Total estradiol, rather than testosterone levels, predicts osteoporosis in aging men

Clapauch, Ruth; Mattos, Tatiana Martins; Silva, Patrícia; Marinheiro, Lizanka Paola Figueiredo; Buksman, Salo; Schrank, Yolanda

doi:10.1590/s0004-27302009000800017

Cited by 10 publications

(5 citation statements)

References 44 publications

(43 reference statements)

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“…As we know, hormonal changes are vital factors for osteoporosis development especially in elderly women. There are controversial studies regarding the exact status of this important hormone in osteoporotic patients [56,57]. Nguyen et al showed that the serum levels of estradiol are important for bone mass development in both men and women [23].…”

Section: Discussionmentioning

confidence: 99%

Status of circulating bone turnover markers in elderly osteoporosis/osteopenia patients in comparison with healthy subjects

et al. 2020

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BackgroundIn the aging individuals, osteoporosis is a major health problem. Due to the various limitations of dual X-ray absorptiometry (DEXA) for diagnosis osteoporosis, serum-based biochemical markers have been suggested for the discrimination between the patients and healthy subjects.ObjectiveTo investigate the serum levels of bone turnover markers in elderly osteoporosis patients.MethodsThe serum samples from elderly subjects (osteoporosis (n = 28), osteopenia (n = 28), and healthy ones (n = 28) were collected from Amirkola Health and Ageing Project study. Furthermore, serum levels of bone formation and bone resorption markers as well as estrogen and progesterone were measured by enzyme-linked immunosorbent assay. Kruskal–Wallis test and receiver operating characteristic curve analysis were used for statistical analysis using SPSS.ResultsLevels of bone alkaline phosphatase (B-ALP) and procollagen type I N-terminal propeptide (PINP) differed between groups (P = 0.003 and 0.009, respectively). Furthermore, PINP and B-ALP levels had the best area under the curve, sensitivity, and specificity for the discrimination between patients with osteoporosis and healthy individuals.ConclusionIn conditions in which we are not able to assess the bone mineral density by DEXA, analysis of the B-ALP and PINP levels may be a helpful tool.

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Section: Discussionmentioning

confidence: 99%

Status of circulating bone turnover markers in elderly osteoporosis/osteopenia patients in comparison with healthy subjects

et al. 2020

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“…SHBG levels (detectable range: 0.2–180 nmol/L; inter-assay CV of 4.8%, and intra-assay CV of 3.5%) were determined using a DPC Immulite analyzer (Diamond Diagnostics, Holliston, MA). Free E2 was calculated based on mass action laws with Vermeulen's formula [38], [39].…”

Section: Methodsmentioning

confidence: 99%

The Impact of Estradiol and 1,25(OH)2D3 on Metabolic Syndrome in Middle-Aged Taiwanese Males

Cheng

Huang

et al. 2013

PLoS ONE

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In addition to adipocytokines, estradiol (E2) and vitamin D have been reported to affect insulin sensitivity, glucose homeostasis and body weight. However, studies about the impact of E2 and vitamin D on metabolic syndrome (MetS) are still limited. The aim of this study is to clarify the roles of circulating E2 and vitamin D on the risk of MetS in middle-aged Taiwanese males. A total of 655 male volunteers, including 243 subjects with MetS (mean age: 56.7±5.8 years) and 412 normal controls (mean age: 55.1±3.6 years), were evaluated. Subjects with MetS had significantly lower circulating E2, 1,25(OH)2D3, and adiponectin, and higher leptin than those without MetS (P<0.001 for all comparisons). E2 and 1,25(OH)2D3 were significantly associated with 4 individual components of MetS; more than adiponectin and leptin that were only associated with 3 individual components. In multivariate regression analysis, E2 (beta = −0.216, P<0.001) and 1,25(OH)2D3 (beta = 0.067, P = 0.045) were still significant predictors of MetS independent of adiponectin and leptin. Further large studies are needed to confirm our preliminary results and elucidate the possible mechanism.

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“…Hypogonadism with low testosterone levels is common in men with osteoporosis and fragility fractures [21]. An 8 am testosterone level and percentage of free testosterone measurement are often added to the osteoporosis workup panel for men.…”

Section: Diagnosis and Treatment Of Diseases Associated With Impairedmentioning

confidence: 99%

Short-term and Long-term Orthopaedic Issues in Patients With Fragility Fractures

Bukata

Kates

O’Keefe

2011

Clinical Orthopaedics &Amp; Related Research

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Background Patients with impaired bone quality who suffer a fragility fracture face substantial challenges in both their short-and long-term care. In addition to poor bone quality, many of these patients have multiple medical comorbidities that alter their surgical risk and affect their ultimate functional recovery. Some medical issues can contribute to the altered bone quality and must be addressed to prevent future fractures. Questions/purposes This review summarizes the modifications in perioperative management and fracture fixation in patients with common fragility fractures who have impaired bone quality. It also summarizes the postoperative diagnosis and treatment of secondary causes of impaired bone quality in these patients. Methods We performed a PubMed search, and literature published after 2000 was prioritized, with the exception of benchmark clinical trial studies published before 2000. Results Patients with altered bone quality require rapid perioperative management of multiple medical comorbidities. Implant selection in patients with poor quality bone should permit early weightbearing, and constructs should maximize surface area contact with the remaining bone. Long-term diagnosis and treatment of other disease states contributing to poor bone quality (vitamin D deficiency/ insufficiency, hypothyroidism, hyperthyroidism, hyperparathyroidism, Cushing's disease, and hypogonadism) must occur to minimize the chances of future fractures. Conclusions Recognition of patients with impaired bone quality and proper treatment of their special needs in both the short and long term are essential for their best opportunity for maximal functional recovery and prevention of future fractures.

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Total estradiol, rather than testosterone levels, predicts osteoporosis in aging men

Cited by 10 publications

References 44 publications

Status of circulating bone turnover markers in elderly osteoporosis/osteopenia patients in comparison with healthy subjects

Status of circulating bone turnover markers in elderly osteoporosis/osteopenia patients in comparison with healthy subjects

The Impact of Estradiol and 1,25(OH)2D3 on Metabolic Syndrome in Middle-Aged Taiwanese Males

Short-term and Long-term Orthopaedic Issues in Patients With Fragility Fractures

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