal and significant increase in the presence of H. pylori CagA (crude OR 4.51, 95% CI 1.43-14.2).…”

Role of Bacteria in Oncogenesis

“…Because H. pylori increases gastrin levels, an association between H. pylori infection and colorectal neoplasia has frequently been sought. Although the findings are still debated, H. pylori infection appears to increase the risk of colonic adenomas, particularly in the more distal colon (31,36,85,169,223). The postulated mechanism is similar to that derived for gastric cancer: H. pylori-induced hypergastrinemia influences precancerous lesions toward malignant transformation.…”

Clinical Features of Infants Hospitalized for 2009 Pandemic Influenza A (H1N1) in Japan

“…[3][4][5][6][7] Previous studies have suggested that HP infection may be a risk factor for the development of colorectal polyps and colorectal cancer, similar to its role in gastric carcinoma and lymphoma. [8][9][10][11] However, this association is controversial because other researchers found no relationship between colonic neoplasia and HP infection. 12,13 The seroprevalence of HP in patients with colorectal polyps and colorectal carcinoma can lead to ambiguous results because antibodies can be detectable for a long period after the bacteria have ceased to colonize the gut.…”