Disfunção endotelial no diabetes melito tipo 1

Bertoluci, Marcello Casaccia; Cé, Gislaine Vissoky; Silva, Antônio Marcos Vargas da; Puñales, Márcia Khaled

doi:10.1590/s0004-27302008000200030

Cited by 9 publications

(5 citation statements)

References 78 publications

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“…The levels of • NO are important markers of nitrooxidative stress and reduced bioavailability of • NO contributes to the pathogenesis of DM complications [9, 13, 29, 30]. Reported increased [31–33], decreased [18, 34] or not changed [35, 36] serum and plasma total • NO levels in T2DM subjects compared to healthy subjects have been described.…”

Section: Discussionmentioning

confidence: 99%

Altered superoxide dismutase-1 activity and intercellular adhesion molecule 1 (ICAM-1) levels in patients with type 2 diabetes mellitus

et al. 2019

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Inflammation and oxidative stress are linked to type 2 diabetes mellitus (T2DM). In this work, we analyzed patients’ blood markers of antioxidant capacity, oxidative stress and inflammation in individuals with T2DM, in pre-diabetes state (pre-DM) and controls without diabetes. Patients were divided into three groups, according to glycated hemoglobin A1c (HbA1c): <7%, 7–9%, and >9%. Superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities, total thiols, nitric oxide ( • NO), tumor necrosis factor alpha (TNF-α) and intercellular adhesion molecule 1 (ICAM-1) levels of the individuals were measured. Plasma SOD activity was higher in T2DM subjects compared to the controls. While total thiols levels were lower in T2DM groups when compared to pre-DM, the values remained unchanged when compared to controls. ICAM-1 levels of T2DM groups were lower than in controls, while GPx activity, • NO, and TNF-α levels were similar among all groups. A positive correlation was found between SOD and HbA1c levels. Concluding, individuals with T2DM present altered SOD activity, total thiols, and ICAM-1 levels, which might contribute to further complications. There is a positive correlation between SOD activity and HbA1c levels. No apparent correlation exists between total thiols and ICAM-1 levels and with any other of the parameters evaluated in this study.

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Section: Discussionmentioning

confidence: 99%

Altered superoxide dismutase-1 activity and intercellular adhesion molecule 1 (ICAM-1) levels in patients with type 2 diabetes mellitus

et al. 2019

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“…Endothelial remodeling and consequent detection of carotid intima-media layer thickening in patients with diabetes are associated with longer disease duration, poor glycemic and lipid control, and high blood pressure [23, 27, 28]. …”

Section: Discussionmentioning

confidence: 99%

Increased carotid intima-media thickness in Brazilian adolescents with type 1 diabetes mellitus

Fusaro

Zanini

Silva

2016

Diabetol Metab Syndr

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BackgroundIncreased carotid intima-media thickness (CIMT), a marker of subclinical atherosclerosis, is an independent predictor of future cardiovascular events, and has been reported in children with various chronic diseases, including type 1 diabetes mellitus (DM1).ObjectivesEvaluate CIMT and its association with cardiovascular risk factors in Brazilian adolescents with DM1.MethodsCross-sectional study of 118 adolescents, 57 with DM1 and no chronic complications related to the disease, and 61 healthy individuals. Clinical, biochemical, and high-resolution B-mode ultrasonographic evaluations according to the Consensus Statement of the American Society of Echocardiography CIMT Task Force were performed.ResultsAdolescents with diabetes (66.6% female) were 14.5 ± 2.9 years old and had 9.0 ± 4.0 years of disease duration. The healthy adolescents (62.3% female) were 14.3 ± 2.6 years old. All the adolescents had blood pressure within their reference ranges. In 66% of DM1 adolescents the systolic blood pressure was >50th percentile. Increased CIMT was observed in adolescents with diabetes compared with those in the control group: 0.53 vs 0.51 mm (p < 0.004) on the right side, and 0.55 vs 0.51 mm (p < 0.001) on the left side. CIMT presented independent and positive associations with diabetes duration, total cholesterol level, low-density lipoprotein cholesterol level, and systolic blood pressure percentile in DM1 adolescents.ConclusionsIncreased CIMT was observed in young Brazilian adolescents with DM1, and was associated with cardiovascular risk factors. CIMT assessment may be useful for the early identification and monitoring of cardiovascular risk in this age group.

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“…Type 1 diabetes patients are continuously exposed to a hyperglycemic environment and other CVD risk factors, such as insulin dosage and the presence of chronic complications [16]. All of these risk factors are present at a very young age, resulting in progressive endothelial dysfunction that results in the atherosclerosis process [12,14,15].…”

Section: Introductionmentioning

confidence: 99%

“…Even in type 1 diabetes patients without chronic complications there is a mild chronic inflammatory state, which can be observed as an elevation of acute phase proteins (such as C-reactive protein (CRP)) that may also contribute to atherosclerosis [18]. Furthermore, some other unknown CVD risk factors might be present as there is still a residual CVD risk even in patients with excellent metabolic control [16]. …”

Section: Introductionmentioning

confidence: 99%

Influence of a family history of type 2 diabetes, demographic and clinical data on carotid intima-media thickness in patients with type 1 diabetes: a cross-sectional study

Andrade

Silva

Matta

et al. 2014

Cardiovasc Diabetol

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BackgroundIntima-media thickness (IMT) of the common carotid artery is a surrogate end point of cardiovascular disease (CVD). Identifying the factors associated with a higher IMT may contribute to the identification of subjects with higher CVD risk. Our objective was to compare the common carotid IMT of type 1 diabetes patients to healthy control subjects. The secondary objective was to determine factors associated with a higher carotid IMT.MethodsWe conducted a cross-sectional study between March 2009 and October 2013, comprising 127 type 1 diabetes patients and 125 control subjects matched by age, gender and body mass index (BMI). Carotid IMT was measured using semi-automated edge detection software.ResultsType 1 diabetes patients had a higher median IMT compared with control subjects (0.538; IQR: 0.500-0.607 vs 0.513 mm; IQR: 0.481-0.557, respectively p = 0.001). Women with type 1 diabetes had a higher median IMT difference compared to the control group (0.537; IQR: 0.495-0.596 vs 0.502 mm; IQR: 0.472-0.543, respectively p = 0.003) than did men with type 1 diabetes (0.547; IQR: 0.504-0.613 vs 0.528 mm; IQR: 0.492-0.575, respectively p = 0.2). Age and diabetes duration had an additive effect on the IMT of type 1 diabetes patients. Multivariate gamma regression model analysis showed that in type 1 diabetes patients, the IMT was associated with age (Exp (β) = 1.006, p < 0.001), duration of diabetes (Exp (β) = 1.004, p = 0.001), BMI (Exp (β) = 1.005, p = 0.021), family history of type 2 diabetes (Exp (β) = 1.044, p = 0.033), total cholesterol (Exp (β) = 0.999, p = 0.001) and creatinine clearance (Exp (β) = 1.000, p = 0.043).ConclusionsPatients with type 1 diabetes have increased IMT, a marker of subclinical atherosclerosis. The CVD risk may be similar between men and women with type 1 diabetes, suggesting a loss of gender protection. Also, CVD risk may be higher in those with a family history of type 2 diabetes. Prospective studies are needed to confirm the predictive value of these findings and the causal effect between IMT and CVD in patients with type 1 diabetes.

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Disfunção endotelial no diabetes melito tipo 1

Cited by 9 publications

References 78 publications

Altered superoxide dismutase-1 activity and intercellular adhesion molecule 1 (ICAM-1) levels in patients with type 2 diabetes mellitus

Altered superoxide dismutase-1 activity and intercellular adhesion molecule 1 (ICAM-1) levels in patients with type 2 diabetes mellitus

Increased carotid intima-media thickness in Brazilian adolescents with type 1 diabetes mellitus

Influence of a family history of type 2 diabetes, demographic and clinical data on carotid intima-media thickness in patients with type 1 diabetes: a cross-sectional study

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