Risk of late-onset hypogonadism (andropause) in Brazilian men over 50 years of age with osteoporosis: usefulness of screening questionnaires

Clapauch, Ruth; Braga, Daniel; Marinheiro, Lizanka Paola Figueiredo; Buksman, Salo; Schrank, Yolanda

doi:10.1590/s0004-27302008000900006

Cited by 28 publications

(19 citation statements)

References 33 publications

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“…Chi-squared test was used to compare frequencies of outcomes of interest between categorical variables, with a significant statistical level set at p < 0.05. (13). There was no difference in TT levels between osteoporotic (499 ± 15 ng/dL) and age and colour matched normal BMD men (538 ± 17 ng/dL, p = 0.0881).…”

Section: Methodsmentioning

confidence: 78%

Total estradiol, rather than testosterone levels, predicts osteoporosis in aging men

Clapauch¹,

Mattos²,

Silva³

et al. 2009

Arq Bras Endocrinol Metab

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Objective: To study and establish sex hormone cutoff levels for osteoporosis risk in men over 50 years old. Methods: Case-control study of 216 men > 50 years, 110 with osteoporosis (O) and 106 with normal bone density (C). We measured estradiol (E2), sex hormone binding globulin (SHBG), total testosterone (TT) and albumin. Free testosterone (FT) and bioavailable testosterone (BT) were calculated through Vermeulen's formula. Results: There was no difference in TT between groups. Relative risks of osteoporosis were 1.89 for E2 < 37 pg/mL (p = 0.02); 1.91 for SHBG > 55 nmol/L (p = 0.019); 2.5 for FT < 7 ng/dL (p = 0.015); 2.7 for BT < 180 ng/dL (p = 0.0003). Conclusions:In men over 50 years old, TT was not indicative of osteoporosis risk while E2 < 37 ng/mL was. SHBG > 55 nmol/L, FT < 7 ng/dL and BT < 180 ng/dL can represent additional indications for osteoporosis screening in men over 50 years old. Arq Bras Endocrinol Metab. 2009;53(8):1020-5 Keywords Male osteoporosis; estradiol; testosterone; free estradiol; free testosterone; SHBG resumo Objetivo: Estudar e estabelecer pontos de corte dos hormônios sexuais para risco de osteoporose em homens após os 50 anos de idade. Métodos: Estudo caso-controle de 216 homens > 50 anos, 110 com osteoporose e 106 com densidade óssea normal. Foram dosados: estradiol (E2), globulina ligadora de hormônios sexuais (SHBG), testosterona total (TT) e albumina. Foram calculadas: testosterona livre (TLC) e testosterona biodisponível (TB) pela fórmula de Vermeulen. Resultados: Não houve diferença na TT entre os grupos. Os riscos relativos de osteoporose foram de 1,89 para E2 < 37 pg/mL (p = 0,02); 1,91 para SHBG > 55 nmol/L (p = 0,019); 2,5 para TLC < 7 ng/dL (p = 0,015) e 2,7 para TB < 180 ng/dL (p = 0,0003). Conclusões: Em homens acima de 50 anos, TT não indicou risco de osteoporose, mas E2 < 37 pg/mL sim. SHBG > 55 nmol/L, TLC < 7 ng/dL e TB < 180 ng/dL podem representar indicações adicionais para pesquisa de osteoporose em homens acima de 50 anos. Arq Bras Endocrinol Metab. 2009;53(8):1020-5 Descritores

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Section: Methodsmentioning

confidence: 78%

Total estradiol, rather than testosterone levels, predicts osteoporosis in aging men

Clapauch¹,

Mattos²,

Silva³

et al. 2009

Arq Bras Endocrinol Metab

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“…Male or female hypogonadism may evolve, reduce mineral bone density and cause osteoporosis (58). This scenario may be aggravated by post-TBI immobility, as well as by the coexistence of other pituitary deficiencies.…”

Section: Morbidity In Brain and Head Injuries And Hormonal Replacementmentioning

confidence: 99%

Hypogonadism After Traumatic Brain Injury

Hohl¹,

Walz²

2017

Testosterone

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Traumatic brain injury (TBI) is the most common cause of death and disability in young adults. Post-TBI neuroendocrine disorders have been increasingly acknowledged in recent years due to their potential contribution to morbidity and, probably, to mortality after trauma. Marked alterations of the hypothalamic-pituitary axis during the post-TBI acute and chronic phases have been reported. Prospective and longitudinal studies have shown that some abnormalities are transitory. On the other hand, there is a high frequency (15% to 68%) of pituitary hormone deficiency among TBI survivors in a long term setting. Post-TBI hypogonadism is a common finding after cranial trauma, and it is predicted to develop in 16% of the survivors in the long term. Post-TBI hypogonadism has been associated with adverse results in the acute and chronic phases after injury. These data reinforce the need for identification of hormonal deficiencies and their proper treatment, in order to optimize patient recovery, improve their life quality, and avoid the negative consequences of non-treated hypogonadism in the long term. resumoO traumatismo cranioencefálico (TCE) é a causa mais comum de morte e incapacidade em adultos jovens. Desordens neuroendócrinas pós-TCE vêm sendo reconhecidas cada vez mais nos últimos anos devido à sua potencial contribuição para a morbidade e, possivelmente, mortalidade após trauma. Alterações acentuadas do eixo hipotálamo-hipófise foram documentadas nas fases aguda e crônica pós-TCE. Estudos prospectivos e longitudinais têm mostrado que algumas anormalidades são transitórias. Por outro lado, existe uma elevada frequência de deficiências hormonais hipofisárias a longo prazo entre os sobreviventes de TCE, que varia de 15% a 68%. Hipogonadismo pós-TCE é um achado comum a longo prazo e estima-se que, em média, 16% dos sobreviventes sejam afetados. Hipogonadismo pós-TCE tem sido associado a resultados adversos tanto na fase aguda quanto na fase crônica após a lesão. Esses dados reforçam a necessidade da identificação e adequado tratamento das deficiências hormonais, para otimizar a recuperação do paciente, melhorar a qualidade de vida e evitar as consequências negativas a longo prazo do hipogonadismo não tratado. Arq Bras Endocrinol Metab. 2009;53(8):908-14

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“…• Depression: hypogonadism in middle-age appears to be associated with a history of depressive symptoms; research suggests that hypogonadism may be an important factor in male depression 10 (A); • Decrease in muscle tissue, increase in muscular fibrous tissue and decrease in some aspects of muscular strength 11 (C); • Increase in total adipose tissue and redistribution of fat: various authors report an inverse correlation with testosterone, suggesting that the fall in testosterone levels has a causal role in the accumulation of visceral fat connected to male aging 12,13 (A); • Osteopenia and osteoporosis: decrease in bone mineral density 14,15 (B); • Decrease in testicular volume 16 …”

Section: (D)mentioning

confidence: 99%