C-Reactive protein in hypertension as a cardiovascular risk factor: A prospective observational study

Alam, Zahid; Rahman, Arifur; Hoque, Shabnam Jahan; Hossain, MZ; Ara, Rowsan; Safdar, Amb; Irfan, SM Rezaul; Khan, MM Zahurul Alam; Mohibullah, Akm

doi:10.3329/bccj.v6i1.36602

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…The current study also found that median values of CRP were significantly elevated in cases compared to controls (P <.001). These results concur with results from previous studies [31][32]. However, another older study by Sesso and others reported that CRP was not associated with higher risk of developing hypertension in middle-aged and older men [33].…”

Section: Discussionsupporting

confidence: 92%

Selected haematological markers and C-reactive protein, not AGTR1 SNP, are associated with essential hypertension in Tharaka Nithi County, Kenya

Mbaabu,

Mangare,

Wangulu

et al. 2023

AJMAH

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Background: Essential Hypertension (EH) accounts for majority of hypertension cases globally. Genetic factors along with haematological and biochemical changes may underlie EH and these have not been well studied in Kenya. A meta-analysis in African populations (excluding East Africa) identified the 1166A>C (rs5186) single nucleotide polymorphism (SNP) in the angiotensin II type 1 receptor gene (AGTR1) that encodes the angiotensin II type 1 receptor as likely to predispose some Africans to hypertension. Aim: The purpose of the study was to determine whether the AGTR1 (rs5186) mutation, C-reactive protein (CRP) and selected haematological biomarkers may be associated with the onset of EH in Tharaka Nithi County, Kenya). Study Design: A case control study design was adopted. Place and Duration of Study: The research was conducted from March to July 2022 at Chuka County Referral Hospital in Tharaka Nithi County. Methodology: A total of 272 participants, both hypertensive and normotensive, were recruited and blood samples obtained. DNA was extracted and analyzed by PCR RFLP. Independent T-test, Mann Whitney U test and Odds ratios were used to compare the two groups. P values less than 0.05 were considered statistically significant. Results: Median values for Red Cell Distribution Width (RDW), C-reactive Protein (CRP) and mean values for Mean Platelet Volume (MPV) and Neutrophil to Lymphocyte ratio (NLR) were significantly higher (P < .001) in hypertensive group compared to normotensive individuals. Mean Platelet Distribution Width (PDW) was not significantly different between cases and controls. (P=.519) There was no significant association between the AGTR1 1166A>C (rs5186) SNP frequency and EH in both groups (P=0.6236, OR=0.4952(95%CI:0.0442-5.5456) Conclusion: The AGTR1 (rs5186) SNP is not associated with EH in Tharaka Nithi County, Kenya. EH is associated with elevated levels of CRP, RDW, MPV and NLR in the absence of other inflammatory and chronic diseases. Further studies of the genetics of hypertension in Kenya need to be conducted.

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Section: Discussionsupporting

confidence: 92%

Selected haematological markers and C-reactive protein, not AGTR1 SNP, are associated with essential hypertension in Tharaka Nithi County, Kenya

Mbaabu,

Mangare,

Wangulu

et al. 2023

AJMAH

View full text Add to dashboard Cite

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“…Ethnic group differences were evident in detecting the association of CRP levels with hypertension [71]. No correlation was found between CRP and hypertension levels in Bangladeshi [72], and Chinese participants, except Hispanic participants [73]. A study showed that an increased CRP level would not result in a higher CKD risk [74].…”

Section: Plos Onementioning

confidence: 99%

Hematological abnormalities and comorbidities are associated with COVID-19 severity among hospitalized patients: Experience from Bangladesh

et al. 2021

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Background The hematological abnormalities are assumed to be involved in the disease progression of COVID-19. However, the actual associations between specific blood parameters and COVID-19 are not well understood. Here we aimed to assess the correlations between hematological parameters and the severity of COVID-19. Methods We included COVID-19 patients who were admitted to Evercare Hospital Ltd, Dhaka, Bangladesh, between November 10, 2020, to April 12, 2021, with a confirmed case of RT-PCR test. We recorded demographic information, clinical data, and routine hematological examination results of all COVID-19 patients. We performed statistical analyses and interpretation of data to compare severe COVID-19 patients (SCP) and non-severe COVID-19 patients (NSCP). Results The age and BMI of the admitted COVID-19 patients were 48.79±8.53 years and 25.82±3.75 kg/m2. This study included a total of 306 hospitalized COVID-19 patients. Among them, NSCP and SCP were 198 and 108, respectively. And we recorded 12 deaths from SCP. We observed the alterations of several hematological parameters between SCP and NSCP. Among them, we noticed the increased levels of C-reactive protein (CRP), d-dimer, and ferritin showed good indicative value to evaluate the severity of COVID-19. Also, there were positive correlations among these parameters. Moreover, we found correlations between the outcomes of COVID-19 patients with patient’s demographics and comorbid diseases. Conclusion Based on our results, CRP, d-dimer, and ferritin levels at admission to hospitals represent simple assessment factors for COVID-19 severity and the treatment decisions at the hospital setup. These blood parameters could serve as indicators for the prognosis and severity of COVID-19. Therefore, our study findings might help to develop a treatment protocol for COVID-19 patients at the hospital setup.

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C-Reactive protein in hypertension as a cardiovascular risk factor: A prospective observational study

Cited by 2 publications

References 13 publications

Selected haematological markers and C-reactive protein, not AGTR1 SNP, are associated with essential hypertension in Tharaka Nithi County, Kenya

Selected haematological markers and C-reactive protein, not AGTR1 SNP, are associated with essential hypertension in Tharaka Nithi County, Kenya

Hematological abnormalities and comorbidities are associated with COVID-19 severity among hospitalized patients: Experience from Bangladesh

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