Solitary choroidal metastasis from gastric adenocarcinoma: a case report

Shimada, Masanari; Amaya, Susumu; Shiba, Hiroaki; Furutani, Yuichiro; Munemoto, Yoshinori; Mitsui, Toshio; Tanahashi, Takao; Kikuchi, Yuzo

doi:10.1186/s40792-017-0311-5

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…The patients with choroidal metastasis have a poor prognosis. [26,27] The reported cases with choroidal metastasis from GC had survival durations of 9 months [16] and 3 years, [15] and our patient died 8 months after the first diagnosis of choroidal metastasis. Poor response to chemotherapy and long duration of choroidal metastasis from GC may have led to spontaneous rupture of the eyeball.…”

Section: Discussionmentioning

confidence: 84%

“…[1,9] However, systemic chemotherapy is commonly used for choroidal metastasis from GC as it is insensitive to radiotherapy. [3] A combination of systemic paclitaxel and local intensity-modulated radiotherapy provided remission in a case of choroidal metastasis from GC, [15] while chemotherapy with oral S-1 and intravenous cisplatin reduced choroidal lesions in another case. [7] However, choroidal metastasis from GC was found to be resistant to systemic imatinib.…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous rupture of the eyeball due to choroidal metastasis of gastric carcinoma

Zhang

et al. 2019

Medicine

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Rationale:Although metastatic tumor is the most common intraocular malignancy, choroidal metastasis from gastric cancer is relatively rare. We present the exact course of a spontaneous rupture of the eyeball with choroidal metastasis from gastric carcinoma (GC) and the applied surgical interventions.Patient concerns:A 59-year-old male presented with pain and vision loss on his left eye for 6 months. He was diagnosed with GC, for which he received systemic chemotherapy for a year.Diagnoses:Preoperative B-scan, color fundus photography, computed tomography, and magnetic resonance imaging showed a choroidal tumor in his left eye. The spontaneous rupture of the corneoscleral limbus from 2 to 5 o’clock, combined secondary glaucoma, exudative retinal detachment and choroidal detachment were found.Interventions:The ruptured corneoscleral limbus was sutured and the orbit was lavaged with 0.4% cisplatin during the enucleation.Outcomes:Histopathology confirmed high homology of the choroidal metastasis and GC. He survived for 2 months after surgery, without pain or orbital neoplasms.Lessons:Choroidal metastasis from GC rapidly progressed to spontaneous rupture of the eyeball. Careful eyeball enucleation followed by orbital lavage with chemotherapeutics may reduce metastasis risk beyond the eyeball. Additional therapeutic interventions should be considered in patients resistant to single systemic chemotherapy.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Spontaneous rupture of the eyeball due to choroidal metastasis of gastric carcinoma

Zhang

et al. 2019

Medicine

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“…From a review of published studies between 2011 and 2019, we identified only five other case reports of choroidal metastases from GC (Table 1). [13][14][15][16][17] Two reports were from Japan, and one each from China, Korea and Nepal. Four patients were male and one female and ages ranged from 40 to 75 years.…”

Section: Discussionmentioning

confidence: 99%

Choroidal metastasis from gastric cancer: A case report and review of the literature

Huang,

Zhu,

2023

J Int Med Res

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Choroidal metastatic tumours from gastric cancer (GC) are rare compared with breast and lung cancer. Here, we report a patient with GC who presented to our ophthalmology clinic with a one-week history of left eye visual disorder and pain. Fundoscopic and B-scan examinations suggested a choroidal metastatic tumour. Computed tomography (CT) and magnetic resonance imaging (MRI) scans confirmed our initial diagnosis. Histopathology and immunohistochemical findings showed the tumour most likely originated from the gastrointestinal tract. Although the patient was well after eye removal, he died two months after surgery. Metastasis of GC should be a consideration when a patient with a history of GC presents with eye pain, decreased vision, and/or high intraocular pressure.

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“…Intraocular malignancy is a rare disease and is most commonly caused bymetastatic tumors [3] . Choroidal metastatic tumors from malignancies in the gastrointestinal tract are extremely rare compared with the more common metastatic breast and pulmonary carcinomas [9] . Nevertheless, metastatic tumors in the orbit account for only 2-3% of all systemic cancers.…”

Section: Discussionmentioning

confidence: 99%

Choroidal metastasis from gastric carcinoma:a case report

Huang

Zhang

Geng

et al. 2020

Preprint

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BackgroundChoroidal metastasis in patients with gastric cancer is extremely rare. Furthermore, orbital and intraocular metastasis are generally associated with a bad prognosis. Here, we retrospectively report a patient with gastric carcinoma and choroidal metastasis.Case presentationA 59-year-old man with a history of gastric cancer was admitted to the Ophthalmology Department of our hospital due to a one-week history of eye pain; It was only eight months since the gastric cancer was diagnosed. The patient was diagnosed with gastric cancer at a local hospital two years previously, but had then spread to the left femur. The patient then received systemic chemotherapy at the local hospital. However, scans of his eyes in our hospital revealed a choroidal tumor in his left eye. The histopathological and immunohistochemical features of the removed eyeball suggested metastatic carcinoma, most likely originating in the gastrointestinal tract, and were consistent with a moderately well-differentiated gastric cancer.ConclusionsChoroidal metastasis can masquerade as glaucoma. Consequently, choroid metastasis of gastric cancer should be a consideration when a patient with a history of gastric cancer presents with eye pain, impaired vision, or high intraocular pressure.

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Solitary choroidal metastasis from gastric adenocarcinoma: a case report

Cited by 5 publications

References 13 publications

Spontaneous rupture of the eyeball due to choroidal metastasis of gastric carcinoma

Spontaneous rupture of the eyeball due to choroidal metastasis of gastric carcinoma

Choroidal metastasis from gastric cancer: A case report and review of the literature

Choroidal metastasis from gastric carcinoma:a case report

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