CA72-4 antigen levels in serum and peritoneal washing in gastric cancer: correlation with morphological aspects of neoplasia

Abstract

-Background -Determining levels of tumor markers in peritoneal washing enables likelihood of peritoneal recurrence to be ascertained in patients with high marker levels, thereby allowing provision of more accurate adjuvant treatment and postoperative follow up. Aim -To analyze the relationship between levels of tumor marker CA72-4 in serum and peritoneal washing, and morphological aspects of gastric carcinoma. Method -This study analyzed 32 consecutively-operated patients with gastric carcinoma, who underwent subtotal, total or palliative gastrectomy. The variables studied were CA72-4 levels in serum and peritoneal washing, lesion site, stage, degree of cell differentiation, operation performed, and number of extirpated and involvement lymph nodes. Of the 32 patient sample, 21 (65.6%) were male and 11 (34.4%) female. Mean age was 62.6 ± 14.2 years (29 to 91 years). Following anesthetic induction, peripherical venous blood was collected through percutaneous punction of an upper limb vein. After the procedure, 50 mL of physiologic solution at 37ºC was introduced into the cul-de-sac. A 10 mL volume of this liquid was aspirated from the cavity and the peritoneal washing tested for CA72-4 levels. Normal values for CA72-4 levels in serum were considered ≤7 U/mL and high levels as >7U/mL, whilst for the peritoneal washing normal levels were ≤0.61 U/mL, and abnormal >0.61 U/mL. Results -Mean pre-operative serum levels for CA72-4 were 6.55 U/mL ± 15.30 (0.3 to 75.30 U/mL) whilst the mean level of CA72-4 in peritoneal washing was 8.50 U/mL ± 26.72 (0.3 to 142.00 U/mL); correlation between these levels was significant. Lymph nodes involvement by the gastric carcinoma correlated significantly with higher CA72-4 levels in both serum and peritoneal wash. There was no statistically significant correlation between serum level of CA72-4 and invasion into serosa by the gastric carcinoma. There was however, significant correlation between peritoneal washing levels of CA72-4 and involvement of serosa by gastric carcinoma. There was also a significant correlation between more advanced stages of gastric carcinoma and higher levels of CA72-4 in the peritoneal washing, although serum levels of CA72-4 and more advanced stage of gastric neoplasia showed no significant correlation. Degrees of cellular differentiation in the gastric carcinoma did not differ significantly with CA72-4 levels in serum or peritoneal washing. Conclusions -High levels of CA72-4 in peritoneal washing correlated significantly with lymph node metastasis and serosa involvement by the neoplasia, and also with more advanced stage of gastric carcinoma. The levels of CA72-4 in the blood correlated significantly with lymph node involvement by the gastric carcinoma, but not with serosa invasion or more advanced stage of neoplasia.

Diagnostic role of carbohydrate antigen 72‐4 for gastrointestinal malignancy screening in Chinese patients: A prospective study

“…noted that the chemo‐sensitivity of GC patients was not associated with pretreatment CA72‐4 levels . Although elevated concentration of CA72‐4 in the peritoneal washes of GC patients was closely associated with the involvement of the lymph nodes, serosa organ invasion and advanced disease, serum CA72‐4 levels were not closely linked to these phenomena . All results of the studies mentioned above are in agreement with ours.…”

WITHDRAWN: Diagnostic performance of carbohydrate antigen 72-4 for gastrointestinal malignancy screening in Chinese patients: a prospective study

“…Yoon et al declared that chemo-sensitivity of GC patients was not associated with pretreatment CA72-4 levels [23]. Although the elevated concentrations of CA72-4 in the peritoneal washing of GC patients were closely associated with the involvement of lymph nodes, serosa organ invasion and more advanced condition of disease, levels of CA72-4 in serum did not show a close link as mentioned above [24]. All results of researches mentioned above are in agreement with ours.…”

Over-expression of metastasis-associated in colon cancer-1 (MACC1) associates with better prognosis of gastric cancer patients

“…And it is difficult to give proper personalized treatment to each patient and to identify the patients with cancer relapse and metastasis at the earliest possible time. There are many factors that may affect the prognosis [1] , and serum biomarkers CEA [2][3][4] , CA19-9 [5][6][7] , CA72-4 [8][9][10][11] , CA242 [12] and a combination of the all [13,14] are widely used prognostic factors. When anastomotic recurrence or distant metastasis is revealed by assistance of tumor markers or medical imaging, gastric cancer can not usually be cured by further surgery.…”