Choroidal metastasis of gastric adenocarcinoma as a first sign of systemic disease recurrence: case report

Melo, Daniela Oliveira de; Filho, Paulo de Tarso Ponte Pierre; Gomes, Paulo Rogers Parente; Holanda, Andréa Gifoni Siebra de; Amadei, Larissa Pereira da Ponte

doi:10.1590/s0004-27492010000500017

Cited by 6 publications

(5 citation statements)

References 7 publications

(14 reference statements)

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“…12 Metastatic ocular tumours that originate from the gastrointestinal tract are rare. 4–8 In our current report we describe the diagnosis of choroidal metastasis originating from GC. Following eye removal surgery, the patient was relieved of pain and recovered well.…”

Section: Discussionmentioning

confidence: 89%

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Choroidal metastasis from gastric cancer: A case report and review of the literature

Huang,

Zhu,

2023

J Int Med Res

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Choroidal metastatic tumours from gastric cancer (GC) are rare compared with breast and lung cancer. Here, we report a patient with GC who presented to our ophthalmology clinic with a one-week history of left eye visual disorder and pain. Fundoscopic and B-scan examinations suggested a choroidal metastatic tumour. Computed tomography (CT) and magnetic resonance imaging (MRI) scans confirmed our initial diagnosis. Histopathology and immunohistochemical findings showed the tumour most likely originated from the gastrointestinal tract. Although the patient was well after eye removal, he died two months after surgery. Metastasis of GC should be a consideration when a patient with a history of GC presents with eye pain, decreased vision, and/or high intraocular pressure.

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Section: Discussionmentioning

confidence: 89%

“…2,3 However, choroidal metastases arising from gastric cancer (GC) are rare. [4][5][6][7][8] In a survey of 520 patients with GC, choroidal metastasis was found in only 4% patients. 4 Choroidal metastases tend to occur late in the course of cancer, and are associated with a poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

Choroidal metastasis from gastric cancer: A case report and review of the literature

Huang,

Zhu,

2023

J Int Med Res

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“…Although the patient received systemic chemotherapy with oxaliplatin, tegafur, and erbitux, choroidal metastasis in the patient progressed, inducing spontaneous rupture of the eyeball. While our enucleation procedure reduced the risk of orbital recurrence of the tumor, Melo et al [25] enucleated the affected eye when choroidal tumor from GC infiltrated the macular area and extended around the optic nerve head, orbital recurrence still occurred. Indeed, no orbital metastasis-related symptoms were reported by our patient during the 2-month postoperative follow-up.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous rupture of the eyeball due to choroidal metastasis of gastric carcinoma

Zhang

et al. 2019

Medicine

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Rationale:Although metastatic tumor is the most common intraocular malignancy, choroidal metastasis from gastric cancer is relatively rare. We present the exact course of a spontaneous rupture of the eyeball with choroidal metastasis from gastric carcinoma (GC) and the applied surgical interventions.Patient concerns:A 59-year-old male presented with pain and vision loss on his left eye for 6 months. He was diagnosed with GC, for which he received systemic chemotherapy for a year.Diagnoses:Preoperative B-scan, color fundus photography, computed tomography, and magnetic resonance imaging showed a choroidal tumor in his left eye. The spontaneous rupture of the corneoscleral limbus from 2 to 5 o’clock, combined secondary glaucoma, exudative retinal detachment and choroidal detachment were found.Interventions:The ruptured corneoscleral limbus was sutured and the orbit was lavaged with 0.4% cisplatin during the enucleation.Outcomes:Histopathology confirmed high homology of the choroidal metastasis and GC. He survived for 2 months after surgery, without pain or orbital neoplasms.Lessons:Choroidal metastasis from GC rapidly progressed to spontaneous rupture of the eyeball. Careful eyeball enucleation followed by orbital lavage with chemotherapeutics may reduce metastasis risk beyond the eyeball. Additional therapeutic interventions should be considered in patients resistant to single systemic chemotherapy.

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“…In our case, chemoradiation therapy (CRT) achieved complete remission and saved the patient from going blind as well. It is reported that choroidal metastasis from gastric adenocarcinoma is almost resistant to various therapies and is presented with multiple organ metastasis and severe prognosis [ 1 , 3 ]. It is interesting that multimodal therapy was effective in our case and local control for the metastatic ocular lesion was achieved.…”

Section: Case Presentationmentioning

confidence: 99%

Solitary choroidal metastasis from gastric adenocarcinoma: a case report

et al. 2017

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BackgroundMetastatic choroidal carcinomas that originated from the gastrointestinal tract are extremely rare. We report a case of suspected solitary choroidal metastasis from gastric adenocarcinoma.Case presentationThe patient was a 60-year-old man who had undergone laparoscopic distal gastrectomy with D1+ lymphadenecetomy for gastric cancer. The clinical stage was T1bN0M0 (TNM classification), but the pathological stage was T4aN0M0 beyond expectation. Adjuvant chemotherapy with oral Tegafur, Gimeracil, Oteracil potassium (TS-1®) was initiated. But he suddenly complained of decreased visual acuity in his right eye about 8 months later. This was suspected to be caused by choroidal metastasis of gastric adenocarcinoma. Chemotherapy with paclitaxel (PTX) and intensity-modulated radiotherapy (IMRT) achieved complete remission and spared the patient from going blind.ConclusionsThis case demonstrates that we should be aware of the possibility of choroidal metastases, when visual symptoms arise during treatment of gastric cancer.

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Choroidal metastasis of gastric adenocarcinoma as a first sign of systemic disease recurrence: case report

Cited by 6 publications

References 7 publications

Choroidal metastasis from gastric cancer: A case report and review of the literature

Choroidal metastasis from gastric cancer: A case report and review of the literature

Spontaneous rupture of the eyeball due to choroidal metastasis of gastric carcinoma

Solitary choroidal metastasis from gastric adenocarcinoma: a case report

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