Genotype Association Gstm1 Null and Gastric Cancer: Evidence-Based Meta-Analysis

Ribeiro, Rívian Xavier; Nascimento, Cícera; Silva, Antônio Márcio Teodoro Cordeiro

doi:10.1590/s0004-2803.201700000-14

Cited by 8 publications

(3 citation statements)

References 63 publications

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“…Increased cell proliferation rate, cell metastasis potential and inhibited cell apoptotic capacity were the main manifestations of the majority of malignancies ( 15 ); therefore, the present study also investigated the effects of Z38 on cell apoptosis. As demonstrated in Fig.…”

Section: Resultsmentioning

confidence: 99%

Long noncoding RNA Z38 promotes cell proliferation and metastasis and inhibits cell apoptosis in human gastric cancer

Wang

Zheng

et al. 2018

Oncol Lett

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Gastric cancer is one of the leading causes of cancer-associated mortality and has a high tendency to metastasize, making it a priority to develop novel diagnostic and treatment methods at the early stages. The present study investigated the role of a newly-discovered long non-coding RNA, Z38, in gastric cancer cell proliferation, metastasis and apoptosis. It was observed that Z38 was upregulated in tissues from patients with gastric cancer as well as in cultured gastric cancer cells. Knockdown of Z38 decreased the cell proliferative rate, as evidenced by colony formation assays and cell proliferation assays. In addition, Transwell assays and wound-healing assays demonstrated that depletion of Z38 significantly inhibited cell migration and invasion in AGS and MKN74 cells. Furthermore, a cell apoptosis assay and measurement of relative activities of related caspases revealed that depletion of Z38 increased cell apoptosis by promoting the activities of caspase-3 and caspase-9, but not that of caspase-8. Finally, western blot analysis further demonstrated the role of Z38 in the apoptosis of AGS and MKN74 cells. These results suggested that Z38 promotes cell proliferation and metastasis, and inhibits cell apoptosis in gastric cancer. Z38 may represent a novel therapeutic target for the treatment of gastric cancer in clinic.

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Section: Resultsmentioning

confidence: 99%

Long noncoding RNA Z38 promotes cell proliferation and metastasis and inhibits cell apoptosis in human gastric cancer

Wang

Zheng

et al. 2018

Oncol Lett

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“…Xavier et al, in 2017, found that Asian country people with GSTM1 --null gene were more easily to develop gastric cancer than European and American. [ 18 ] Hernández et al [ 19 ] in 2017, demonstrated that GSTM1 and GSTT1 deletion could not be regarded as a separate factor influencing the survival of lung cancer. Lee et al [ 20 ] in 2020, showed that GSTP1rs1695 polymorphism was useful for the treatment of chronic myeloid leukemia patients.…”

Section: Introductionmentioning

confidence: 99%

Effects of Glutathione S-Transferases (GSTM1, GSTT1 and GSTP1) gene variants in combination with smoking or drinking on cancers: A meta-analysis

Hu,

Li,

Huang

et al. 2024

Medicine

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Background: This meta-analysis aimed to systematically summarize the association between cancer risks and glutathione s-transferases (GSTs) among smokers and drinkers. Methods: Literature was searched through PubMed, Web of Science, CNKI, and WANFANG published from 2001 to 2022. Stata was used with fixed-effect model or random-effect model to calculate pooled odds ratios (ORs) and the 95% confidence interval (95% CI). Sensitivity and heterogeneity calculations were performed, and publication bias was analyzed by Begg and Egger’s test. Regression analysis was performed on the correlated variables about heterogeneity, and the false-positive report probabilities (FPRP) and the Bayesian False Discovery Probability (BFDP) were calculated to assess the confidence of a statistically significant association. Results: A total of 85 studies were eligible for GSTs and cancer with smoking status (19,604 cases and 23,710 controls), including 14 articles referring to drinking status (4409 cases and 5645 controls). GSTM1-null had significant associations with cancer risks (for smokers: OR = 1.347, 95% CI: 1.196–1.516, P < .001; for nonsmokers: OR = 1.423, 95% CI: 1.270–1.594, P < .001; for drinkers: OR = 1.748, 95% CI: 1.093–2.797, P = .02). GSTT1-null had significant associations with cancer risks (for smokers: OR = 1.356, 95% CI: 1.114–1.651, P = .002; for nonsmokers: OR = 1.103, 95% CI: 1.011–1.204, P = .028; for drinkers: OR = 1.423, 95% CI: 1.042–1.942, P = .026; for nondrinkers: OR = 1.458, 95% CI: 1.014–2.098, P = .042). Negative associations were found between GSTP1rs1695(AG + GG/AA) and cancer risks among nondrinkers (OR = 0.840, 95% CI: 0.711–0.985, P = .032). Conclusions: GSTM1-null and GSTT1-null might be related cancers in combination with smoking or drinking, and GSTP1rs1695 might be associated with cancers among drinkers.

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“…Table 1 (Tab. 1) (References in Table 1: Chang et al, 2014[ 1 ]; Chen et al, 2015[ 2 ]; Cheng et al, 2015[ 3 ]; Dai et al, 2015[ 4 ]; Deng et al, 2014[ 5 ]; Gong et al, 2016[ 9 ]; Han et al, 2012[ 11 ]; He et al, 2013[ 12 ]; Hua et al, 2014[ 14 ]; Jia et al, 2017[ 16 ]; Kuang et al, 2014[ 17 ]; Li et al, 2015[ 20 ]; Li et al, 2016[ 18 ]; Li et al, 2017[ 19 ]; Liang et al, 2018[ 21 ]; Liu et al, 2011[ 23 ]; Liu et al, 2011[ 24 ]; Liu et al, 2014[ 25 ]; Liu et al, 2014[ 26 ]; Lu et al, 2012[ 27 ]; Ma et al, 2013[ 29 ]; Ma et al, 2013[ 30 ]; Ma et al, 2017[ 28 ]; Mo et al, 2016[ 31 ]; Mocellin et al, 2015[ 32 ]; Namazi et al, 2018[ 35 ]; Pabalan et al, 2015[ 36 ]; Peng and Xu, 2015[ 37 ]; Qi et al, 2016[ 38 ]; Qin et al, 2017[ 39 ]; Ribeiro et al, 2017[ 41 ]; Shen et al, 2014[ 47 ]; Shi et al, 2014[ 48 ]; Shi et al, 2017[ 49 ]; Shi et al, 2018[ 50 ]; Tian et al, 2012[ 52 ]; Wang et al, 2013[ 53 ]; Wang et al, 2014[ 54 ]; Wang et al, 2015[ 56 ]; Wang et al, 2015[ 57 ]; Wang et al, 2016[ 55 ]; Wu et al, 2015[ 58 ]; Xie et al, 2017[ 59 ]; Xu et al, 2014[ 61 ]; Xu et al, 2014[ 63 ]; Xu et al, 2015[ 62 ]; Xu et al, 2018[ 60 ]; Yadav et al, 2018[ 64 ]; Yan et al, 2013[ 65 ]; Yang et al, 2014[ 66 ]; Yang et al, 2016[ 67 ]; Ye et al, 2017[ 68 ]; Yu et al, 2014[ 69 ]; Zhang et al, 2012[ 72 ]; Zhang et al, 2013[ 71 ]; Zhang et al, 2015[ 74 ]; Zhang et al,...…”

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confidence: 99%

Non-random distribution of gastric cancer susceptible loci on human chromosomes

Mahjoub

Saadat

2018

EXCLI Journal; 17:Doc802; ISSN 1611-2156

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Genotype Association Gstm1 Null and Gastric Cancer: Evidence-Based Meta-Analysis

Cited by 8 publications

References 63 publications

Long noncoding RNA Z38 promotes cell proliferation and metastasis and inhibits cell apoptosis in human gastric cancer

Long noncoding RNA Z38 promotes cell proliferation and metastasis and inhibits cell apoptosis in human gastric cancer

Effects of Glutathione S-Transferases (GSTM1, GSTT1 and GSTP1) gene variants in combination with smoking or drinking on cancers: A meta-analysis

Non-random distribution of gastric cancer susceptible loci on human chromosomes

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