Manipulation of the Intestinal Microbiota: The Medicine Revolution of the 21st Century

Quilici, Flavio Antônio

doi:10.1590/s0004-2803.2017v54n2-01

Cited by 2 publications

(1 citation statement)

References 8 publications

(2 reference statements)

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“…The gut microbiota participates in various physiological activities, such as digesting and absorbing nutrients, collecting energy, metabolizing dietary component, regulating immunity and processing host or microorganism-derived chemicals 3 . With the in-depth exploration in the physiopathological mechanism of CRC, gut microbiota disorder has attracted more attention as one of its pathogenesis mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Characteristics and differences of gut microbiota in patients with different Traditional Chinese Medicine Syndromes of Colorectal Cancer and normal population

Wang¹,

Ding²,

Sun³

et al. 2020

J. Cancer

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Colorectal cancer (CRC) is considered to be closely associated with alteration of intestinal microorganisms. The purpose of present study was to investigate the distribution of gut microbiota in the distinction of microbiota dysbiosis between two disease syndromes called Zheng-Qi-Kui-Xu(ZQKX) and Xie-Du-Yong-Sheng (XDYS). First, From February 2019 to June 2019, CRC patients presenting to the oncology department of Zhejiang Province Hospital of TCM who met the established inclusion and exclusion criteria were enrolled in this prospective study. After fresh stool specimens of healthy volunteers and CRC patients with ZQKX or XDYS syndorme were collected, 16S rRNA gene amplification and sequencing could be used to identify the diversity and abundance of gut microbiota among groups. The results demonstrated that the composition of the microbiota in general control group was superior to those in experimental groups. At the phylum level, a significantly increased abundance of Bacteroides was observed in healthy volunteers. At the class level, Erysipelothrix decreased while Lactobacillaceae showed increased abundance in the ZQKX group compared to healthy controls. At the family level, Prevotella Shan and Collins decreased while Streptococcus significantly increased in patients with XDYS syndrome compared to healthy subjects. Five differential taxa were identified between ZQKX and XDYS syndromes. We suggest that the gut microbiota contributes to the distinction between the two TCM syndromes of CRC, which can be used as a biological basis of TCM syndrome differentiation treatment in CRC.

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Section: Introductionmentioning

confidence: 99%

Characteristics and differences of gut microbiota in patients with different Traditional Chinese Medicine Syndromes of Colorectal Cancer and normal population

Wang¹,

Ding²,

Sun³

et al. 2020

J. Cancer

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Transplantation of fecal microbiota or probiotics?

Никонов¹,

Аксенов²

2017

Dok. gastroenterol.

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As a result of recent progress in the development of the molecular genetics methods for the evaluation of the intestinal microbiome status, there are increasingly more evidence becoming available during the last evidences that the commensal bacteria exert a great influence on the wellbeing of healthy people, the state of intestinal microbiota, and the development of gastrointestinal diseases. The majority of the literature publications concerning the application of fecal microbiota transplantation (FMT) describe series of clinical cases of Clostridium difficile infection, inflammatory bowel disease, and irritable bowel syndrome. The use of probiotics for the management of these conditions appears to be supported by a more solid evidence-based practice and find a wider range of clinical applications than FMT for the prevention and treatment of various gastrointestinal diseases associated with an infection as well as pathological processes attributable to immune disorders.

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Manipulation of the Intestinal Microbiota: The Medicine Revolution of the 21st Century

Cited by 2 publications

References 8 publications

Characteristics and differences of gut microbiota in patients with different Traditional Chinese Medicine Syndromes of Colorectal Cancer and normal population

Characteristics and differences of gut microbiota in patients with different Traditional Chinese Medicine Syndromes of Colorectal Cancer and normal population

Transplantation of fecal microbiota or probiotics?

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