Long noncoding RNA Z38 promotes cell proliferation and metastasis and inhibits cell apoptosis in human gastric cancer

Wang, Yang; Zheng, Chen; Li, Teng; Zhang, Rui; Zhang, Jiaxin; He, Qin; Sun, Zuocheng; Wang, Xinsheng

doi:10.3892/ol.2018.9343

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…CCK-8 assays are conducted to assess cancer cell proliferation abilities, and Transwell and wound healing assays are used to evaluate migration abilities (32)(33)(34)(35). To investigate the observations from the bioinformatics analyses, in vitro cell line experiments were conducted, indicated that USP19 overexpression suppressed proliferation and migration, whereas USP19 knockdown promoted proliferation and migration.…”

Section: Discussionmentioning

confidence: 99%

Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma

Fei

et al. 2020

Oncol Rep

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Ubiquitin specific peptidase 19 (USP19) is a member of the USP family and exhibits diverse roles in various biological processes, such as cell differentiation, cell cycle progression and apoptosis. There is limited knowledge regarding the role and impact of USP19 in cancer, particularly clear cell renal cell carcinoma (ccRCC). To examine the function of USP19 in ccRCC, The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases were examined to determine USP19 mRNA expression levels. USP19 mRNA levels were significantly lower in ccRCC tissues than in normal tissues. USP19 downregulation was associated with ccRCC progression and poor prognostic outcomes in TCGA cohort. Furthermore, the functional involvement of USP19 in ccRCC was examined using Cell Counting Kit-8, soft agar, Transwell and wound healing assays in vitro following overexpression or knockdown of USP19 in the Caki-1 cell line. USP19 overexpression inhibited ccRCC proliferation and migration, whereas USP19 knockdown promoted ccRCC proliferation and migration in vitro. Consistent with these results, it was further demonstrated that USP19 downregulation promoted tumor growth in vivo in a xenograft model. Mechanistically, it was found that USP19 exerted its inhibitory effect on ccRCC proliferation and migration by suppressing the activation of ERK. Collectively, the present findings identified a role for USP19 as a tumor suppressor in ccRCC and demonstrated that USP19 is a potential prognostic biomarker that could be applied in ccRCC therapy.

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Section: Discussionmentioning

confidence: 99%

Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma

Fei

et al. 2020

Oncol Rep

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“…An increasing number of recent studies have revealed that lncRNAs participate in the progression of GC by regulating metastasis and angiogenesis 11 . The ncRNAs Z38 12 , LINC01606 13 , and SNHG16 regulate cell metastasis in GC. LINC01410 14 , PVT1 15 , and MALAT1 16 contribute to the regulation of vasculogenic mimicry and angiogenesis, which can in turn aggravate GC progression.…”

Section: Introductionmentioning

confidence: 99%

LncRNA AC093818.1 accelerates gastric cancer metastasis by epigenetically promoting PDK1 expression

Long

et al. 2020

Cell Death Dis

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Gastric cancer (GC) is a highly prevalent type of metastatic tumor. The mechanisms underlying GC metastasis are poorly understood. Some long noncoding RNAs (lncRNAs) reportedly play key roles in regulating metastasis of GC. However, the biological roles of five natural antisense lncRNAs (AC093818.1, CTD-2541M15.1, BC047644, RP11-597M12.1, and RP11-40A13.1) in GC metastasis remain unclear. In this study, the expression of these lncRNAs was measured by quantitative reverse transcription-polymerase chain reaction. Migration and invasion were evaluated by wound-healing and the Transwell assay, respectively. Stable cells were injected into the tail veins of nude mice. Sections of collected lung and liver tissues were stained using hematoxylin and eosin. Protein expression was analyzed by western blot. RNA immunoprecipitation (RIP) assay was used to verify whether the STAT3 and SP1 transcription factors bound to AC093818.1 in GC cells. Expression levels of the five lncRNAs, especially AC093818.1, were significantly upregulated in metastatic GC tissues relative to those in nonmetastatic GC tissues. AC093818.1 expression was correlated with invasion, lymphatic metastasis, distal metastasis, and tumor-node-metastasis stage. AC093818.1 expression was highly sensitive and specific in the diagnosis of metastatic or nonmetastatic GC. AC093818.1 overexpression promoted GC migration and invasion in vitro and in vivo. AC093818.1 overexpression increased PDK1, p-AKT1, and p-mTOR expression levels. AC093818.1 silencing decreased these expressions. AC093818.1 bound to transcription factors STAT3 and SP1, and SP1 or STAT3 silencing could alleviated the effect of AC093818.1 overexpression. The data demonstrate that lncRNA AC093818.1 accelerates gastric cancer metastasis by epigenetically promoting PDK1 expression. LncRNA AC093818.1 may be a potential therapeutic target for metastatic GC.

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“…Knockdown of Z38 negatively influences cell proliferative rate together with the induction of apoptosis in gastric cancer in a similar way in breast cancer ( 109 ). Z38 acts through the activation of caspase 3 and 9 to initiate the apoptotic pathway ( 110 ). High expression of Z38 and its oncogenic influence makes it prognostically significant in cases of breast cancer ( 111 ).…”

Section: Interplay Of Lncrna and Trail In Breast Cancermentioning

confidence: 99%

Long non‑coding RNA regulation of TRAIL in breast cancer: A tangle of non‑coding threads (Review)

et al. 2020

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Breast cancer is a complex disease posing a serious threat to the female population worldwide. A complex molecular landscape and tumor heterogeneity render breast cancer cells resistant to drugs and able to promote metastasis and invasiveness. Despite the recent advancements in diagnostics and drug discovery, finding an effective cure for breast cancer is still a major challenge. Positive and negative regulation of apoptosis has been a subject of extensive study over the years. Numerous studies have shed light on the mechanisms that impede the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling cascade. Long non-coding RNAs (lncRNAs) have been implicated in the orchestration, development, proliferation, differentiation and metastasis of breast cancer. However, the roles of lncRNAs in fine-tuning apoptosis regulating machinery in breast cancer remain to be elucidated. The present review illuminates the roles of these molecules in the regulation of breast cancer and the interplay between lncRNA and TRAIL in breast cancer. The present review also attempts to reveal their role in the regulation of apoptosis in breast cancer appears a promising approach for the development of new diagnostic and therapeutic regimens.

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Long noncoding RNA Z38 promotes cell proliferation and metastasis and inhibits cell apoptosis in human gastric cancer

Cited by 3 publications

References 26 publications

Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma

Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma

LncRNA AC093818.1 accelerates gastric cancer metastasis by epigenetically promoting PDK1 expression

Long non‑coding RNA regulation of TRAIL in breast cancer: A tangle of non‑coding threads (Review)

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