Epidemiologic Aspects of Inflammatory Bowel Disease in the Western Region of Minas Gerais State

Abstract

BACKGROUND: Crohn’s disease (CD) and ulcerative colitis (UC), two of the main inflammatory bowel diseases (IBD), have been increasingly diagnosed in South America. Although IBD have been intensively studied in the last years, epidemiologic data in Brazil are scarce. OBJECTIVE: To study the clinical and epidemiologic profile of IBD patients treated in the Clinical Hospital of the Federal University of Uberlândia from 1999 to 2014. METHODS: We performed a retrospective study of the medical records of patients diagnosed with IBD, according to the international classification of diseases (ICD) - ICD K50 for CD and ICD K51 for UC - confirmed by endoscopic examination in the case of both diseases. We analyzed the following variables: age; sex; ethnicity; smoking habit; primary diagnosis; site of disease manifestation; main clinical manifestations; IBD-related complications; extraintestinal manifestations; and established drug and/or surgical treatment. RESULTS: We evaluated 183 IBD cases (91 UC and 92 CD cases). The estimated prevalence rate of UC was 15.06/100.000 inhabitants and of CD was 15.23/100.000. The CU and CD female to male incidence ratios were 1.7 and 1.8, respectively. The average age of patients diagnosed with UC was 39.4 years and of those diagnosed with CD was 31.1 years. White-skinned people were the most affected by UC (66.0%) and CD (69.0%). Few patients were submitted to surgical procedures as treatment alternative. CONCLUSION: The estimated prevalence of IBD in this population was low compared to that of populations of North America, but high compared to that of other regions considered to present low incidence, such as some Asian and Latin American countries.

A Multicentre Study of the Clinical and Epidemiological Profile of Inflammatory Bowel Disease in Northeast Brazil

“…Temporal analysis based on the diagnosis of new cases in healthcare units has been used as an indirect assessment of case increases in a region. 18–21 In Brazil, this progressive increase in newly diagnosed cases over the years has been reported in studies from the southeast and northeast regions, but IBD-related data for the Northeast region are limited. 18 , 21 , 22 A trend of increasing newly diagnosed cases over the years in outpatient units has been reported in other Latin American and Asian countries, historically considered to have low prevalence of IBD.…”

“… 18–21 In Brazil, this progressive increase in newly diagnosed cases over the years has been reported in studies from the southeast and northeast regions, but IBD-related data for the Northeast region are limited. 18 , 21 , 22 A trend of increasing newly diagnosed cases over the years in outpatient units has been reported in other Latin American and Asian countries, historically considered to have low prevalence of IBD. 19 , 20 Despite the methodology not allowing for population extrapolations, this increase has been described using other methodologies employed in Brazil, reinforcing that the rise in newly diagnosed cases in healthcare units may reflect the increase in population cases.…”

“…These data are similar to those described in Latin American countries and some Brazilian states. 17 , 18 , 29–32 …”

“…These findings are similar to those reported in European countries and the USA, as well as in other regions of Brazil. 18 , 19 , 31 However, different patterns have been described in Asia. For example, in a meta-analysis of a Chinese population, Li et al found that 64% of UC cases were diagnosed in patients over the age of 40.…”

Dificuldade Terapêutica Da Diferenciação Clínica Da Doença De Crohn E Tuberculose Intestinal

“…Uma das principais DII é a doença de Crohn (DC), considerada incurável, recorrente e com grande repercussão na qualidade de vida do indivíduo é, portanto, caracterizada com uma problemática no cenário da saúde pública mundial. (MARTINS, et al, 2021).…”