Over-expression of metastasis-associated in colon cancer-1 (MACC1) associates with better prognosis of gastric cancer patients

Ge, Shaohua; Wu, Xiaojiang; Wang, Xiaohong; Xing, Xiaofang; Zhang, Lianhai; Zhu, Yubing; Du, Hong; Dong, Bin; Ying, Hanjie; Ji, Jiafu

doi:10.1007/s11670-011-0153-9

Cited by 22 publications

(25 citation statements)

References 31 publications

(34 reference statements)

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“…Four eligible trials had to be excluded from the meta-analysis because they did not provide sufficient data on survival [40]–[43]. Among the four excluded studies, two of these studies were not statistically significant [40], [41]. It is known that this type of study is less frequently published or, if they are, with less detailed results, making them less assessable.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of MET Amplification and Expression in Gastric Cancer: A Systematic Review with Meta-Analysis

et al. 2014

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Background and AimsMET, the hepatocyte growth factor receptor, is a receptor tyrosine kinase overexpressed and activated in a subset of gastric cancer. Several studies investigated the relationship between MET amplification and expression with the clinical outcome in patients with gastric cancer, but yielded conflicting results. We performed a systematic review and meta-analysis to determine the influence of MET amplification and expression on prognosis in gastric cancer.MethodsMEDLINE and EMBASE were searched for studies that explored the association between MET amplification and expression with survival in patients with gastric cancer up to 1 April, 2013. Data of individual hazard ratios (HRs) and 95% confidence intervals (CIs) for meta-analyses were extracted from the publications and combined in pooled HRs.ResultsFourteen studies involving 2,258 patients with gastric cancer were included. It was suggested that MET overexpression had an unfavorable impact on survival of patients with gastric cancer, with HRs (95% CIs) of 2.57 (95% CI: 1.97–3.35) overall, 2.82 (95% CI: 1.86–4.27) among studies using amplification for measure scale of MET and 2.42 (95% CI: 1.66–3.54) for expression. The magnitude of association was reduced whereas remained statistically significant in high quality studies or in larger sample size studies and corresponding HRs were 2.18(1.76, 2.70) and 2.35(1.93, 2.87), respectively, without significant heterogeneity.ConclusionThe findings from present study indicated that higher MET gene amplification and expression in gastric cancer was an indicator of poor prognosis.

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Section: Discussionmentioning

confidence: 99%

Prognostic Significance of MET Amplification and Expression in Gastric Cancer: A Systematic Review with Meta-Analysis

et al. 2014

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“…Metastasis associated in colon cancer-1 (MACC1) is an oncogene, and its overexpression has been associated with the development and progression of numerous tumors, including gastric carcinoma (11), hepatocellular carcinoma (12), lung adenocarcinoma (13), esophageal cancer (14), glioma (15) and breast cancer (16). Zhen et al (17) demonstrated that MACC1 overexpression resulted in the upregulation of Met and β-catenin, as well as its downstream genes, including c-Myc, cyclin D1 and matrix metallopeptidase 9, and the upstream gene phospho-glycogen synthase kinase 3β (Ser9).…”

Section: Introductionmentioning

confidence: 99%

miR-433 reduces cell viability and promotes cell apoptosis by regulating MACC1 in colorectal cancer

Mao¹,

Wang²,

Miao³

et al. 2016

Oncology Letters

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MicroRNAs (miRNAs) are reported to have important roles in regulating the progression of numerous human cancers, although little is known regarding the role of miRNAs in colorectal cancer. The present study aimed to investigate the role of microRNA-433 (miR-433) in colorectal cancer. The expression levels of miR-433 and its target gene metastasis associated in colon cancer-1 (MACC1) in colorectal cancer tissues were evaluated using reverse transcription-quantitative polymerase chain reaction and western blotting. Furthermore, flow cytometry and MTT assays were used to examine the apoptosis, cell cycle distribution and viability of human colorectal cancer cells, and luciferase reporter and western blot assays were performed to verify the regulatory mechanism of miR-433 on MACC1. In addition, caspase-3 and caspase-9 expression were examined using western blotting. It was demonstrated that miR-433 expression was downregulated in colorectal cancer tissues and cell lines. Artificial upregulation of miR-433 in colorectal cancer cell lines using miR-433 mimics revealed that upregulation of miR-433 was able to reduce the viability and promote the apoptosis of colorectal cancer cells by downregulating MACC1. Taken together, these results suggested that miR-433 may have an important role in the pathogenesis of colorectal cancer.

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“…The published frequency of EGFR positivity/overexpression by IHC in GC varies between 2% and 38%, 15,55-57 whereas of c-MET varies between 9% and 83%. 23,[28][29][30][31][32][33][34][58][59][60] The varied reported range of EGFR and c-MET overexpression likely account from differing methodologies (TMA vs. whole section, biopsy vs. resection, primary tumor vs. metastasis), lack of standardized interpretation methods and possible geographic differences, with a predominance of studies investigating Asian populations.…”

Section: Discussionmentioning

confidence: 99%

“…Despite varied methodologies and antibodies, most studies have reported c-MET positivity/ overexpression as a negative prognostic factor. 29,31,32,[64][65][66][67][68] Only 2 other studies have reported no c-MET prognostic significance, 30,69 and 1 study has reported it as a positive prognostic factor. 37 It is possible that with a larger patient series, the trend we saw toward negative survival would achieve statistical significance.…”

Section: Discussionmentioning

confidence: 99%

“…8,17,[20][21][22][23][24][25] Previous reports describe MET amplification in approximately 20% of GC, [23][24][25][26][27] whereas c-MET protein overexpression by immunohistochemistry (IHC) varies markedly in different reports between 9% and 83% of GC. 23,[28][29][30][31][32][33][34] There is crosstalk between EGFR and c-MET that reportedly enhances cell tumorgenicity in several cancer cell types, both in vitro and in vivo. 28,35,36 In vitro studies have shown that EGFR and c-MET receptors are interdependent and can be transactivated by stimulation of a G protein-coupled receptor ligand in gastric cell lines.…”

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confidence: 99%

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The Prognostic Significance of c-MET and EGFR Overexpression in Resected Gastric Adenocarcinomas

Paliga

Marginean

Tessier‐Cloutier

et al. 2017

American Journal of Clinical Oncology

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Over-expression of metastasis-associated in colon cancer-1 (MACC1) associates with better prognosis of gastric cancer patients

Abstract: MACC1 over-expression implies better survival and may be an independent prognostic factor for gastric cancer in Chinese patients.

Cited by 22 publications

References 31 publications

Prognostic Significance of MET Amplification and Expression in Gastric Cancer: A Systematic Review with Meta-Analysis

Prognostic Significance of MET Amplification and Expression in Gastric Cancer: A Systematic Review with Meta-Analysis

miR-433 reduces cell viability and promotes cell apoptosis by regulating MACC1 in colorectal cancer

The Prognostic Significance of c-MET and EGFR Overexpression in Resected Gastric Adenocarcinomas

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