High-sensitivity C-reactive protein in subjects with type 2 diabetes mellitus and/or high blood pressure

Lima, Luciana Moreira; Carvalho, Maria das Graças; Soares, Anna L.; Sabino, Adriano de Paula; Fernandes, Ana Paula; Novelli, Bethânia A.; Sousa, Marinez O.

doi:10.1590/s0004-27302007000600010

Cited by 33 publications

(27 citation statements)

References 14 publications

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“…[3][4][5][6][7][8][9][10][11] So there was assumption that hypertensive individuals should have higher CRP. Like other studies 10,[14][15][16] we also got the same findings: Hypertensive subjects have higher CRP than those of normotensive subjects. There are many studies carried out to find the correlation whether higher level of CRP may lead to hypertensive complications, but it still remains controversial.…”

Section: Discussionsupporting

confidence: 88%

C-Reactive protein in hypertension as a cardiovascular risk factor: A prospective observational study

Alam

Rahman

Hoque

et al. 2018

Bangladesh Crit Care J

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Background and objective : C-reactive protein (CRP) is a well-known inflammatory biomarker and is associated with cardiovascular risk. Our objective was to see whether it is also associated with hypertension and its complications.Methodology : This prospective observational study was carried out in general outpatient department (OPD) of a tertiary level hospital on a total of 112 patients, among them 71 were hypertensive and 41 were normotensive. Baseline CRP was measured in all subjects and followed them up to six months to see any association between the level of CRP and hypertensive complications.Results : It is found that mean CRP was 2.923 (± 0.294) in hypertensive subjects and 1.058 (± 0.330) in normotensive subjects. No association is found between level of CRP and hypertensive complications.Conclusion : CRP is raised in hypertension. But it is not established that its level can predict the complication of hypertension.Bangladesh Crit Care J March 2018; 6(1): 3-6

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Section: Discussionsupporting

confidence: 88%

C-Reactive protein in hypertension as a cardiovascular risk factor: A prospective observational study

Alam

Rahman

Hoque

et al. 2018

Bangladesh Crit Care J

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“…The difference might be due to the different inflammatory conditions involved, since acute myocardial infarction causes acute inflammation and oxidative stress, whereas type 2 diabetes is a chronic inflammatory disorder [2, 30]. Although the serum levels of CRP, commonly used as a marker of inflammation, were not significantly increased in the T2D groups, it should be noted that an increase in CRP is not a universal feature of T2D [32, 33]. This suggests that inflammation may not be the major factor leading to the T2D observed, at least in this particular set of subjects.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Blood Activin Levels and Clinical Parameters of Type 2 Diabetes

Chen

et al. 2012

Experimental Diabetes Research

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Aims. Activins A and B, and their binding protein, follistatin, regulate glucose metabolism and inflammation. Consequently, their role in type 2 diabetes (T2D) was examined. Methods. Blood was taken from fasted participants (34 males; 58 females; 50–75 years) with diabetes or during an oral glucose tolerance test (OGTT). Clinical parameters were assessed, and blood assayed for activins, follistatin, and C-reactive protein. Results. Serum levels of activin A (93.3 ± 27.0 pg/mL, mean ± SD), B (81.8 ± 30.8 pg/mL), or follistatin (6.52 ± 3.15 ng/mL) were not different (P > 0.05) between subjects with normal OGTT (n = 39), impaired glucose tolerance and/or fasting glucose (n = 17), or T2D (n = 36). However, activin A and/or activin B were positively correlated with parameters of insulin resistance and T2D, including fasting glucose (P < 0.001), fasting insulin (P = 0.02), glycated hemoglobin (P = 0.003), and homeostasis model assessment of insulin resistance (HOMA-IR; P < 0.001). Follistatin was positively correlated with HOMA-IR alone (P = 0.01). Conclusions. These data indicate that serum measurements of activin A, B, or follistatin cannot discriminate risk for T2D in individual patients, but the activins display a positive relationship with clinical parameters of the disease.

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“…Saito et al [41] suggested that variations in circulating hsCRP, even within the normal range is involved in the interrelation of cardiovascular risk factors, like age, smoking, obesity, high blood pressure and dyslipidemia, which are supposed to promote atherosclerosis and ultimately provoke cardiovascular diseases, such as coronary artery disease. Lima et al [42] observed that patients who suffered from both hypertension and diabetes had higher levels of hsCRP than normal subjects; indicating that patients with two associated diseases have a more active inflammatory state.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Endothelial Dysfunction in Health and Disease; Using Various Parameters

Jalali

Phadke

2011

Ind J Clin Biochem

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Conditions like hypertension, atherosclerosis and diabetes are known to be the result of endothelial dysfunction which could begin early in the life of an individual. The markers of endothelial dysfunction studied in the present work are plasma hemoglobin, serum high sensitivity C-reactive protein (hsCRP) and plasma nitrite and nitrate. We studied the onset of endothelial dysfunction with increase in age as well as in disease condition like newly detected hypertensives and of hypertensive diabetic patients. The mean plasma hemoglobin and hsCRP values were found to increase with age. hsCRP and plasma hemoglobin levels were significantly higher in patient groups as compared to aged-matched controls. On the other hand nitrate and nitrite was significantly higher in patients who suffered from both diabetes and hypertension together and nitrate values were significantly lower in patients who suffered from hypertensive alone. Plasma hemoglobin and hsCRP are associated with endothelial dysfunction and increases both with age as well as in disease condition.

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High-sensitivity C-reactive protein in subjects with type 2 diabetes mellitus and/or high blood pressure

Cited by 33 publications

References 14 publications

C-Reactive protein in hypertension as a cardiovascular risk factor: A prospective observational study

C-Reactive protein in hypertension as a cardiovascular risk factor: A prospective observational study

Correlation between Blood Activin Levels and Clinical Parameters of Type 2 Diabetes

Assessment of Endothelial Dysfunction in Health and Disease; Using Various Parameters

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