A administração de nandrolona não promove hipertrofia do músculo sóleo em ratos

Abstract

RESUMOOs esteróides anabólicos androgênicos (EAA) são compostos formados a partir da testosterona ou um de seus derivados, sendo amplamente utilizados por desportistas amadores e profissionais com o objetivo de melhorar a performance atlética. Entretanto, a literatura a respeito da relação entre EAA e hipertrofia muscular é controversa. O objetivo deste estudo foi avaliar os efeitos da nandrolona e do treinamento físico sobre a hipertrofia muscular. Ratos Wistar machos receberam injeção i.m. de DecaDurabolin® ou veículo durante 6 semanas. Os animais dos grupos treinados foram submetidos a treinamento físico resistido, através de sessões de saltos em meio líquido. Os animais sedentários e treinados foram sacrificados após anestesia e o músculo sóleo retirado para quantificação de proteínas totais e DNA. Ao final do tratamento, os animais treinados tratados com veículo ou EAA apresentaram menor peso corporal do que os respectivos grupos sedentários. Não foram observadas diferenças estatísticas na concentração de proteínas totais e na razão peso muscular/peso corporal entre os grupos experimentais. O grupo treinado tratado com EAA apresentou concentração de DNA significativamente menor do que o grupo treinado veículo. A administração de decanoato de nandrolona não promoveu hipertrofia do músculo sóleo, nem mesmo quando associada ao treinamento físico resistido. ABSTRACT Nandrolone Administration Does Not Promote Hypertrophy of Soleus Muscle in Rats.Anabolic androgenic steroids (AAS) are compounds formed from testosterone or one of its derivatives, which are largely used by amateur e professional athletes to improve the athletic performance. However, the scientific information about the relation between the use of AAS and muscle hypertrophy is controversial. The aim of this study was to evaluate the effects of testosterone and physical training on muscle hypertrophy. Male Wistar rats received i.m. injections of Deca-Durabolin ® or vehicle during 6 weeks. Trained rats were submitted to a resistance physical training, by jumping up and down in water carrying an overload. Sedentary and trained animals were anesthetized and sacrificed. Soleus muscle was removed for the quantification of total protein and DNA concentration. In the end of the treatment, body weight of trained animals treated with vehicle or AAS was lower than the body weight of respective sedentary. Total protein concentration and the ratio muscle weight/body weight of all experimental groups were not altered. Trained group treated with AAS presented lower DNA concentration than trained group treated with vehicle. The administration of nandrolone decanoate did not promote hypertrophy on soleus muscle, not even when the use of AAS was associated to resistance physical training.

Morphofunctional characteristics of skeletal muscle in rats with cerebral palsy

“…In scientific research using rats, one of the muscles most investigated is the plantaris muscle . It is part of the group of plantar flexors muscles, together with the soleus and gastrocnemius muscles . It consists predominantly of type II fibres, having a glycolytic characteristic .…”

Perfil eletrocardiográfico e conteúdo glicogênico muscular de ratos tratados com nandrolona

“…widely used in the world 6 . It is available commercially as an injectable anabolic preparation and its action lasts for up to three weeks, after intramuscular administration in humans 7 .…”

“…This study was based on the assessment of the effects of nandrolone at a dose of 5 mg/kg/week, which is equivalent to the dose mentioned in the literature. This dose is regarded as excessive and it is usually administered to athletes at the beginning of sports practice 6 . In the proposal presented herein, the evaluation was directed at the electrocardiographic profile, glycogen content total-protein content of skeletal muscles and heart muscles, as well as plasma albumin concentrations.…”

Anabolic Steroids Effects on Bone Regeneration

“…From 1976, at Montreal Olympics, control of AAS began, where six athletes were punished for use of these substances [4]. This control occurred for ethical reasons and because of harmful effects on health.…”