Spontaneous rupture of the eyeball due to choroidal metastasis of gastric carcinoma

Abstract

Rationale:Although metastatic tumor is the most common intraocular malignancy, choroidal metastasis from gastric cancer is relatively rare. We present the exact course of a spontaneous rupture of the eyeball with choroidal metastasis from gastric carcinoma (GC) and the applied surgical interventions.Patient concerns:A 59-year-old male presented with pain and vision loss on his left eye for 6 months. He was diagnosed with GC, for which he received systemic chemotherapy for a year.Diagnoses:Preoperative B-scan, color fundus photography, computed tomography, and magnetic resonance imaging showed a choroidal tumor in his left eye. The spontaneous rupture of the corneoscleral limbus from 2 to 5 o’clock, combined secondary glaucoma, exudative retinal detachment and choroidal detachment were found.Interventions:The ruptured corneoscleral limbus was sutured and the orbit was lavaged with 0.4% cisplatin during the enucleation.Outcomes:Histopathology confirmed high homology of the choroidal metastasis and GC. He survived for 2 months after surgery, without pain or orbital neoplasms.Lessons:Choroidal metastasis from GC rapidly progressed to spontaneous rupture of the eyeball. Careful eyeball enucleation followed by orbital lavage with chemotherapeutics may reduce metastasis risk beyond the eyeball. Additional therapeutic interventions should be considered in patients resistant to single systemic chemotherapy.

Choroidal metastasis from gastric cancer: A case report and review of the literature

“… 12 Metastatic ocular tumours that originate from the gastrointestinal tract are rare. 4 – 8 In our current report we describe the diagnosis of choroidal metastasis originating from GC. Following eye removal surgery, the patient was relieved of pain and recovered well.…”

“… 2 , 3 However, choroidal metastases arising from gastric cancer (GC) are rare. 4 – 8 In a survey of 520 patients with GC, choroidal metastasis was found in only 4% patients. 4 Choroidal metastases tend to occur late in the course of cancer, and are associated with a poor prognosis.…”

Risk factors for intraocular metastasis of primary liver cancer in diabetic patients: Alpha-fetoprotein and cancer antigen 125

“…To date, carcinoma-related IOM has been reported in patients with rectal cancer[ 14 ], lung cancer[ 15 ], breast cancer[ 16 ], esophageal carcinoma[ 17 ], thyroid cancer[ 18 ], gastric carcinoma[ 19 ], renal cancer[ 20 ], and choriocarcinoma[ 21 ] (Table 5 ).…”